Strain-Specific Differences in the Amount of Shiga Toxin Released from Enterohemorrhagic Escherichia coli O157 following Exposure to Subinhibitory Concentrations of Antimicrobial Agents

1998 ◽  
Vol 17 (11) ◽  
pp. 761-766 ◽  
Author(s):  
K. Grif ◽  
M. P. Dierich ◽  
H. Karch ◽  
F. Allerberger
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Antimicrobial Agents ◽  
Enterohemorrhagic Escherichia Coli ◽  
Escherichia Coli O157 ◽  
Subinhibitory Concentrations

Effect of subinhibitory concentrations of antimicrobial agents (quinolones and macrolide) on the production of verotoxin by enterohemorrhagic Escherichia coli O157:H7

1999 ◽  
Vol 45 (9) ◽  
pp. 732-739 ◽  
Author(s):  
M Yoh ◽  
E K Frimpong ◽  
S P Voravuthikunchai ◽  
T Honda
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Agent ◽  
Antimicrobial Agents ◽  
Enterohemorrhagic Escherichia Coli ◽  
Escherichia Coli O157 ◽  
Ministry Of Health ◽  
Wide Range ◽  
Subinhibitory Concentrations

In Japan, antimicrobial agent therapy for patients with diarrhea due to enterovirulent organisms including enterohemorrhagic Escherichia coli (EHEC) is common, and norfloxacin (NFLX), fosfomycin, and kanamycin are recommended for EHEC treatment by the Japanese Ministry of Health and Welfare. The aim of this study was to analyze the effects of antimicrobial agents which have been used or recommended for the treatment of EHEC on the production of verotoxin (VT) in vitro. Subinhibitory concentrations of quinolones, NFLX, sparofloxacin (SPFX), and grepafloxacin (GPFX) markedly stimulated the productions of VT1 and VT2. The macrolide azithromycin (AZM), erythromycin (EM), and clarithromycin (CAM) did not stimulate the production of VT at a wide range of concentrations. These in vitro results indicate that when quinolones are prescribed for a patient infected with EHEC, the concentration of antimicrobial agents used in vivo and the susceptibility of the EHEC strains against quinolones should be taken into consideration.Key words: EHEC, O157:H7, verotoxin, quinolone, macrolide.

scholarly journals The Shiga toxin 2 production level in enterohemorrhagic Escherichia coli O157:H7 is correlated with the subtypes of toxin-encoding phage

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Yoshitoshi Ogura ◽  
Shakhinur Islam Mondal ◽  
Md Rakibul Islam ◽  
Toshihiro Mako ◽  
Kokichi Arisawa ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Enterohemorrhagic Escherichia Coli ◽  
Production Level ◽  
Escherichia Coli O157 ◽  
Shiga Toxin 2

scholarly journals Dam Methyltransferase Is Required for Stable Lysogeny of the Shiga Toxin (Stx2)-Encoding Bacteriophage 933W of Enterohemorrhagic Escherichia coli O157:H7

2007 ◽  
Vol 190 (1) ◽  
pp. 438-441 ◽  
Author(s):  
Kenan C. Murphy ◽  
Jennifer M. Ritchie ◽  
Matthew K. Waldor ◽  
Anders Løbner-Olesen ◽  
M. G. Marinus
Keyword(s):  
Escherichia Coli ◽  
Virulence Factors ◽  
Shiga Toxin ◽  
Enterohemorrhagic Escherichia Coli ◽  
Escherichia Coli O157 ◽  
Prophage Induction ◽  
Shiga Toxin 2 ◽  
Low Threshold

ABSTRACT Shiga toxin 2 (Stx2), one of the principal virulence factors of enterohemorrhagic Escherichia coli, is encoded by 933W, a lambda-like prophage. 933W prophage induction contributes to Stx2 production, and here, we provide evidence that Dam methyltransferase is essential for maintenance of 933W lysogeny. Our findings are consistent with the idea that the 933W prophage has a relatively low threshold for induction, which may promote Stx2 production during infection.

Sign in / Sign up

Export Citation Format

Share Document