Antibiotic Susceptibilities Among Recent Clinical Isolates of Haemophilus influenzae and Moraxella catarrhalis from Fifteen Countries

2001 ◽  
Vol 20 (1) ◽  
pp. 0055-0060 ◽  
Author(s):  
S. I. Bandak ◽  
M. R. Turnak ◽  
B. S. Allen ◽  
L. D. Bolzon ◽  
D. A. Preston ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Moraxella Catarrhalis ◽  
Clinical Isolates ◽  
Antibiotic Susceptibilities

scholarly journals Determination of antimicrobial action of "Apicold oral spray"

2021 ◽  
pp. 66-70
Author(s):  
Anatoly L. Kosakovsky ◽  
Oksana M. Golovnya ◽  
Svitlana G. Gunko ◽  
Ilona A. Kosakivska
Keyword(s):  
Staphylococcus Aureus ◽  
Candida Albicans ◽  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Streptococcus Pyogenes ◽  
Moraxella Catarrhalis ◽  
Antimicrobial Effect ◽  
Antimicrobial Action ◽  
Clinical Isolates ◽  
Fungicidal Action

Introduction: The causative agents of acute tonsillopharyngitis are viruses and bacterial flora. Treatment of acute pharyngitis is mainly local, which includes aerosols with antiseptics. Aim: Study of antimicrobial action of "Apicold oral spray" on clinical isolates of microorganisms Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis and Candida albicans isolated from patients' oropharynx in patients. Material and methods: The effect of Apicold Oral Spray (manufactured by APIPHARMA doo) on clinical isolates of Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis, and Candida albicans in Ukrainian patients was studied. Antimicrobial activity was assessed after 5, 10 and 20 minutes of action of one dose of "Apicold oral spray" on microorganisms. Bactericidal and fungicidal action (inhibition of cell growth of microorganisms) is expressed as a percentage according to the control. Results and discussion: Apicold Oral Spray has a 100% antimicrobial effect after 5 minutes on clinical isolates of Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis and Candida albicans (complete growth inhibition of all 5 clinical isolates after 20 minutes). Conclusion: "Apicold oral spray" has a high antimicrobial effect on clinical isolates of Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis and Candida albicans, which is confirmed by 100% inhibition of the growth of all bacteria after 5 minutes

scholarly journals Activities of Ceftobiprole, a Novel Broad-Spectrum Cephalosporin, against Haemophilus influenzae and Moraxella catarrhalis

2006 ◽  
Vol 50 (6) ◽  
pp. 2050-2057 ◽  
Author(s):  
Tatiana Bogdanovich ◽  
Catherine Clark ◽  
Lois Ednie ◽  
Gengrong Lin ◽  
Kathy Smith ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Broad Spectrum ◽  
Moraxella Catarrhalis ◽  
Clinical Isolates ◽  
Phase Iii ◽  
Phase Iii Clinical Trials ◽  
Highly Active ◽  
Amoxicillin Clavulanate ◽  
Resistant Strains ◽  
Time Kill

ABSTRACT Ceftobiprole, a broad-spectrum pyrrolidinone-3-ylidenemethyl cephem currently in phase III clinical trials, had MICs between 0.008 μg/ml and 8.0 μg/ml for 321 clinical isolates of Haemophilus influenzae and between ≤0.004 μg/ml and 1.0 μg/ml for 49 clinical isolates of Moraxella catarrhalis. Ceftobiprole MIC50 and MIC90 values for H. influenzae were 0.06 μg/ml and 0.25 μg/ml for β-lactamase-positive strains (n = 262), 0.03 μg/ml and 0.25 μg/ml for β-lactamase-negative strains (n = 40), and 0.5 μg/ml and 2.0 μg/ml for β-lactamase-negative ampicillin-resistant strains (n = 19), respectively. Ceftobiprole MIC50 and MIC90 values for β-lactamase-positive M. catarrhalis strains (n = 40) were 0.12 μg/ml and 0.5 μg/ml, respectively, whereas the ceftobiprole MIC range for β-lactamase-negative M. catarrhalis strains (n = 9) was ≤0.004 to 0.03 μg/ml. Ceftriaxone MICs usually were generally at least twofold lower than those of ceftobiprole, whereas amoxicillin-clavulanate MICs usually were higher than those of ceftobiprole. Azithromycin and telithromycin had unimodal MIC distributions against H. influenzae, with MIC90 values of azithromycin and telithromycin of 2 μg/ml and 4 μg/ml, respectively. Except for selected quinolone-nonsusceptible H. influenzae strains, moxifloxacin proved highly active, with MIC90 values of 0.12 μg/ml. Time-kill analyses showed that ceftobiprole, ceftriaxone, cefpodoxime, amoxicillin-clavulanate, azithromycin, telithromycin, and moxifloxacin were bactericidal at 2× MIC by 24 h against all 10 H. influenzae strains surveyed. Only modest increases in MICs were found for H. influenzae or M. catarrhalis clones after 50 serial passages in the presence of subinhibitory concentrations of ceftobiprole, and single-passage selection showed that the selection frequency of H. influenzae or M. catarrhalis clones with elevated ceftobiprole MICs is quite low.

scholarly journals In Vitro Activity of ABT-773, a New Ketolide, against Recent Clinical Isolates of Streptococcus pneumoniae, Haemophilus influenzae, andMoraxella catarrhalis

2000 ◽  
Vol 44 (2) ◽  
pp. 447-449 ◽  
Author(s):  
Angela B. Brueggemann ◽  
Gary V. Doern ◽  
Holly K. Huynh ◽  
Elizabeth M. Wingert ◽  
Paul R. Rhomberg
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Moraxella Catarrhalis ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
In Vitro Activity

ABSTRACT The in vitro activity of ABT-773 was evaluated againstStreptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis isolates. ABT-773 was the most active antimicrobial tested against S. pneumoniae. ABT-773 and azithromycin were equivalent in activity against H. influenzae and M. catarrhalis and more active than either clarithromycin or erythromycin.

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