Correlation of the myocardial performance index with plasma B-type natriuretic peptide levels in patients with mitral regurgitation

2007 ◽  
Vol 24 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Nurten Sayar ◽  
A. Lütfullah Orhan ◽  
Nazmiye Çakmak ◽  
Hale Yılmaz ◽  
Hüsnü Atmaca ◽  
...  
Keyword(s):  
Mitral Regurgitation ◽  
Natriuretic Peptide ◽  
Performance Index ◽  
Myocardial Performance Index ◽  
Myocardial Performance

Myocardial performance after successful intervention for native aortic coarctation

2010 ◽  
Vol 20 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Vedide Tavli ◽  
Turkay Saritas ◽  
Baris Guven ◽  
Faik Okur ◽  
Berna Cevik Saylan ◽  
...  
Keyword(s):  
Natriuretic Peptide ◽  
Performance Index ◽  
Aortic Coarctation ◽  
Left Ventricular ◽  
Myocardial Performance Index ◽  
Myocardial Performance ◽  
Left Ventricular Performance ◽  
Ventricular Performance ◽  
Endothelin 1 ◽  
Isovolumic Relaxation

AbstractCoarctation of the aorta is associated with increased risk for hypertension in adulthood, despite successful repair. The intrinsic mechanisms underscoring hypertension and left ventricular performance in these patients, however, remains to be determined. Our objective was to evaluate left ventricular performance by means of echocardiographic and biochemical parameters at midterm follow-up in normotensive children who have had undergone successful surgical or catheter interventional treatment of coarctation with a residual gradient of less than 20 mmHg at rest. We studied prospectively 14 patients with native aortic coarctation who underwent surgery or balloon angioplasty, the cohort made up of equal numbers of boys and girls, and having a mean age of 8.5 plus or minus 4 years. We also studied 30 age-matched healthy subjects, measuring mitral inflow pulsed wave signals, isovolumic relaxation and contraction times, myocardial performance index parameters, and levels of B-type natriuretic peptide and endothelin-1 in both groups. We found no differences in systolic blood pressure at rest between the patients and their controls. The ventricular septal diastolic dimensions, left ventricular posterior wall dimensions, mitral valve E wave, deceleration time, isovolumic relaxation time, isovolumic contraction time and myocardial performance index were all significantly increased in the patients. Levels of plasma B-type natriuretic peptide and endothelin-1 were also significantly higher in the patients when compared to the control group. We conclude that aortic coarctation is a chronic disease characterized by persistency of myocardial and vascular alterations. The elevated levels of plasma b-type natriuretic peptide and endothelin-1 may be indicative of late onset hypertension after successful treatment of native coarctation in early childhood.

scholarly journals Comparison of N-Terminal Pro B-Natriuretic Peptide and Echocardiographic Indices in Patients with Mitral Regurgitation

2010 ◽  
Vol 4 ◽  
pp. CMC.S6062
Author(s):  
Shokoufeh Hajsadeghi ◽  
Niloufar Samiei ◽  
Masoud Moradi ◽  
Maleki Majid ◽  
Ladan Kashani ◽  
...  
Keyword(s):  
Plasma Level ◽  
Serum Level ◽  
Mitral Regurgitation ◽  
Natriuretic Peptide ◽  
Doppler Echocardiography ◽  
Performance Index ◽  
Left Ventricular ◽  
Myocardial Performance ◽  
Lv Dysfunction ◽  
Dead End

Introduction Echocardiographic indices can form the basis of the diagnosis of systolic and diastolic left ventricular (LV) dysfunction in patients with Mitral regurgitation (MR). However, using echocardiography alone may bring us to a diagnostic dead-end. The aim of this study was to compare N-Terminal pro B-natriuretic peptide (BNP) and echocardiographic indices in patients with mitral regurgitation. Methods 2D and Doppler echocardiography and BNP serum level were obtained from 54 patients with organic mild, moderate and severe MR. Results BNP levels were increased with symptoms in patients with mitral regurgitation (NYHAI: 5.7 ± 1.1, NYHAII: 6.9 ± 1.5, NYHAIII: 8.3 ± 2 pg/ml, P < 0.001). BNP plasma level were significantly correlated with MPI (myocardial performance index) (r = 0.399, P = 0.004), and following echocardiographic indices: LVEDV (r = 0.45, P < 0.001), LVESV (r = 0.54, P < 0.001), LVEDD (r = 0.48, P < 0.001), LVESD (r = 0.54, P < 0.001), dp/dt (r = −0.32, P = 0.019) and SPAP (r = 0.4, P = 0.006). Conclusion The present study showed that BNP may be useful in patients with MR and may confirm echocardiographic indices.

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