scholarly journals Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine

2021 ◽  
Vol 12 (1) ◽  
pp. 27-40 ◽  
Author(s):  
Lenka Koklesova ◽  
Marek Samec ◽  
Alena Liskova ◽  
Kevin Zhai ◽  
Dietrich Büsselberg ◽  
...  
Keyword(s):  
Energy Production ◽  
Cost Effective ◽  
Organ Damage ◽  
Targeted Prevention ◽  
Multifactorial Diseases ◽  
Analytical Instruments ◽  
Individual Outcomes ◽  
Current Article ◽  
Analytical Approaches

AbstractMitochondrial injury plays a key role in the aetiopathology of multifactorial diseases exhibiting a “vicious circle” characteristic for pathomechanisms of the mitochondrial and multi-organ damage frequently developed in a reciprocal manner. Although the origin of the damage is common (uncontrolled ROS release, diminished energy production and extensive oxidative stress to life-important biomolecules such as mtDNA and chrDNA), individual outcomes differ significantly representing a spectrum of associated pathologies including but not restricted to neurodegeneration, cardiovascular diseases and cancers. Contextually, the role of predictive, preventive and personalised (PPPM/3P) medicine is to introduce predictive analytical approaches which allow for distinguishing between individual outcomes under circumstance of mitochondrial impairments followed by cost-effective targeted prevention and personalisation of medical services. Current article considers innovative concepts and analytical instruments to advance management of mitochondriopathies and associated pathologies.

scholarly journals Szabad gyökök és a máj ischaemiás-reperfúziós károsodása

2015 ◽  
Vol 156 (47) ◽  
pp. 1904-1907 ◽  
Author(s):  
Attila Szijártó
Keyword(s):  
Free Radicals ◽  
Organ Damage ◽  
Systemic Reactions ◽  
Chemical Agents ◽  
Pathophysiological Role ◽  
Polymerase Inhibitor ◽  
Current Article ◽  
Clinical Conditions

The critical importance of the ischemic-reperfusive injury is well documented with regards to numerous organs and clinical conditions. Oxygen free radicals play a central role in the mediation of the injury, which dominantly influences the prevalence of postoperative complications, (long term) organ damage, and the potential manifestation of systemic reactions. The both anatomically and pathophysiologically unique ischemic-reperfusive injury of the liver, which is expressively vulnerable to free radicals, is of utmost importance in liver surgery. Several techniques (adaptive maneuvers, chemical agents) are known to ameliorate the reperfusive injury. Based on the prior research of the workgroup of the author, the aim of the current article is to overview the set of measures capable of attenuating ischemic-reperfusive injury (ischemic preconditioning, -perconditioning, administration of adenosine, -inosine, -levosimendan, and -poly-ADP-ribose-polymerase inhibitor), with special attention to the ischemic-reperfusive injury of the liver, as well as the special pathophysiological role of free radicals in mediating hepatic damage. Orv. Hetil., 2015, 156(47), 1904–1907.

Mitochondrial matrix calcium ions regulate energy production in myocardium: A cytochemical study

1990 ◽  
Vol 48 (2) ◽  
pp. 166-167
Author(s):  
W.A. Jacob ◽  
R. Hertsens ◽  
A. Van Bogaert ◽  
M. De Smet
Keyword(s):  
Energy Metabolism ◽  
Calcium Ions ◽  
Energy Production ◽  
Regulation Of Respiration ◽  
Free Calcium ◽  
Mitochondrial Matrix ◽  
Cytochemical Study ◽  
Nmr Techniques

In the past most studies of the control of energy metabolism focus on the role of the phosphorylation potential ATP/ADP.Pi on the regulation of respiration. Studies using NMR techniques have demonstrated that the concentrations of these compounds for oxidation phosphorylation do not change appreciably throughout the cardiac cycle and during increases in cardiac work. Hence regulation of energy production by calcium ions, present in the mitochondrial matrix, has been the object of a number of recent studies.Three exclusively intramitochondnal dehydrogenases are key enzymes for the regulation of oxidative metabolism. They are activated by calcium ions in the low micromolar range. Since, however, earlier estimates of the intramitochondnal calcium, based on equilibrium thermodynamic considerations, were in the millimolar range, a physiological correlation was not evident. The introduction of calcium-sensitive probes fura-2 and indo-1 made monitoring of free calcium during changing energy metabolism possible. These studies were performed on isolated mitochondria and extrapolation to the in vivo situation is more or less speculative.

