Wnt/PCP signalling cascade disruption by JNK inhibition as a potential mechanism underlying the teratogenic effects of potato glycoalkaloids

2020 ◽  
Vol 47 (11) ◽  
pp. 9235-9238
Author(s):  
Andrea Cuschieri ◽  
Jean Calleja-Agius
Keyword(s):  
Potential Mechanism ◽  
Teratogenic Effects ◽  
Potato Glycoalkaloids ◽  
Signalling Cascade

Emotional Impact Feedback Changes How We Remember Negative Autobiographical Experiences

2010 ◽  
Vol 57 (5) ◽  
pp. 354-359 ◽  
Author(s):  
Melanie K. T. Takarangi ◽  
Deryn Strange
Keyword(s):  
Well Being ◽  
The Other ◽  
Personal Perspective ◽  
Emotional Impact ◽  
Potential Mechanism ◽  
Negative Experiences ◽  
Negative Memory ◽  
The Relationship ◽  
Negative Memories ◽  
Over Time

When people are told that their negative memories are worse than other people’s, do they later remember those events differently? We asked participants to recall a recent negative memory then, 24 h later, we gave some participants feedback about the emotional impact of their event – stating it was more or less negative compared to other people’s experiences. One week later, participants recalled the event again. We predicted that if feedback affected how participants remembered their negative experiences, their ratings of the memory’s characteristics should change over time. That is, when participants are told that their negative event is extremely negative, their memories should be more vivid, recollected strongly, and remembered from a personal perspective, compared to participants in the other conditions. Our results provide support for this hypothesis. We suggest that external feedback might be a potential mechanism in the relationship between negative memories and psychological well-being.

Low vitamin D is associated with increased bladder cancer risk; a systematic review and evidence of a potential mechanism

2016 ◽  
Author(s):  
Rosemary Bland ◽  
Corina Chivu ◽  
Kieran Jefferson ◽  
Donald MacDonald ◽  
Gulnaz Iqbal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Bladder Cancer ◽  
Cancer Risk ◽  
Potential Mechanism ◽  
Bladder Cancer Risk

1878-P: The Role and Potential Mechanism of LncRNA Gm15441 in Skeletal Muscle Glucose and Lipid Metabolism

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1878-P
Author(s):  
LIANGHUI YOU ◽  
YU ZENG ◽  
NAN GU ◽  
CHENBO JI
Keyword(s):  
Skeletal Muscle ◽  
Lipid Metabolism ◽  
Potential Mechanism ◽  
Glucose And Lipid Metabolism

The use of progesterone during pregnancy in women with epilepsy as an alternative to the correction of doses of anticonvulsants

GYNECOLOGY ◽  
2020 ◽  
Vol 21 (6) ◽  
pp. 12-15
Author(s):  
Elena V. Tsallagova ◽  
Vasily O. Generalov ◽  
Timur R. Sadykov
Keyword(s):  
Clinical Remission ◽  
Epileptic Seizures ◽  
Progesterone Concentration ◽  
Teratogenic Effects ◽  
Safe Alternative ◽  
Patients With Epilepsy

Pregnancy is the most dangerous period in terms of interruption of even persistent and long-term remission. At the same time increasing the dose of anticonvulsant increases the risk of teratogenic effects. Aim. to assess the possibility of using progesterone to prevent relapse of epileptic seizures during pregnancy. Materials and methods. 38 pregnant patients with epilepsy with clinical remission before pregnancy, with relapse of epileptic seizures in I trimester of pregnancy, age 31.81.4 years. Dydrogesterone in a dose of 10 to 60 mg/day was prescribed after the relapse of remission. Anticonvulsant dosage was not changed. The blood progesterone concentration and EEG control was carried out. Results. During pregnancy, the level of progesterone in the blood gradually increased from 77.8 nmol/l at 78 weeks of pregnancy to 521.1 nmol/l at 3637 weeks of pregnancy, without exceeding the limits. EEG results did not deteriorate. None of the patients had seizures during pregnancy. Conclusion. Progesterone therapy is an adequate and safe alternative to increasing the dose of anticonvulsants in case of recurrent seizures during pregnancy.

Beauty and truth, truth and beauty: Chiasmus and the Keats heuristic

2020 ◽  
Author(s):  
Mane Kara-Yakoubian ◽  
Alexander C. Walker ◽  
Constantine Sharpinskyi ◽  
Garni Assadourian ◽  
Jonathan Albert Fugelsang
Keyword(s):  
Specific Form ◽  
Current Work ◽  
Reverse Order ◽  
Potential Mechanism

The Keats heuristic suggests that people find aesthetically pleasing expressions more accurate than mundane expressions. We test this notion with chiastic statements. Chiasmus is a stylistic phenomenon in which at least two linguistic constituents are repeated in reverse order, following an A-B-B-A pattern. Our study focuses on the specific form of chiasmus known as antimetabole, in which the reverse-repeated constituents are words (e.g., “all for one and one for all”). In 3 out of 4 experiments (N = 797), we find evidence that people judge antimetabolic statements (e.g., “Success is getting what you want. Happiness is wanting what you get.”) as more accurate than semantically equivalent non-antimetabolic statements (e.g., “Success is getting what you wish. Happiness is wanting what you receive.”). Furthermore, we evaluate fluency as a potential mechanism explaining the observed accuracy benefit afforded to antimetabolic statements, finding that the increased speed (i.e., fluency) with which antimetabolic statements were processed was misattributed by participants as evidence of greater accuracy. Overall, the current work demonstrates that stylistic factors bias assessments of truth, with information communicated using aesthetically pleasing stylistic devices (e.g., antimetabole) being perceived as more truthful.

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