Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment

2019 ◽  
Vol 42 (6) ◽  
pp. 815-828 ◽  
Author(s):  
Ada Koschorke ◽  
Simona Faraci ◽  
Debora Giani ◽  
Claudia Chiodoni ◽  
Egidio Iorio ◽  
...  
Keyword(s):  
Stem Cell ◽  
Ovarian Carcinoma ◽  
Phenethyl Isothiocyanate ◽  
Her2 Positive ◽  
Cell Compartment ◽  
Stem Cell Compartment

scholarly journals Donor-intrinsic variables determine mobilization efficiency: analyses from a cohort of sixty twice-mobilized stem cell donors

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Soo-Zin Kim-Wanner ◽  
Seo-Youn Lee ◽  
Erhard Seifried ◽  
Halvard Bonig
Keyword(s):  
Stem Cell ◽  
Time Lag ◽  
Graft Function ◽  
Anecdotal Evidence ◽  
Cell Compartment ◽  
Small Minority ◽  
Stem Cell Compartment ◽  
Poor Graft Function ◽  
Genetically Determined ◽  
First Time

Abstract Background Healthy volunteer registry donors have become the backbone of stem cell transplantation programs. While most registrants will never become actual donors, a small minority are called upon twice, most commonly for the same patient because of poor graft function. Anecdotal evidence provides no hard reasons to disallow second-time mobilized apheresis, but few centers have treated enough two-time donors for definitive conclusions. Moreover, for reasons unknown, the efficiency of G-CSF varies greatly between donations. Methods Comparison of outcomes of first vs. second donations can formally confirm G-CSF responsiveness as intrinsically, likely genetically, determined. In our database, we identified 60 donors (1.3%) who received two cycles of G-CSF 24 days to 4 years apart and systematically compared mobilization outcomes. Results First and second mobilization and collection proceeded without severe or unusual adverse effects. First-time mobilization efficiency was highly predictive of second-time mobilization. Neither mobilization efficiency nor time lag between donations affected the similarity of first- and second-time mobilization outcomes. Conclusions With the caveat that only donors with an unremarkable first donation were cleared for a second, our data indicate that a second donation is feasible, equally tolerable as a first donation, and efficient. Moreover, the data strongly support the notion of donor-intrinsic variables dictating mobilization response and argue against relevant damage to the stem cell compartment during mobilization with rhG-CSF.

The role of FGF signaling pathway in the pituitary stem cell compartment

2021 ◽  
Author(s):  
Sherwell Sanchez Carlos M. Abascal ◽  
Emily Lodge ◽  
Thea L. Willis ◽  
Mohammad K. Hajihosseini ◽  
Cynthia L. Andoniadou
Keyword(s):  
Stem Cell ◽  
Signaling Pathway ◽  
Fgf Signaling ◽  
Cell Compartment ◽  
Stem Cell Compartment

scholarly journals Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

2007 ◽  
Vol 104 (10) ◽  
pp. 4048-4053 ◽  
Author(s):  
C. D. Peacock ◽  
Q. Wang ◽  
G. S. Gesell ◽  
I. M. Corcoran-Schwartz ◽  
E. Jones ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Stem Cell ◽  
Hedgehog Signaling ◽  
Tumor Stem Cell ◽  
Cell Compartment ◽  
Stem Cell Compartment
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