Effect of macrophage colony stimulating factor overexpression on oxidative injury/resistance of RAW264.7 cells

2003 ◽  
Vol 3 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Z.-J. Pang
Keyword(s):  
Oxidative Injury ◽  
Raw264.7 Cells ◽  
Colony Stimulating Factor ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Effect of Polysaccharide Krestin on the Up-regulation of Macrophage Colony-Stimulating Factor Gene Expression in Protecting Mouse Peritoneal Macrophages from Oxidative Injury

2003 ◽  
Vol 31 (01) ◽  
pp. 11-23 ◽  
Author(s):  
Zhan-Jun Pang
Keyword(s):  
Gene Expression ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Oxidative Injury ◽  
Peritoneal Macrophages ◽  
Colony Stimulating Factor ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Mouse Peritoneal Macrophages ◽  
Stimulating Factor

Oxidative injury caused by oxidatively modified low density lipoprotein (Ox-LDL) plays an important role in the transformation of macrophages into foam cells and atherogenesis. Treatments to protect macrophages from oxidative injury will be effective in treating atherosclerosis. A macrophage-specific growth factor, macrophage colony-stimulating factor (M-CSF), was reported to be able to prevent the progression of atherosclerosis in Watanabe heritable hypercholesterolemic (WHHL) rabbits. A protein-bound polysaccharide, polysaccharide Krestin (PSK), was also proven to have effects in preventing atherosclerosis in our previous work. We proposed that, both M-CSF and PSK could protect macrophages from oxidative injury, and the effects of PSK were associated with its capability of inducing M-CSF expression. In our present results, M-CSF could alleviate the Ox-LDL- or tert-butyl hydroperoxide (tbOOH)-induced injury to mouse peritoneal macrophages, and PSK exhibited some similar effects. PSK treatment could induce M-CSF gene expression and secretion in mouse peritoneal macrophages. Furthermore, actinomycin D and cycloheximide could attenuate that induction. We concluded that, maybe PSK exerted its effects on macrophages partly through the transcriptional induction of M-CSF in the cells.

Interleukin-34 and macrophage-colony stimulating factor interact to form a heteromeric and functional cytokine

2014 ◽  
Author(s):  
Aude Segaliny ◽  
Regis Brion ◽  
Benedicte Brulin ◽  
Stephane Teletchea ◽  
Julien Jardin ◽  
...  
Keyword(s):  
Colony Stimulating Factor ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor
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