Epithelial sodium channels expressed in Xenopus oocytes are activated by cyclic-AMP

2002 ◽  
Vol 6 (4) ◽  
pp. 195-201 ◽  
Author(s):  
K. Tamba ◽  
Y. S. Oh ◽  
J. K. Tucker ◽  
M. W. Quick ◽  
D. G. Warnock
Keyword(s):  
Cyclic Amp ◽  
Sodium Channels ◽  
Xenopus Oocytes ◽  
Epithelial Sodium Channels

Intrinsic gating mechanisms of epithelial sodium channels

2002 ◽  
Vol 283 (2) ◽  
pp. C646-C650 ◽  
Author(s):  
Hong-Long Ji ◽  
Catherine M. Fuller ◽  
Dale J. Benos
Keyword(s):  
Sodium Channels ◽  
Xenopus Oocytes ◽  
Transmembrane Domain ◽  
Receptor Site ◽  
Epithelial Sodium Channels ◽  
Gating Mechanisms ◽  
Putative Receptor ◽  
Arginine Residues ◽  
Insight Into ◽  
Positively Charged

The hypothesis that there is a highly conserved, positively charged region distal to the second transmembrane domain in α-ENaC (epithelial sodium channel) that acts as a putative receptor site for the negatively charged COOH-terminal β- and γ-ENaC tails was tested in mutagenesis experiments. After expression in Xenopus oocytes, α-ENaC constructs in which positively charged arginine residues were converted into negatively charged glutamic acids could not be inhibited by blocking peptides. These observations provide insight into the gating machinery of ENaC.

Medullary epithelial sodium channels (ENAC) participate in cerebral blood flow (CBF) autoregulation

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S190-S190
Author(s):  
Eugene Golanov ◽  
Heather Drummond ◽  
Jasleen Shant ◽  
Benjamin Clower ◽  
Betty Chen
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Sodium Channels ◽  
Epithelial Sodium Channels

scholarly journals The Plant-Derived Glucocorticoid Receptor Agonist Endiandrin A Acts as Co-Stimulator of Colonic Epithelial Sodium Channels (ENaC) via SGK-1 and MAPKs

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49426 ◽  
Author(s):  
Dana Kuntzsch ◽  
Theresa Bergann ◽  
Petra Dames ◽  
Anja Fromm ◽  
Michael Fromm ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Sodium Channels ◽  
Receptor Agonist ◽  
Epithelial Sodium Channels

scholarly journals Proteolytic Regulation of Epithelial Sodium Channels by Urokinase Plasminogen Activator

2015 ◽  
Vol 290 (9) ◽  
pp. 5241-5255 ◽  
Author(s):  
Hong-Long Ji ◽  
Runzhen Zhao ◽  
Andrey A. Komissarov ◽  
Yongchang Chang ◽  
Yongfeng Liu ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Sodium Channels ◽  
Urokinase Plasminogen Activator ◽  
Epithelial Sodium Channels

scholarly journals Ethanol Alters Alveolar Fluid Balance via Nadph Oxidase (NOX) Signaling to Epithelial Sodium Channels (ENaC) in the Lung

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e54750 ◽  
Author(s):  
Charles A. Downs ◽  
David Q. Trac ◽  
Lisa H. Kreiner ◽  
Amity F. Eaton ◽  
Nicholle M. Johnson ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Sodium Channels ◽  
Fluid Balance ◽  
Epithelial Sodium Channels

scholarly journals Epithelial Sodium Channels in Pulmonary Epithelial Progenitor and Stem Cells

2016 ◽  
Vol 12 (9) ◽  
pp. 1150-1154 ◽  
Author(s):  
Yang Liu ◽  
Bi-Jie Jiang ◽  
Run-Zhen Zhao ◽  
Hong-Long Ji
Keyword(s):  
Stem Cells ◽  
Sodium Channels ◽  
Epithelial Sodium Channels

Up-regulation of functional voltage-dependent sodium channels by cyclic AMP-dependent protein kinase in adrenal medulla

1996 ◽  
Vol 709 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Tomoaki Yuhi ◽  
Akihiko Wada ◽  
Ryuichi Yamamoto ◽  
Toshihiko Yanagita ◽  
Hiromi Niina ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Sodium Channels ◽  
Adrenal Medulla ◽  
Dependent Protein Kinase ◽  
Voltage Dependent ◽  
Dependent Protein

MicroO-conotoxin MrVIA inhibits mammalian sodium channels, but not through site I

1996 ◽  
Vol 76 (3) ◽  
pp. 1423-1429 ◽  
Author(s):  
H. Terlau ◽  
M. Stocker ◽  
K. J. Shon ◽  
J. M. McIntosh ◽  
B. M. Olivera
Keyword(s):  
Rat Brain ◽  
Sodium Channels ◽  
Xenopus Oocytes ◽  
Electric Organ ◽  
Hill Coefficient ◽  
Inactivation Kinetics ◽  
Type Ii ◽  
Amino Acid Peptide ◽  
Voltage Gated Sodium Channels ◽  
Dependent Inhibition

1. A 31-amino-acid peptide from the venom of the snail-hunting species Conus marmoreus, microO-conotoxin MrVIA, inhibits mammalian voltage-gated sodium channels through a novel mechanism distinct from saxitoxin, tetrodotoxin, or mu-conotoxin. 2. MicroO-Conotoxin MrVIA blocks rat brain type II sodium channels expressed in Xenopus oocytes (IC50 approximately 200 nM, Hill coefficient approximately 1.6 +/- 0.2, mean +/- SE). Channel activation/inactivation kinetics and current-voltage relationships were unperturbed. 3. MicroO-Conotoxin MrVIA does not cause phasic or use-dependent inhibition of sodium currents measured in Xenopus oocytes expressing rat brain type II sodium channels, but shifts the steady-state availability of these sodium channels to more hyperpolarized potentials. 4. MicroO-Conotoxin MrVIA inhibited rapidly inactivating sodium channel conductance in rat hippocampal cells in culture. The inhibition was rapidly reversible. 5. MicroO-Conotoxin MrVIA does not displace specific [3H]saxitoxin binding to either rat brain or Electrophorus electric organ sites, indicating inhibitory effects mediated through a binding site distinct from site I.

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