Role of Rasayana in Prevention of COVID-19 - A Review

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 716-722
Author(s):  
Sneha Dhakite ◽  
Sadhana Misar Wajpeyi
Keyword(s):  
Immune System ◽  
Respiratory System ◽  
Viral Infections ◽  
Cost Effective ◽  
The Body ◽  
Healthy Life ◽  
Vital Functions ◽  
Healthy Life Style ◽  
And Control

The “Coronavirus disease 19 (COVID-19)” is caused by “Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)”, a newly discovered member of the Coronaviridae family of viruses which is a highly communicable. There is no effective medical treatment till date for Coronavirus disease hence prevention is the best way to keep disease away. Rasayana proved to be highly efficacious and cost effective for the Prevention and Control of viral infections when vaccines and standard therapies are lacking. Rasayana Chikitsa is one of the eight branches of Ashtanga Ayurveda which helps to maintain healthy life style. Rasayana improves immunity and performs many vital functions of human body. Vyadhikshamatva that is immune mechanism of the body is involved in Prevention of the occurrence of a new disease and it also decreases the virulence and progression of an existing disease. In COVID-19 the Respiratory system mainly get affected which is evident from its symptoms like cold, cough and breathlessness. Here the drugs help in enhancing immune system and strengthening functions of Respiratory system can be useful. For this purpose, the Rasayana like Chyavanprasha, Agastya Haritaki, Pippali Rasayana, Guduchi, Yashtimadhu, Haridra, Ashwagandha, Tulsi are used. Rasayana working on Respiratory system are best for Prevention of Coronavirus and boosting immune system. Rasayana Chikitsa can be effective in the Prevention as well as reducing symptoms of COVID-19.

Monitoring of Petroleum-Related Environmental Contamination Using Fluorescence Fingerprinting

2006 ◽  
Vol 1 (2) ◽  
Author(s):  
P. Literathy ◽  
M. Quinn
Keyword(s):  
Environmental Contamination ◽  
Statistical Evaluation ◽  
Oil Pollution ◽  
Emission Spectra ◽  
Cost Effective ◽  
Petroleum Products ◽  
Danube River ◽  
Aromatic Components ◽  
Analytical Approaches

Petroleum and its refined products are considered the most complex contaminants frequently impacting the environment in significant quantities. They have heterogeneous chemical composition and alterations occur during environmental weathering. No single analytical method exists to characterize the petroleum-related environmental contamination. For monitoring, the analytical approaches include gravimetric, spectrometric and chromatographic methods having significant differences in their selectivity, sensitivity and cost-effectiveness. Recording fluorescence fingerprints of the cyclohexane extracts of the water, suspended solids, sediment or soil samples and applying appropriate statistical evaluation (e.g. by correlating the concatenated emission spectra of the fingerprints of the samples with arbitrary standards (e.g. petroleum products)), provides a powerful, cost-effective analytical tool for characterization of the type of oil pollution and detecting the most harmful aromatic components of the petroleum contaminated matrix. For monitoring purposes, the level of the contamination can be expressed as the equivalent concentration of an appropriate characteristic standard, based on the fluorescence intensities at the relevant characteristic wavelengths. These procedures are demonstrated in the monitoring of petroleum-related pollution in the water and suspended sediment in the Danube river basin

The Role of Computer Modeling in Combined Sewer Overflow Abatement Planning

1992 ◽  
Vol 26 (7-8) ◽  
pp. 1831-1840 ◽  
Author(s):  
L. A. Roesner ◽  
E. H. Burgess
Keyword(s):  
System Modeling ◽  
Cost Effective ◽  
Combined Sewer Overflows ◽  
Sewer System ◽  
New Techniques ◽  
Hydraulic Simulation ◽  
Continuous Simulation ◽  
Combined Sewer ◽  
The U.S

Increased concern regarding water quality impacts from combined sewer overflows (CSOs) in the U.S. and elsewhere has emphasized the role of computermodeling in analyzing CSO impacts and in planning abatement measures. These measures often involve the construction of very large and costly facilities, and computer simulation during plan development is essential to cost-effective facility sizing. An effective approach to CSO system modeling focuses on detailed hydraulic simulation of the interceptor sewers in conjunction with continuous simulation of the combined sewer system to characterize CSOs and explore storage-treatment tradeoffs in planning abatement facilities. Recent advances in microcomputer hardware and software have made possible a number of new techniques which facilitate the use of computer models in CSO abatement planning.

