Clinicopathological features of antineutrophil cytoplasmic antibodies-associated vasculitis in Japanese patients with IgA nephropathy

2000 ◽  
Vol 4 (3) ◽  
pp. 251-256 ◽  
Author(s):  
M. Shimizu ◽  
T. Wada ◽  
N. Sakai ◽  
Y. Izumiya ◽  
K. Furuichi ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Japanese Patients ◽  
Clinicopathological Features ◽  
Antineutrophil Cytoplasmic Antibodies

scholarly journals Clinicopathological features in the Japanese patients with IgA nephropathy.

1983 ◽  
Vol 22 (3) ◽  
pp. 219-222 ◽  
Author(s):  
Takeyuki KITAJIMA ◽  
Mutsumi MURAKAMI ◽  
Osamu SAKAI
Keyword(s):  
Iga Nephropathy ◽  
Japanese Patients ◽  
Clinicopathological Features

IgA Nephropathy in Japanese Children and Adults: A Comparative Study of Clinicopathological Features

1990 ◽  
Vol 10 (3) ◽  
pp. 191-197 ◽  
Author(s):  
Kaname Okada ◽  
Mamoru Funai ◽  
Koichiro Kawakami ◽  
Shoji Kagami ◽  
Ichiro Yano ◽  
...  
Keyword(s):  
Comparative Study ◽  
Iga Nephropathy ◽  
Clinicopathological Features ◽  
Japanese Children

Clinicopathological features of microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) in Japanese patients.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 629-629
Author(s):  
Akihito Kawazoe ◽  
Kohei Shitara ◽  
Masaaki Noguchi ◽  
Shota Fukuoka ◽  
Yasutoshi Kuboki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Trials ◽  
Microsatellite Instability ◽  
Metastatic Colorectal Cancer ◽  
Phase Ii ◽  
Large Scale ◽  
Phase Ii Trial ◽  
Japanese Patients ◽  
Clinicopathological Features ◽  
Braf V600e

629 Background: Recently, anti-programmed death 1 (PD-1) antibody has shown promising efficacy in a phase II trial for patients with microsatellite instability-high (MSI-H) tumors, especially in those with metastatic colorectal cancer (mCRC). Currently, several clinical trials of anti-PD-1 antibody for patients with MSI-H mCRC are ongoing. However, little is known about the frequencies and clinicopathological features of MSI-H mCRC in Japanese patients. Methods: Patients with histologically confirmed adenocarcinoma of mCRC were eligible for this observational study. MSI status was analyzed in tumors using the MSI Analysis System (Promega) composed of 5 mononucleotide markers. KRAS, NRAS, BRAF and PIK3CA mutations were also evaluated using the multiplex kit. Results: A total of 232 patients were enrolled until August 31, 2015, of which MSI-H was detected in 5 patients (2.1%). Among five patients with MSI-H mCRC, median age was 45 years (28-75), four had tumors on right-sided colon, five had moderately differentiated adenocarcinoma, one had poorly differentiated adenocarcinoma, and three had stage IV disease at presentation. Overall survival for patients with MSI-H mCRC from the start of first-line systemic chemotherapy ranged from 8.1 to 62.0 month. All five patients with MSI-H mCRC had RAS wild-type tumors and two had BRAF V600E mutation. One patient with MSI-H mCRC was enrolled in a phase II trial of anti-PD-1 antibody. Conclusions: MSI-H mCRC is rare in Japanese patients. A large scale nationwide cancer genome screening project together with MSI status is required to evaluate more detailed clinicopathological features and facilitate the enrollment of patients with MSI-H mCRC for clinical trials with anti-PD-1 antibody.

Comprehensive evaluation of the significance of immunofluorescent findings on clinicopathological features in IgA nephropathy

2018 ◽  
Vol 23 (2) ◽  
pp. 169-181 ◽  
Author(s):  
Ritsuko Katafuchi ◽  
Hiroshi Nagae ◽  
Kosuke Masutani ◽  
Kazuhiko Tsuruya ◽  
Koji Mitsuiki
Keyword(s):  
Iga Nephropathy ◽  
Comprehensive Evaluation ◽  
Clinicopathological Features

scholarly journals Discordant clinicopathological features in monozygotic twins with IgA nephropathy

2011 ◽  
Vol 26 (12) ◽  
pp. 4146-4148 ◽  
Author(s):  
N. Tsuboi ◽  
T. Kawamura ◽  
H. Okonogi ◽  
T. Ishii ◽  
Y. Utsunomiya ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Monozygotic Twins ◽  
Clinicopathological Features
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