Designed Nanoporous Solids for the Green Production of Vitamins, Fine Chemicals and Renewable Nylons

2009 ◽  
Vol 52 (3) ◽  
pp. 322-332 ◽  
Author(s):  
Robert Raja
Keyword(s):  
Fine Chemicals ◽  
Green Production ◽  
Nanoporous Solids

scholarly journals Catalytically self-sufficient cytochromes P450 for green production of fine chemicals

2016 ◽  
Vol 28 (S1) ◽  
pp. 169-181 ◽  
Author(s):  
Alberto Ciaramella ◽  
Daniela Minerdi ◽  
Gianfranco Gilardi
Keyword(s):  
Cytochromes P450 ◽  
Fine Chemicals ◽  
Green Production

Formic Acid: A Promising Bio-Renewable Feedstock for Fine Chemicals

2012 ◽  
Vol 354 (17) ◽  
pp. 3180-3186 ◽  
Author(s):  
Manuel G. Mura ◽  
Lidia De Luca ◽  
Giampaolo Giacomelli ◽  
Andrea Porcheddu
Keyword(s):  
Formic Acid ◽  
Fine Chemicals ◽  
Renewable Feedstock

scholarly journals Nitrile Synthesis with Aldoxime Dehydratases: A Biocatalytic Platform with Applications in Asymmetric Synthesis, Bulk Chemicals, and Biorefineries

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4466
Author(s):  
Pablo Domínguez de María
Keyword(s):  
Asymmetric Synthesis ◽  
Organic Solvents ◽  
Raw Materials ◽  
Aqueous Media ◽  
Industrial Processes ◽  
Polymer Chemistry ◽  
Fine Chemicals ◽  
Mild Conditions ◽  
Bulk Chemicals ◽  
Recent Developments

Nitriles comprise a broad group of chemicals that are currently being industrially produced and used in fine chemicals and pharmaceuticals, as well as in bulk applications, polymer chemistry, solvents, etc. Aldoxime dehydratases catalyze the cyanide-free synthesis of nitriles starting from aldoximes under mild conditions, holding potential to become sustainable alternatives for industrial processes. Different aldoxime dehydratases accept a broad range of aldoximes with impressive high substrate loadings of up to >1 Kg L−1 and can efficiently catalyze the reaction in aqueous media as well as in non-aqueous systems, such as organic solvents and solvent-free (neat substrates). This paper provides an overview of the recent developments in this field with emphasis on strategies that may be of relevance for industry and sustainability. When possible, potential links to biorefineries and to the use of biogenic raw materials are discussed.

scholarly journals Green Production of Cladribine by Using Immobilized 2′-Deoxyribosyltransferase from Lactobacillus delbrueckii Stabilized through a Double Covalent/Entrapment Technology

Biomolecules ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 657
Author(s):  
Cintia Wanda Rivero ◽  
Natalia Soledad García ◽  
Jesús Fernández-Lucas ◽  
Lorena Betancor ◽  
Gustavo Pablo Romanelli ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Enzymatic Synthesis ◽  
Calcium Alginate ◽  
Covalent Immobilization ◽  
Chemical Processes ◽  
Lactobacillus Delbrueckii ◽  
Proof Of Concept ◽  
Enzymatic Production ◽  
Green Production ◽  
Efficient Alternative

Nowadays, enzyme-mediated processes offer an eco-friendly and efficient alternative to the traditional multistep and environmentally harmful chemical processes. Herein we report the enzymatic synthesis of cladribine by a novel 2′-deoxyribosyltransferase (NDT)-based combined biocatalyst. To this end, Lactobacillus delbrueckii NDT (LdNDT) was successfully immobilized through a two-step immobilization methodology, including a covalent immobilization onto glutaraldehyde-activated biomimetic silica nanoparticles followed by biocatalyst entrapment in calcium alginate. The resulting immobilized derivative, SiGPEI 25000-LdNDT-Alg, displayed 98% retained activity and was shown to be active and stable in a broad range of pH (5–9) and temperature (30–60 °C), but also displayed an extremely high reusability (up to 2100 reuses without negligible loss of activity) in the enzymatic production of cladribine. Finally, as a proof of concept, SiGPEI 25000-LdNDT-Alg was successfully employed in the green production of cladribine at mg scale.

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