Investigating the reference domain influence in personalised models of cardiac mechanics

2021 ◽  
Author(s):  
Myrianthi Hadjicharalambous ◽  
Christian T. Stoeck ◽  
Miriam Weisskopf ◽  
Nikola Cesarovic ◽  
Eleftherios Ioannou ◽  
...  
Keyword(s):  
Cardiac Mechanics ◽  
Reference Domain

Associations of Cardiac Mechanics with Exercise Capacity: The Multi-Ethnic Study of Atherosclerosis

2021 ◽  
Author(s):  
Ravi B. Patel ◽  
Benjamin H. Freed ◽  
Lauren Beussink-Nelson ◽  
Norrina B. Allen ◽  
Suma H. Konety ◽  
...  
Keyword(s):  
Exercise Capacity ◽  
Cardiac Mechanics ◽  
Ethnic Study

scholarly journals CARDIAC MECHANICS AND SUBMAXIMAL EXERCISE CAPACITY IN THE COMMUNITY: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS

2021 ◽  
Vol 77 (18) ◽  
pp. 1293
Author(s):  
Ravi B. Patel ◽  
Benjamin Freed ◽  
Lauren Nelson ◽  
Norrina Allen ◽  
Suma Konety ◽  
...  
Keyword(s):  
Exercise Capacity ◽  
Cardiac Mechanics ◽  
Submaximal Exercise ◽  
Ethnic Study

scholarly journals 2D cine DENSE with low encoding frequencies accurately quantifies cardiac mechanics with improved image characteristics

2015 ◽  
Vol 17 (1) ◽  
Author(s):  
Gregory J. Wehner ◽  
Jonathan D. Grabau ◽  
Jonathan D. Suever ◽  
Christopher M. Haggerty ◽  
Linyuan Jing ◽  
...  
Keyword(s):  
Cardiac Mechanics ◽  
Image Characteristics ◽  
Cine Dense

scholarly journals ADVANCED PARAMETERS OF CARDIAC MECHANICS IN CHILDREN WITH CHRONIC KIDNEY DISEASE: THE 4C STUDY

2014 ◽  
Vol 63 (12) ◽  
pp. A1098
Author(s):  
Marcello Chinali ◽  
Alessio Franceschini ◽  
MariaChiara Matteucci ◽  
Doyon Anke ◽  
Claudia Esposito ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiac Mechanics

Abstract 17184: CMR Derived Myocardial Mechanics in Patients With Systemic Sarcoidosis

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Veronica Rolim S. Fernandes ◽  
Beatriz Jauregui Garrido ◽  
Maria E Siqueira ◽  
Jonathan Katz ◽  
Adam Jacobi ◽  
...  
Keyword(s):  
Myocardial Dysfunction ◽  
Myocardial Strain ◽  
Prognostic Significance ◽  
Cardiac Mechanics ◽  
Structural Heart Disease ◽  
Left Ventricular ◽  
Gadolinium Enhancement ◽  
Myocardial Mechanics ◽  
Systemic Sarcoidosis ◽  
Lv Ejection Fraction

Objective: To assess myocardial mechanics by cardiac magnetic resonance (CMR)-derived strain in patients with biopsy-proven systemic sarcoidosis. Methods: We included 50 consecutive patients (age 51 ± 11 years old, 30 males) with biopsy-proven systemic sarcoidosis who underwent gadolinium-enhanced CMR for suspected cardiac sarcoid involvement. Late gadolinium enhancement (LGE) was considered positive if showing an intramyocardial/subepicardial location with a nonischemic pattern. From cine images and using dedicated software (TomTec©), we quantified mean left ventricular (LV) longitudinal, radial, and circumferential peak strains as the average of 16 standard myocardial segments. We also randomly selected from our database 15 control subjects without structural heart disease (age 41 ± 11 years old, 5 males). Results: Both mean longitudinal strain (LS) and LV ejection fraction (LVEF) were lower in sarcoid patients than controls (-11.8 ± 7.3% vs. -18.1 ± 3.9%, p55%, n=32) mean LS was reduced compared to controls (-12.2 ± 7.8% vs. -18.1 ± 3.9% respectively, p=0.01; Fig 1B). There was no correlation between LVEF and mean LS (r=-0.11, p=0.65). We found no significant differences in circumferential or radial strains. LGE was present in 16 patients (32%). Sarcoid patients with LGE showed significantly less mean LS than those without (-8.5 ± 8.4% vs. -13.6 ± 6.4%, p<0.001; Fig 1A) although LVEF did not differ significantly (52% vs. 59%, p=0.35). No significant differences in circumferential or radial strains were found. Conclusions: In patients with systemic sarcoidosis, evaluation of cardiac mechanics with CMR detects myocardial dysfunction even in the presence of preserved LVEF. This is more pronounced in patients with positive LGE. The potential diagnostic and prognostic significance of CMR-derived myocardial strain in sarcoidosis deserves further investigation.

