Hypericum perforatum L.: a medicinal plant with potential as a curative agent against obesity-associated complications

2020 ◽  
Vol 47 (11) ◽  
pp. 8679-8686
Author(s):  
Hilal Büşra Tokgöz ◽  
Filiz Altan
Keyword(s):  
Medicinal Plant ◽  
Hypericum Perforatum ◽  
Hypericum Perforatum L ◽  
Curative Agent

scholarly journals Variation in phytochemical properties and expression of key genes involved in biosynthesis of hypericin using nano-capsulated and normal hormones in Hypericum perforatum L

2021 ◽  
Author(s):  
Leila Ghodrati ◽  
Mehrdad Ataie Kachoie ◽  
Shima Gharibi
Keyword(s):  
Normal Form ◽  
Medicinal Plant ◽  
Hplc Analysis ◽  
Hypericum Perforatum ◽  
Expression Patterns ◽  
Qrt Pcr ◽  
Germacrene D ◽  
Hypericum Perforatum L ◽  
Key Genes

Abstract Hypericum perforatum is a valuable medicinal plant with anti-depressant activity. Hypericin is the major compound responsible for such activity. In the present study, the effect of four nano-capsulated hormones of 2,4-epibrassinolide, spermidine, salycilic acid and cycocel were investigated on the amount of hypericin based on HPLC analysis in two locations (Saman and Isfahan). For each hormone, the normal form was also compared with nano form. The expression patterns of the key genes (Hyp-1, pks1, pks2) for hypericin production was also evaluated using qRT-PCR. Moreover, GC-MS analysis was also performed for determination of the compounds in studied treatments. The major compounds were germacrene D (3.29–33.53%), β-caryophyllene (0-4.08) and α-longipinene (0-24.05%). In most cases, nano-hormones led to increase in these components. Significant changes were obtained in expression of key genes in hypericin synthesis as a result of nano-hormones treatments in Isfahan site. Overall, nano-hormones revealed higher increase in expression of all genes as compared with normal hormones in this site. The expression of Hyp-1, Pks1 and Pks2 was significantly increased using spermidine, 24-epibrassinolide and cycocel in Isfahan location in both nano-hormones and normal ones, while the expression of Hyp-1 was decreased in SA treatment in Isfahan location. Based on HPLC analysis, hypericin ranged from 0.21 in control to 0.51 mg 100 g− 1 DW in nano-SA in Isfahan site. Finally, the expression of the key genes were mostly elevated in colder climates and nano-form formulation.

St. John’s wort (Hypericum perforatum L.): Challenges and strategies for production of chemically-consistent plants

2006 ◽  
Vol 86 (3) ◽  
pp. 765-771 ◽  
Author(s):  
Susan J. Murch ◽  
Praveen K. Saxena
Keyword(s):  
Medicinal Plant ◽  
Large Scale ◽  
Hypericum Perforatum ◽  
Controlled Environment ◽  
Natural Health Products ◽  
Scale Production ◽  
Plant Products ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L

Plants are by far the most important source of natural therapeutics, and the role of plants in enhancing the longevity and the quality of life is increasingly accepted throughout the world. A series of problems with medicinal plant products, such as contamination with biological and environmental pollutants, quantitative and qualitative variations of bioactive compounds, adulteration with misidentified species, and the concern of unsustainable harvest, has prompted the introduction of regulations to ensure the quality and safety of medicinal plant products in Canada. In the future, Natural Health Products in Canada will be manufactured to a new standard of quality and these changes in the industry have necessitated new approaches to the breeding, production, and processing of medicinal plant tissues. The continuing growth in the medicinal plant marketplace has also brought about the challenge of maintaining a balance between consumer demand and the need to protect medicinal biodiversity. St. John’s wort (Hypericum perforatum L.) is one of the most popular medicinal plants with a history of use spanning more than two millennia and modern studies demonstrating efficacy. However, inconsistencies in the results of various clinical trials and difficulties in identifying a specific medicinal molecule with defined pharmaceutical function prompted our efforts to improve St. John’s wort products. Development of elite varieties with predictable phytochemical profiles, mass clonal propagation in vitro, large-scale production in sterile environments and controlled environment production systems, have been combined to produce a new standard in the production of St. John’s wort. Key words: St. John's wort, chemical consistency, hyperforin, melatonin, controlled environment systems

Determination of Hypericin in St. John's Wort (Hypericum perforatum L.) extracts using HPLC-ED

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
E Sofic ◽  
A Copra Janicijevic ◽  
M Maksimovic ◽  
I Tahirovic ◽  
L Klepo ◽  
...  
Keyword(s):  
Hypericum Perforatum ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L

Protective Effect of Hypericum perforatum L. Extract on Hexavalent Chromium Induced Toxicity in Rat Adrenal Gland

2017 ◽  
Vol 68 (9) ◽  
pp. 2014-2017
Author(s):  
Jelena Savici ◽  
Oana Maria Boldura ◽  
Cornel Balta ◽  
Diana Brezovan ◽  
Florin Muselin ◽  
...  
Keyword(s):  
Drinking Water ◽  
Adrenal Gland ◽  
Hexavalent Chromium ◽  
Structural Damage ◽  
Hypericum Perforatum ◽  
Adrenal Glands ◽  
Expression Level ◽  
Apoptotic Pathway ◽  
Hypericum Perforatum L ◽  
Induction Of Apoptosis

This study was carried out to test the possibility of hexavalent chromium administration through drinking water to induce the structural damage in rat�s adrenal glands and the possibility of Hypericum perforatum extract to faith against chromium aggression. Chromium induced cellular stress was determined by the expression level assessment of the Bcl2 genes family, known to modulate the apoptotic pathway. Obtained results showed that exposure to chromium altered adrenal glands morphology, by induction of apoptosis. When Hypericum perforatum extract was administered expression level of Bcl2 genes and histological lesions in adrenal glands were significantly reduced.

Evaluating the Content of Active Principles from Wild Hypericum perforatum L. in Various Harvesting Seasons

2018 ◽  
Vol 69 (7) ◽  
pp. 1892-1897
Author(s):  
Elena Ionescu ◽  
Tanta Verona Iordache ◽  
Carmen Elena Tebrencu ◽  
Ruxandra Mihaela Cretu ◽  
Ana Mihaela Florea ◽  
...  
Keyword(s):  
Plant Material ◽  
Hypericum Perforatum ◽  
Hypericum Perforatum L

Hypericum perforatum L., traditionally called St. John�s Wort has been used for decades as a phyto-therapeutic herb due to antidepressant, antimicrobial and antiseptic properties. As a result, the presented study evaluates the influence of the harvesting season for the Hypericum perforatum L. plant material, which is crucial for obtaining significant amounts of active principles.

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