scholarly journals Functional Recovery of Anterior Semicircular Canal Afferents following Hair Cell Regeneration in Birds

2002 ◽  
Vol 3 (2) ◽  
pp. 149-166 ◽  
Author(s):  
Richard Boyle ◽  
Stephen M. Highstein ◽  
John P. Carey ◽  
Jinping Xu
Keyword(s):  
Hair Cell ◽  
Functional Recovery ◽  
Semicircular Canal ◽  
Cell Regeneration ◽  
Hair Cell Regeneration ◽  
Anterior Semicircular Canal ◽  
Semicircular Canal Afferents

scholarly journals Suppression of Inflammation Delays Hair Cell Regeneration and Functional Recovery Following Lateral Line Damage in Zebrafish Larvae

2020 ◽  
Author(s):  
Ru Zhang ◽  
Xiao-Peng Liu ◽  
Ya-Juan Li ◽  
Ming Wang ◽  
Lin Chen ◽  
...  
Keyword(s):  
Hair Cell ◽  
Functional Recovery ◽  
Lateral Line ◽  
Hair Cells ◽  
Calcium Imaging ◽  
Inflammatory Responses ◽  
Early Stage ◽  
Cell Regeneration ◽  
Hair Cell Regeneration ◽  
Cochlear Hair Cells

AbstractBackgroundHuman cochlear hair cells cannot spontaneously regenerate after loss. In contrast, those in fish and amphibians have a remarkable ability to regenerate after damaged. Previous studies focus on signaling mechanisms of hair cell regeneration, such as Wnt and Notch signals but seldom on the fact that the beginning of regeneration is accompanied by a large number of inflammatory responses. The detailed role of this inflammation in hair cell regeneration is still unknown. In addition, there is no appropriate behavioral method to quantitatively evaluate the functional recovery of lateral line hair cells after regeneration.ResultsIn this study, we found that when inflammation was suppressed, the regeneration of lateral line hair cells and the recovery of the rheotaxis of the larvae were significantly delayed. Calcium imaging showed that the function of the neuromasts in the inflammation-inhibited group was weaker than that in the non-inflammation-inhibited group at the Early Stage of regeneration, and returned to normal at the Late Stage. Calcium imaging also revealed the cause of the mismatch between the function and quantity during regeneration.ConclusionsOur results, meanwhile, suggest that suppressing inflammation delays hair cell regeneration and functional recovery when hair cells are damaged. This study may provide a new knowledge for how to promote hair cell regeneration and functional recovery in adult mammals.

scholarly journals Suppression of Inflammation Delays Hair Cell Regeneration and Functional Recovery Following Lateral Line Damage in Zebrafish Larvae

Biomolecules ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1451
Author(s):  
Ru Zhang ◽  
Xiaopeng Liu ◽  
Yajuan Li ◽  
Ming Wang ◽  
Lin Chen ◽  
...  
Keyword(s):  
Hair Cell ◽  
Functional Recovery ◽  
Lateral Line ◽  
Hair Cells ◽  
Calcium Imaging ◽  
Inflammatory Factors ◽  
Cell Regeneration ◽  
Human Beings ◽  
Hair Cell Regeneration ◽  
Zebrafish Larvae

Cochlear hair cells in human beings cannot regenerate after loss; however, those in fish and other lower species can. Recently, the role of inflammation in hair cell regeneration has been attracting the attention of scientists. In the present study, we investigated how suppression of inflammatory factors affects hair cell regeneration and the functional recovery of regenerated hair cells in zebrafish. We killed hair cells in the lateral line of zebrafish larvae with CuSO4 to induce an inflammatory response and coapplied BRS-28, an anti-inflammatory agent to suppress the inflammation. The recovery of the hair cell number and rheotaxis was slower when CuSO4 and BRS-28 were coapplied than when CuSO4 was applied alone. The recovery of hair cell count lagged behind that of the calcium imaging signal during the regeneration. The calcium imaging signal in the neuromasts in the inflammation-inhibited group was weaker than that in the noninflammation-inhibited group at the early stage of regeneration, although it returned to normal at the late stage. Our study demonstrates that suppressing inflammation by BRS-28 delays hair cell regeneration and functional recovery when hair cells are damaged. We suspect that BRS-28 inhibits pro-inflammatory factors and thereby reduces the migration of macrophages to delay the regeneration of hair cells.

Hair cell regeneration in the inner ear

1994 ◽  
Vol 111 (3) ◽  
pp. 281-301 ◽  
Author(s):  
T TSUE ◽  
E OESTERLE ◽  
E RUBEL
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Cell Regeneration ◽  
Hair Cell Regeneration
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