Etiology of familial breast cancer with undetected BRCA1 and BRCA2 mutations: clinical implications

2013 ◽  
Vol 37 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Eugenia Yiannakopoulou
Keyword(s):  
Breast Cancer ◽  
Familial Breast Cancer ◽  
Clinical Implications ◽  
Brca1 And Brca2 ◽  
Brca2 Mutations ◽  
Brca1 And Brca2 Mutations

Familial breast cancer: double heterozygosity for BRCA1 and BRCA2 mutations with differing phenotypes

2007 ◽  
Vol 7 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Margaret Smith ◽  
Susan Fawcett ◽  
Emanouil Sigalas ◽  
Richard Bell ◽  
Sophie Devery ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Familial Breast Cancer ◽  
Brca1 And Brca2 ◽  
Brca2 Mutations ◽  
Double Heterozygosity ◽  
Brca1 And Brca2 Mutations

scholarly journals BRCA1 and BRCA2 mutations in Russian familial breast cancer

2002 ◽  
Vol 19 (2) ◽  
pp. 184-184 ◽  
Author(s):  
Irina V. Tereschenko ◽  
Victoria M. Basham ◽  
Bruce A.J. Ponder ◽  
Paul D.P. Pharoah
Keyword(s):  
Breast Cancer ◽  
Familial Breast Cancer ◽  
Brca1 And Brca2 ◽  
Brca2 Mutations ◽  
Brca1 And Brca2 Mutations

scholarly journals Prevalance of BRCA1 and BRCA2 mutations in familial breast cancer patients in Lebanon

2012 ◽  
Vol 10 (1) ◽  
Author(s):  
Nadine Jalkh ◽  
Jinane Nassar-Slaba ◽  
Eliane Chouery ◽  
Nabiha Salem ◽  
Nancy Uhrchammer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Familial Breast Cancer ◽  
Breast Cancer Patients ◽  
Brca1 And Brca2 ◽  
Brca2 Mutations ◽  
Brca1 And Brca2 Mutations

scholarly journals A MOLECULAR-BASED APPROACH TO INVESTIGATE BREAST CANCER 1 AND BREAST CANCER 2 STATUS IN OVARIAN CANCER AMONG IRAQI WOMEN

2018 ◽  
Vol 11 (7) ◽  
pp. 199
Author(s):  
Muhannad Shweash ◽  
Saddam Jumaa Naseer ◽  
Maisam Khider Al-anii ◽  
Thulfiqar Fawwaz Mutar
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Cancer Patients ◽  
Gene Mutations ◽  
Healthy Controls ◽  
Brca1 And Brca2 ◽  
First Degree Relatives ◽  
Brca Gene ◽  
Brca2 Mutations ◽  
Brca1 And Brca2 Mutations

Objective: Cancer ovary is one of the fatal gynecologic malignancies worldwide. Since breast cancer (BRCA) genes are considered tumor suppressor genes and play important roles in cancer by repairing of chromosomal damage with the error repair of DNA breaks. Therefore, breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) gene mutations strongly enhance the development of ovarian cancer risk among women. Here, we report that both genes are an essential mediator of progress ovarian cancer, to determine the influence of BRCA1 and BRCA2 mutations in the improvement of ovarian cancer.Methods: A total of 25 subjects were chosen for the genetic studies, and three groups were recruited: fifteen ovarian cancer patients group, five healthy controls, and five first-degree relatives to a known case of ovarian cancer patients.Results: A genetic analysis revealed that a strong correlation exists between both gene mutations’ status in ovarian cancer, and BRCA gene mutations (185delAG, 5382insC, and 4153delA in BRCA1 and 6174delT in BRCA2) remained to establish to have a relatively high frequency among people in this study among ovarian cancer patients. Furthermore, seven patients with ovarian cancer carried all of the four investigated mutations, and five had three mutations.Conclusion: Otherwise, BRCA gene frequency showed low prevalence among first-degree relatives, and to a lesser extent among healthy controls, with only a few had all of the mutations combined. These data demonstrate for the first time a molecular link between BRCA1 and BRCA2 mutations in ovarian cancer progression in Iraq.

Clinical implications of genetic testing for BRCA1 and BRCA2 mutations in Austria

2013 ◽  
Vol 85 (1) ◽  
pp. 72-75 ◽  
Author(s):  
CF Singer ◽  
D Muhr ◽  
C Rappaport ◽  
M-K Tea ◽  
D Gschwantler-Kaulich ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Clinical Implications ◽  
Brca1 And Brca2 ◽  
Brca2 Mutations ◽  
Brca1 And Brca2 Mutations

Abstract 2512: BRCA1 and BRCA2 mutations and its clinical relevance among egyptian breast cancer women

2021 ◽  
Author(s):  
Samah A. Loutfy ◽  
Nasra F. Abdel Fattah ◽  
Ahmed B. Barakat ◽  
Omar R. Alfarouk ◽  
Tarek M. Hashem ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Relevance ◽  
Brca1 And Brca2 ◽  
Brca2 Mutations ◽  
Brca1 And Brca2 Mutations

scholarly journals Recurrent BRCA1 and BRCA2 Mutations in Mexican Women with Breast Cancer

2014 ◽  
Vol 24 (3) ◽  
pp. 498-505 ◽  
Author(s):  
Gabriela Torres-Mejía ◽  
Robert Royer ◽  
Marcia Llacuachaqui ◽  
Mohammad R. Akbari ◽  
Anna R. Giuliano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mexican Women ◽  
Brca1 And Brca2 ◽  
Brca2 Mutations ◽  
Brca1 And Brca2 Mutations

Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Cuba

2008 ◽  
Vol 7 (3) ◽  
pp. 275-279 ◽  
Author(s):  
Rolando Comacho Rodriguez ◽  
Antonio Alejandro Esperon ◽  
Ramon Ropero ◽  
Maria Caridad Rubio ◽  
Ronald Rodriguez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Brca1 And Brca2 ◽  
Brca2 Mutations ◽  
Brca1 And Brca2 Mutations
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