scholarly journals Changes in the Three-Dimensional Angular Vestibulo-Ocular Reflex following Intratympanic Gentamicin for Ménière's Disease

2002 ◽  
Vol 3 (4) ◽  
pp. 430-443 ◽  
Author(s):  
John P. Carey ◽  
Lloyd B. Minor ◽  
Grace C.Y. Peng ◽  
Charles C. Della Santina ◽  
Phillip D. Cremer ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Ocular Reflex ◽  
Intratympanic Gentamicin ◽  
Vestibulo Ocular Reflex ◽  
Ménière's Disease

Application of multivariate statistics to vestibular testing: Discriminating between Menière's disease and migraine associated dizziness

2001 ◽  
Vol 11 (1) ◽  
pp. 53-65 ◽  
Author(s):  
P.S. Dimitri ◽  
C. Wall ◽  
J.G. Oas ◽  
S.D. Rauch
Keyword(s):  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Classification Rate ◽  
Ocular Reflex ◽  
Vestibular Testing ◽  
Vestibulo Ocular Reflex ◽  
Ménière's Disease

Menière's disease (MD) and migraine associated dizziness (MAD) are two disorders that can have similar symptomatologies, but differ vastly in treatment. Vestibular testing is sometimes used to help differentiate between these disorders, but the inefficiency of a human interpreter analyzing a multitude of variables independently decreases its utility. Our hypothesis was that we could objectively discriminate between patients with MD and those with MAD using select variables from the vestibular test battery. Sinusoidal harmonic acceleration test variables were reduced to three vestibulo-ocular reflex physiologic parameters: gain, time constant, and asymmetry. A combination of these parameters plus a measurement of reduced vestibular response from caloric testing allowed us to achieve a joint classification rate of 91%, independent quadratic classification algorithm. Data from posturography were not useful for this type of differentiation. Overall, our classification function can be used as an unbiased assistant to discriminate between MD and MAD and gave us insight into the pathophysiologic differences between the two disorders.

Autorotation Test of the Horizontal Vestibulo-Ocular Reflex in Meniere's Disease

1993 ◽  
Vol 109 (3) ◽  
pp. 399-412 ◽  
Author(s):  
Matthew Ng ◽  
Linda L. Davis ◽  
Dennis P. O'Leary
Keyword(s):  
High Frequency ◽  
Meniere’S Disease ◽  
Head Movements ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Ocular Reflex ◽  
Vestibulo Ocular Reflex ◽  
Ménière's Disease

Sixty-four patients with the diagnosis of Meniere's disease were tested at the House Ear Clinic with an active head-rotation test system, the Vestibular Autorotation Test (VAT). The VAT is a portable, computerized test that measures the horizontal vestibulo-ocular reflex (VOR) with the use of high-frequency (2 to 6 Hz) active head movements to obtain gain and phase. The purpose of this study was to characterize the horizontal VOR at high frequencies in patients with Meniere's disease. At frequencies from 5 to 6 Hz, all patients demonstrated horizontal phase greater than 180 degrees and 85% showed abnormal VAT results. The most common patterns were decreased gain or increased phase values, or both, relative to normative data. No significant differences in the degree of abnormality in gain and phase were noted among groups of patients when the patients were clinically staged. We conclude that, in our test population of patients with Meniere's disease, the VAT shows common gain and phase patterns and abnormalities of the horizontal VOR. This may contribute to high retinal image velocities, which render the patient unable to stabilize retinal images during locomotion (visual field image slip), in as many as 85% of the patients tested, regardless of clinical stage. Such high-frequency testing can reveal abnormalities of the horizontal VOR not apparent from conventional vestibular testing. Thus VAT provides additional information about the functioning VOR when combined with the present vestibular test battery. (OTOLARYNGOL HEAD NECK SURG 1993;109:399–412.)

scholarly journals Angular Vestibulo-Ocular Reflex Gains Correlate with Vertigo Control after Intratympanic Gentamicin Treatment for Meniere's Disease

2005 ◽  
Vol 114 (10) ◽  
pp. 777-785 ◽  
Author(s):  
Frank R. Lin ◽  
Americo A. Migliaccio ◽  
Thomas Haslwanter ◽  
Lloyd B. Minor ◽  
John P. Carey
Keyword(s):  
Treatment Group ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Horizontal Canal ◽  
Intratympanic Gentamicin ◽  
Vestibulo Ocular Reflex ◽  
Ménière's Disease

Objectives: The objective of our study was to determine whether angular vestibulo-ocular reflex (aVOR) gains correlated with vertigo control after intratympanic gentamicin treatment for Meniere's disease. Methods: We conducted a prospective study of 18 subjects with unilateral Meniere's disease treated with intratympanic gentamicin injection and followed all subjects for 1 year. We measured the gain of the aVOR elicited by rapid rotary head thrusts in each of the canal planes for each subject before and after treatment with intratympanic gentamicin by using magnetic search coils to record eye movements. Results: During the follow-up period, 11 subjects (“single-treatment group”; 61%) had control of their vertigo with a single gentamicin injection. The remaining 7 subjects (“multiple-treatment group”; 39%) experienced recurrent vertigo that required a second injection of gentamicin at a mean of 6 months after the first treatment. The 11 subjects in the single-treatment group had significantly greater reduction of labyrinthine function after the first treatment, as measured by change in ipsilateral horizontal canal gain, than did the 7 subjects with vertigo recurrence. Changes in caloric asymmetry did not correlate with vertigo control. Conclusions: Our results suggest that successful treatment of Meniere's disease is closely related to attenuation of semicircular canal function as measured by horizontal canal aVOR gains.

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