Natural Tyrosinase Inhibitors: Role of Herbals in the Treatment of Hyperpigmentary Disorders

2019 ◽  
Vol 19 (10) ◽  
pp. 796-808 ◽  
Author(s):  
Kamal Uddin Zaidi ◽  
Sharique A. Ali ◽  
Ayesha Ali ◽  
Ishrat Naaz
Keyword(s):  
Critical Role ◽  
Enzymatic Browning ◽  
Melanin Production ◽  
Natural Sources ◽  
Pigmentary Disorders ◽  
Normal Manner ◽  
Abnormal Accumulation ◽  
Current Article ◽  
Tyrosinase Inhibitors

Cutaneous pigmentation plays critical role in determining the color of skin along with photo protection of skin from dreadful effects of ultraviolet radiations. Conversely, abnormal accumulation of melanin is responsible for hyper pigmentary disorders such as melasma, senile lentigines and freckles. Because of the visible nature of dermatologic diseases, they have a considerable psychosomatic effect on affected patients. Tyrosinase inhibitors are molecules that interrelate in some way with the enzyme to prevent it from working in the normal manner. Past many decades witnessed the quest for the development of natural tyrosinase inhibitors due to imperative role played by tyrosinase in the process of melanogenesis and fungi or fruit enzymatic browning. Mechanism of pigmentation is characterized by the intact process of the synthesis of specialized black pigment within melanosomes. Melanin is synthesized by a cascade of enzymatic and chemical reactions. For this reason, melanin production is mainly controlled by the expression and activation of tyrosinase. In the current article, we discussed tyrosinase inhibitors from the natural sources, which can be an essential constituent of cosmetics products and depigmenting agents for the treatment of hyperpigmentory disorders.

Green synthesis of silver nanoparticles using sustainable resources and their use as antibacterial agents: A review

2020 ◽  
Vol 13 ◽  
Author(s):  
Kumari Jyoti ◽  
Punyasloka Pattnaik ◽  
Tej Singh
Keyword(s):  
Silver Nanoparticles ◽  
Plant Extracts ◽  
Metallic Nanoparticles ◽  
Cost Effective ◽  
Biological Properties ◽  
Metal Species ◽  
Sustainable Resources ◽  
Research Areas ◽  
Low Toxicity

Background:: Synthesis of metallic nanoparticles has attracted extensive vitality in numerous research areas such as drug delivery, biomedicine, catalysis etc. where continuous efforts are being made by scientists and engineers to investigate new dimensions for both technological and industrial advancements. Amongst numerous metallic nanoparticles, silver nanoparticle (AgNPs) is a novel metal species with low toxicity, higher stability and significant chemical, physical and biological properties. Methods:: In this, various methods for the fabrication of AgNPs are summarized. Importantly, we concentrated on the role of reducing agents of different plants parts, various working conditions such as AgNO3 concentration; ratio of AgNO3/extract; incubation time; centrifugal conditions, size and shapes. Results:: This study suggested that eco-friendly and non toxic biomolecules present in the extracts (e.g. leaf, stem and root) of plants are used as reducing and capping agents for silver nanoparticles fabrication. This method of fabrication of silver nanoparticles using plants extracts is comparatively cost-effective and simple. A silver salt is simply reduced by biomolecules present in the extracts of these plants. In this review, we have emphasized the synthesis and antibacterial potential of silver nanoparticles using various plant extracts. Conclusion:: Fabrication of silver nanoparticles using plant extracts have advantage over the other physical methods, as it is safe, eco-friendly and simple to use. Plants have huge potential for the fabrication of silver nanoparticles of wide potential of applications with desired shape and size.

