Role of striatal acetylcholine on dopamine D 1 receptor agonist-induced turning behavior in 6-hydroxydopamine lesioned rats: a microdialysis-behavioral study

2001 ◽  
Vol 22 (1) ◽  
pp. 63-64 ◽  
Author(s):  
S. Fenu ◽  
E. Acquas ◽  
G. Di Chiara
Keyword(s):  
Receptor Agonist ◽  
Behavioral Study ◽  
Turning Behavior ◽  
6 Hydroxydopamine

The role of adenosine receptor agonist and antagonist on Hippocampal MDMA detrimental effects; a structural and behavioral study

2012 ◽  
Vol 27 (4) ◽  
pp. 459-469 ◽  
Author(s):  
Fatemeh Kermanian ◽  
Mehdi Mehdizadeh ◽  
Mansureh Soleimani ◽  
Ali Reza Ebrahimzadeh Bideskan ◽  
Majid Asadi-Shekaari ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Receptor Agonist ◽  
Behavioral Study ◽  
Adenosine Receptor Agonist ◽  
Agonist And Antagonist

Chronic administration of the histamine H3 receptor agonist immepip decreases l-Dopa-induced dyskinesias in 6-hydroxydopamine-lesioned rats

2019 ◽  
Vol 236 (6) ◽  
pp. 1937-1948 ◽  
Author(s):  
Alberto Avila-Luna ◽  
Camilo Ríos ◽  
Arturo Gálvez-Rosas ◽  
Sergio Montes ◽  
José-Antonio Arias-Montaño ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Chronic Administration ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
6 Hydroxydopamine ◽  
Histamine H3

scholarly journals The Protective Role of Brain CYP2J in Parkinson’s Disease Models

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Yueran Li ◽  
Jinhua Wu ◽  
Xuming Yu ◽  
Shufang Na ◽  
Ke Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Brain Regions ◽  
Protective Role ◽  
Neural Cells ◽  
Endogenous Substrates ◽  
6 Hydroxydopamine ◽  
Myd88 Signaling ◽  
Lps Treatment

CYP2J proteins are present in the neural cells of human and rodent brain regions. The aim of this study was to investigate the role of brain CYP2J in Parkinson’s disease. Rats received right unilateral injection with lipopolysaccharide (LPS) or 6-hydroxydopamine (6-OHDA) in the substantia nigra following transfection with or without the CYP2J3 expression vector. Compared with LPS-treated rats, CYP2J3 transfection significantly decreased apomorphine-induced rotation by 57.3% at day 12 and 47.0% at day 21 after LPS treatment; moreover, CYP2J3 transfection attenuated the accumulation of α-synuclein. Compared with the 6-OHDA group, the number of rotations by rats transfected with CYP2J3 decreased by 59.6% at day 12 and 43.5% at day 21 after 6-OHDA treatment. The loss of dopaminergic neurons and the inhibition of the antioxidative system induced by LPS or 6-OHDA were attenuated following CYP2J3 transfection. The TLR4-MyD88 signaling pathway was involved in the downregulation of brain CYP2J induced by LPS, and CYP2J transfection upregulated the expression of Nrf2 via the inhibition of miR-340 in U251 cells. The data suggest that increased levels of CYP2J in the brain can delay the pathological progression of PD initiated by inflammation or neurotoxins. The alteration of the metabolism of the endogenous substrates (e.g., AA) could affect the risk of neurodegenerative disease.

Intra-median raphe nucleus (MRN) infusions of muscimol, a GABA-A receptor agonist, reinstate alcohol seeking in rats: role of impulsivity and reward

2007 ◽  
Vol 195 (4) ◽  
pp. 605-615 ◽  
Author(s):  
Anh Lê Dzung ◽  
Douglas Funk ◽  
Stephen Harding ◽  
Walter Juzytsch ◽  
Zhaoxia Li ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Raphe Nucleus ◽  
Median Raphe ◽  
Median Raphe Nucleus ◽  
Gaba A ◽  
Median Raphé ◽  
Alcohol Seeking

scholarly journals Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making

2009 ◽  
Vol 29 (8) ◽  
pp. 1678-1691 ◽  
Author(s):  
Mark E. Walton ◽  
James Groves ◽  
Katie A. Jennings ◽  
Paula L. Croxson ◽  
Trevor Sharp ◽  
...  
Keyword(s):  
Decision Making ◽  
Nucleus Accumbens ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
6 Hydroxydopamine

In vivo role of BDNF cleavage: Behavioral study of the mutant mice using test battery

2009 ◽  
Vol 65 ◽  
pp. S254
Author(s):  
Haruko Kumanogoh ◽  
Mitsuru Ohtsuka ◽  
Tomoko Hara ◽  
Yoshiko Urbanczyk ◽  
Keizo Takao ◽  
...  
Keyword(s):  
Test Battery ◽  
Mutant Mice ◽  
Behavioral Study
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