scholarly journals Cardiac mechanics as predictors of left ventricular reverse remodelling in patients with dilated non-ischemic cardiomyopathy

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
M Ferrandez ◽  
F Islas ◽  
A Travieso ◽  
J Diz-Diaz ◽  
A Restrepo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ischemic Cardiomyopathy ◽  
Multimodality Imaging ◽  
Global Longitudinal Strain ◽  
Cardiac Mechanics ◽  
Left Ventricular ◽  
Cardiac Resynchronization ◽  
Imaging Parameters ◽  
Reverse Remodelling

Abstract Background and purpose The appearance of left ventricular reverse remodelling (LVRR) is associated with a better prognosis in patients with dilated non-ischemic cardiomyopathy (DCM). Our aim was to identify cardiac imaging parameters, including speckle tracking by transthoracic echocardiography (TTE) and feature tracking by CMR, associated with LVRR in a prospective cohort of patients with DCM. Methods From 2014 to 2021, 182 patients with DCM and left ventricle ejection fraction (LVEF) &lt;40% were prospectively evaluated in our hospital. LVRR was defined as an increase in LVEF ≥10 points or absolute LVEF ≥50%, associated with a reduction in left ventricular end- diastolic diameter ≥10%. Patients underwent multimodality imaging evaluation including CMR with a 1.5 Tesla scanner, and TTE. Cardiac mechanics, including global longitudinal strain (GLS), strain rate (SR) and mechanical dispersion (MD) were measured. Results Median age of our cohort was 62.3 (14.4) years, and 67.7% were male. Most patients (&gt;90%) were treated with beta-blockers or RASS blockers, and 67% with mineralocorticoid receptor antagonists. 30% had cardiac resynchronization therapy (CRT) and 37% had ICD as primary prevention. Mean LVEF was 31.3%. During a mean follow-up period of 35.9 (35.4) months, 38.3% of patients had LVRR. Age and gender distribution were similar in both groups. Regarding cardiovascular risk factors and pharmacological treatment, no differences were found between patients with and without LVRR. Baseline CRT therapy was not associated with LVRR (22.6% vs 34.7%; p=0.249). However, there was a trend towards higher LVRR in those who received CRT during follow-up 18.8% vs 0%; p=0.069). Patients who experienced LVRR had lower basal LVEF (23.4% vs 29%; p&lt;0.008), as well as poorer RV function, including lower RVEF (40.5% vs 51%; p=0.006) and lower TAPSE (16 mm vs 19 mm; p=0.021). Regarding cardiac mechanics, those patients with lower GLS (−9% vs −12%; p=0.001), and higher MD (73 mm vs 55 mm; p=0,050) had LVRR more frequently during follow-up. The presence of a left bundle branch block (LBBB) contraction pattern by strain was associated with higher rate of LVRR (83.3% vs 30.4%; p=0.011). The burden of fibrosis measured by LGE with CMR was not associated with LVRR (14% vs 12%; p=NS). Patients with LVRR had a lower cardiovascular mortality (3.3 vs 14.3%; p=0.117), lower mortality due to heart failure (0% vs 12.2%; p=0.046), less heart failure hospitalizations (20% vs 46.9%; p=0.016), and a lower incidence of ventricular tachyarrhythmias (3.3% vs 18.4%; p=0.051). Conclusions LVRR in patients with DCM receiving optimized medical therapy is associated with a better prognosis. Imaging parameters, including a lower basal LVEF, RVEF, GLS and higher MD, as well as LBBB echo pattern, were associated with a higher frequency of LVRR, and might help to identify patients who could benefit from CRT/and may be helpful to stratify patients's risk. FUNDunding Acknowledgement Type of funding sources: None.

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