Insulin-like growth factor I stimulates glucose uptake and expression of glucose transporter 1 in cultured mesangial cells

1999 ◽  
Vol 3 (3) ◽  
pp. 159-162
Author(s):  
Masaki Togawa ◽  
M. Haneda ◽  
Daisuke Koya ◽  
Ken Inoki ◽  
Toshiro Sugimoto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Glucose Uptake ◽  
Glucose Transporter ◽  
Mesangial Cells ◽  
Insulin Like Growth Factor ◽  
Glucose Transporter 1 ◽  
Factor I ◽  
Growth Factor I

scholarly journals INSULIN GROWTH FACTOR I AND ITS RECEPTOR ARE ANTAGONISTIC MODULATORS OF GLUCOSE HANDLING BY ASTROCYTES

2015 ◽  
Author(s):  
Edwin Hernandez ◽  
Ana M Fernandez ◽  
Alberto Perez Alvarez ◽  
Sara Mederos ◽  
Paloma Perez Domper ◽  
...  
Keyword(s):  
Growth Factor ◽  
Glucose Uptake ◽  
Glucose Transporter ◽  
Brain Slices ◽  
Glucose Transporter 1 ◽  
Factor I ◽  
Igf I ◽  
Pharmacological Blockade ◽  
Growth Factor I

Reducing insulin-like growth factor I receptor (IGF-IR) levels or administration of IGF-I show beneficial effects in the brain. We now provide evidence to help resolve this paradox. The unliganded IGF-IR inhibits glucose uptake by astrocytes while its stimulation with IGF-I, in concert with insulin activation of the insulin receptor, produces the opposite effect. In vivo imaging showed that shRNA interference of brain IGF-IR increased glucose uptake by astrocytes while pharmacological blockade of IGF-IR reduced it. Brain 18FGlucose-PET of IGF-IR shRNA injected mice confirmed an inhibitory role of unliganded IGF-IR on glucose uptake, whereas glucose-dependent recovery of neuronal activity in brain slices was blunted by pharmacological blockade of IGF-IR. Mechanistically, we found that the unliganded IGF-IR retains glucose transporter 1 (GLUT1), the main glucose transporter in astrocytes, inside the cell while IGF-I, in cooperation with insulin, synergistically stimulates MAPK/PKD to promote association of IGF-IR with GLUT 1 via Rac1/GIPC1 and increases GLUT1 availability at the cell membrane. These findings identify IGF-I and its receptor as antagonistic modulators of brain glucose uptake.

Mesangial cells from diabetic NOD mice constitutively secrete increased amounts of insulin-like growth factor-I.

Endocrinology ◽  
1993 ◽  
Vol 133 (4) ◽  
pp. 1783-1788 ◽  
Author(s):  
S J Elliot ◽  
L J Striker ◽  
M Hattori ◽  
C W Yang ◽  
C J He ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mesangial Cells ◽  
Nod Mice ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals Regulation of insulin-like growth factor I receptors in diabetic mesangial cells

1991 ◽  
Vol 266 (4) ◽  
pp. 2369-2373 ◽  
Author(s):  
B S Oemar ◽  
H G Foellmer ◽  
L Hodgdon-Anandant ◽  
S A Rosenzweig
Keyword(s):  
Growth Factor ◽  
Mesangial Cells ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Studies on Binding and Mitogenic Effect of Insulin and Insulin-Like Growth Factor I in Glomerular Mesangial Cells*

Endocrinology ◽  
1988 ◽  
Vol 122 (6) ◽  
pp. 2788-2795 ◽  
Author(s):  
FRANCESCO G. CONTI ◽  
LILIANE J. STRIKER ◽  
MAXINE A. LESNIAK ◽  
KAREN MACKAY ◽  
JESSE ROTH ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mesangial Cells ◽  
Insulin Like Growth Factor ◽  
Glomerular Mesangial Cells ◽  
Mitogenic Effect ◽  
Factor I ◽  
Growth Factor I

scholarly journals Regulation of Human Trophoblast GLUT1 Glucose Transporter by Insulin-Like Growth Factor I (IGF-I)

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e106037 ◽  
Author(s):  
Marc U. Baumann ◽  
Henning Schneider ◽  
Antoine Malek ◽  
Vidya Palta ◽  
Daniel V. Surbek ◽  
...  
Keyword(s):  
Growth Factor ◽  
Glucose Transporter ◽  
Insulin Like Growth Factor ◽  
Human Trophoblast ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I ◽  
Glut1 Glucose Transporter

Insulin-like growth factor I (IGF-I) stimulates glucose and amino acid uptake in cultured glomerular mesangial cells

1991 ◽  
Vol 5 (2-3) ◽  
pp. 184-185 ◽  
Author(s):  
Masaki Togawa ◽  
Ryuichi Kikkawa ◽  
Masakazu Haneda ◽  
Daisuke Koya ◽  
Naoki Horide ◽  
...  
Keyword(s):  
Amino Acid ◽  
Growth Factor ◽  
Mesangial Cells ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Insulin Like Growth Factor ◽  
Glomerular Mesangial Cells ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I
Sign in / Sign up

Export Citation Format

Share Document