scholarly journals Peripheral Leukocytosis Predicts Cognitive Decline but Not Behavioral Disturbances: A Nationwide Study of Alzheimer’s and Parkinson’s Disease Patients

2021 ◽  
pp. 1-10
Author(s):  
Santiago R. Unda ◽  
Aldana M. Antoniazzi ◽  
David J. Altschul ◽  
Roberta Marongiu
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Psychological Symptoms ◽  
Inflammatory Marker ◽  
White Blood Cells ◽  
Cost Effective ◽  
International Classification Of Diseases ◽  
Behavioral Disturbances ◽  
Classification Of Diseases

<b><i>Introduction:</i></b> Peripheral and central nervous system inflammation have been linked to the classic symptoms of Parkinson’s disease (PD) and Alzheimer’s disease (AD). However, it remains unclear whether the analysis of routine systemic inflammatory markers could represent a useful prediction tool to identify clinical subtypes in patients with Parkinson’s and Alzheimer’s at higher risk of dementia-associated symptoms, such as behavioral and psychological symptoms of dementia (BPSD). <b><i>Methods:</i></b> We performed a multivariate logistic regression using the 2016 and 2017 National Inpatient Sample with International Classification of Diseases 10th edition codes to assess if pro-inflammatory white blood cells (WBCs) anomalies correlate with dementia and BPSD in patients with these disorders. <b><i>Results:</i></b> We found that leukocytosis was the most common WBC inflammatory marker identified in 3.9% of Alzheimer’s and 3.3% Parkinson’s patients. Leukocytosis was also found to be an independent risk factor for Parkinson’s dementia. Multivariate analysis of both cohorts showed that leukocytosis is significantly decreased in patients with BPSD compared to patients without BPSD. <b><i>Conclusions:</i></b> These results suggest a link between leukocytosis and the pathophysiology of cognitive dysfunction in both PD and AD. A better understanding of the role of systemic neuroinflammation on these devastating neurodegenerative disorders may facilitate the development of cost-effective blood biomarkers for patient’s early diagnosis and more accurate prognosis.

scholarly journals Phytoextraction of Lead Using a Hedge Plant [Alternanthera bettzickiana (Regel) G. Nicholson]: Physiological and Biochemical Alterations through Bioresource Management

2021 ◽  
Vol 13 (9) ◽  
pp. 5074
Author(s):  
Urooj Kanwal ◽  
Muhammad Ibrahim ◽  
Farhat Abbas ◽  
Muhammad Yamin ◽  
Fariha Jabeen ◽  
...  
Keyword(s):  
Citric Acid ◽  
Growth Parameters ◽  
Cost Effective ◽  
Dry Weight ◽  
Citric Acid Concentration ◽  
Biochemical Alterations ◽  
Biomass Plant ◽  
Environmentally Friendly Approach ◽  
Pb Concentration

Phytoremediation is a cost-effective and environmentally friendly approach that can be used for the remediation of metals in polluted soil. This study used a hedge plant–calico (Alternanthera bettzickiana (Regel) G. Nicholson) to determine the role of citric acid in lead (Pb) phytoremediation by exposing it to different concentrations of Pb (0, 200, 500, and 1000 mg kg−1) as well as in a combination with citric acid concentration (0, 250, 500 µM). The analysis of variance was applied on results for significant effects of the independent variables on the dependent variables using SPSS (ver10). According to the results, maximum Pb concentration was measured in the upper parts of the plant. An increase in dry weight biomass, plant growth parameters, and photosynthetic contents was observed with the increase of Pb application (200 mg kg−1) in soil while a reduced growth was experienced at higher Pb concentration (1000 mg kg−1). The antioxidant enzymatic activities like superoxide dismutase (SOD) and peroxidase (POD) were enhanced under lower Pb concentration (200, 500 mg kg−1), whereas the reduction occurred at greater metal concentration Pb (1000 mg kg−1). There was a usual reduction in electrolyte leakage (EL) at lower Pb concentration (200, 500 mg kg−1), whereas EL increased at maximum Pb concentration (1000 mg kg−1). We concluded that this hedge plant, A. Bettzickiana, has the greater ability to remediate polluted soils aided with citric acid application.

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