Managing Patients with Inflammatory Bowel Disease Who Develop Prostate Cancer

2019 ◽  
Vol 65 (1) ◽  
pp. 22-30 ◽  
Author(s):  
Jaehyun Kim ◽  
Linda A. Feagins
Keyword(s):  
Prostate Cancer ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Develop Prostate Cancer ◽  
Inflammatory Bowel

scholarly journals Androgen Deprivation Therapy and the Incidence of Inflammatory Bowel Disease in Patients With Prostate Cancer

2016 ◽  
Vol 184 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Adi J. Klil-Drori ◽  
Koray Tascilar ◽  
Hui Yin ◽  
Armen Aprikian ◽  
Alain Bitton ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Inflammatory Bowel Disease ◽  
Androgen Deprivation Therapy ◽  
Bowel Disease ◽  
Androgen Deprivation ◽  
Inflammatory Bowel

Inflammatory bowel disease and the risk of prostate cancer.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e17052-e17052
Author(s):  
Shilajit Kundu ◽  
Jacob A Burns ◽  
Adam Benjamin Weiner ◽  
William Catalona ◽  
Edward M. Schaeffer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Inflammatory Bowel Disease and the Risk of Prostate Cancer

2019 ◽  
Vol 75 (5) ◽  
pp. 846-852 ◽  
Author(s):  
Jacob A. Burns ◽  
Adam B. Weiner ◽  
William J. Catalona ◽  
Eric V. Li ◽  
Edward M. Schaeffer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals MP16-19 MODELING THE IMPACT OF INFLAMMATORY BOWEL DISEASE ON PROSTATE CANCER RISK IN MICE

2020 ◽  
Vol 203 ◽  
pp. e222-e223
Author(s):  
Anuj Desai* ◽  
Barbara Lysy ◽  
Vinay Sagar ◽  
Rajita J Vatapalli ◽  
HuiYing Han ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Inflammatory Bowel Disease ◽  
Cancer Risk ◽  
Bowel Disease ◽  
Prostate Cancer Risk ◽  
Inflammatory Bowel ◽  
The Impact

Inflammatory bowel disease and risk of prostate cancer: A matched-cohort analysis.

2019 ◽  
Vol 37 (7_suppl) ◽  
pp. 55-55
Author(s):  
Adam Weiner ◽  
Jacob A Burns ◽  
William J Catalona ◽  
Eric Li ◽  
Edward M. Schaeffer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Cohort Analysis ◽  
Specific Antigen ◽  
Gleason Grade ◽  
Starting Point ◽  
Inflammatory Bowel ◽  
Clinically Significant

55 Background: There are few data on the risk of prostate cancer (PCa) in men with inflammatory bowel disease (IBD) and there are no data comparing serum prostate-specific antigen (PSA) values between men with IBD and matched men without IBD. Methods: This study retrospectively matched men with IBD based on race and age 1 to 9 to men without IBD (controls) who underwent PCa screening with at least one PSA at a single academic medical center from 1996 to 2017. Kaplan-Meier and multivariable Cox analyses were used to compare the risk of any and clinically significant PCa (Gleason grade group > 1) between the two groups adjusting for number of PSA tests, abnormal rectal exam, age, and race. A mix-effects regression was used to assess the association between PSA and IBD status. Results: After a median follow-up of 6.5 years for 1,033 men with IBD and 4.7 years for 9,306 controls, the median number of PSA tests was 2, 74% were white, and median age at first PSA (starting point of follow-up) was 53 years. At 10 years of follow-up, the incidence of any PCa was 0.65% for controls and 4.4% for men with IBD (HR 4.37, 95% CI 3.08-6.19, p < 0.001) and of clinically significant PCa was 0.42% for controls and 2.4% for men with IBD (HR 3.78, 95% CI 2.40-5.96, p < 0.001). When only men with IBD were assessed, use of biologic medications, duration of IBD diagnosis, history of bowel resection, Crohn’s disease versus ulcerative colitis were not associated with PCa diagnoses (all p > 0.1). Any steroid treatment for IBD was associated with decreased incidence of any PCa (HR 0.22, 95% CI 0.06-0.78, p = 0.019), but not with clinically significant PCa (p = 0.5). PSA values were higher among men with IBD starting at age 60 (1.12 ng/mL vs 1.04 ng/mL, p = 0.031) and this gap widened with increasing age (age 70: 1.54 ng/mL vs 1.32 ng/mL, p = 0.007). Conclusions: Men with IBD being screened for PCa had an increased incidence of all and clinically significant PCa compared to age- and race-matched controls and had increased PSA values at older age. These findings should be further validated to consider IBD as a risk factor for PCa and optimize screening for this population.

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