Cerebrospinal fluid examination in the differential diagnosis of inflammatory myelopathies

2001 ◽  
Vol 22 (8) ◽  
pp. S65-S68 ◽  
Author(s):  
P. Perini ◽  
M. Calabrese ◽  
F. Ranzato ◽  
M. Tiberio ◽  
P. Gallo
Keyword(s):  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Cerebrospinal Fluid Examination

Meningitis Due to Mumps Virus in a Child with Acute Leukemia

PEDIATRICS ◽  
1970 ◽  
Vol 46 (6) ◽  
pp. 942-945
Author(s):  
Lothar M.T. Rupprecht ◽  
J. Lawrence Naiman
Keyword(s):  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Virus Infection ◽  
Acute Leukemia ◽  
Cell Count ◽  
Mononuclear Cell ◽  
Viral Meningitis ◽  
Mumps Virus ◽  
Leukemic Infiltration ◽  
Cerebrospinal Fluid Examination

An 8½-year-old boy with leukemia in remission developed a meningitis-like syndrome associated with increased mononuclear cell count in the cerebrospinal fluid. Examination of the stained CSF sediment showed these to be small lymphocytes rather than lymphoblasts, suggesting a diagnosis of viral meningitis rather than leukemic infiltration of the meninges. Serologic studies gave evidence of a recent mumps virus infection. Viral meningitis should not be overlooked in the differential diagnosis of meningeal reactions in children with leukemia.

scholarly journals Meningitis in adult patients with a negative direct cerebrospinal fluid examination: value of cytochemical markers for differential diagnosis

Critical Care ◽  
2011 ◽  
Vol 15 (3) ◽  
pp. R136 ◽  
Author(s):  
Alain Viallon ◽  
Nicolas Desseigne ◽  
Olivier Marjollet ◽  
Albert Birynczyk ◽  
Mathieu Belin ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Adult Patients ◽  
Cerebrospinal Fluid Examination ◽  
Cytochemical Markers

Event-related Potentials Improve the Efficiency of Cerebrospinal Fluid Biomarkers for Differential Diagnosis of Alzheimer’s Disease

2018 ◽  
Vol 15 (13) ◽  
pp. 1244-1260 ◽  
Author(s):  
Mirjana Babić Leko ◽  
Magdalena Krbot Skorić ◽  
Nataša Klepac ◽  
Fran Borovečki ◽  
Lea Langer Horvat ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Tau Protein ◽  
Strong Correlation ◽  
Event Related Potentials ◽  
P300 Latency ◽  
Protein Biomarkers ◽  
Related Potentials ◽  
T Tau

Introduction: The pathological process of Alzheimer's disease (AD) in the brain likely begins 20-30 years earlier than the emergence of its first clinical symptoms and symptoms of AD often overlap with the symptoms of other primary causes of dementia. Therefore, it is crucially important to improve early and differential diagnosis of the disease. Event-related potentials (ERP) measured non-invasively by electroencephalography have shown diagnostic potential in AD. Aims: The aim of this study was to compare the efficiency of P300 and N200 potentials and reaction time (RT) with commonly used protein biomarkers measured in the cerebrospinal fluid (CSF), including amyloid β peptide (β1-42), total tau (t-tau), tau protein phosphorylated at threonine 181 (p-tau181), tau protein phosphorylated at serine 199 (p-tau199), tau protein phosphorylated at threonine 231 (p-tau231), and visinin-like protein 1 (VILIP-1) in differential diagnosis of AD in mild cognitive impairment (MCI) and AD patients. Subjects: The study involved 49 AD patients, 28 patients with MCI, 4 healthy control subjects and 16 patients with other primary causes of dementia. Results: ERP (P300RT, N200RT, P300 counting and N200 counting) showed a moderate to strong correlation with protein CSF biomarkers. We confirmed previous observations of moderate to strong correlation between ERP and neuropsychological testing and showed that P300 latency and RT are shortened in AD patients on therapy with acetylcholinesterase inhibitors. Using ERP and RT, a predictive model for determination of AD likelihood in MCI patients was developed, detecting 56.3% of MCI patients with high risk for development of AD in our cohort. MCI patients with pathological levels of Aβ1-42 had prolonged P300 latency, indicating that a combination of ERP and CSF protein biomarkers could improve the differential diagnosis of AD in MCI patients. Additionally, the results suggested the potential of P300 latency in differentiating AD and FTD patients. Conclusion: Our data provide possible solutions for improvement of differential diagnosis of AD, and reveal that the diagnostic efficiency of CSF protein biomarkers t-tau, p-tau181, p-tau199, p-tau231 and VILIP-1 could be improved by adding ERP in clinical practice.

Folate analysis for the differential diagnosis of profound cerebrospinal fluid folate deficiency

2011 ◽  
Vol 44 (8-9) ◽  
pp. 719-721 ◽  
Author(s):  
Aida Ormazábal ◽  
Belén Perez-Dueñas ◽  
Cristina Sierra ◽  
Roser Urreitzi ◽  
Julio Montoya ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Folate Deficiency

scholarly journals Isolated velopalatine paralysis associated with parvovirus B19 infection

2006 ◽  
Vol 64 (3a) ◽  
pp. 603-605 ◽  
Author(s):  
João P. Soares-Fernandes ◽  
Ricardo Maré
Keyword(s):  
Cerebrospinal Fluid ◽  
Nerve Palsy ◽  
Parvovirus B19 ◽  
Brain Mri ◽  
Sudden Onset ◽  
Recent Infection ◽  
Positive Data ◽  
Cerebrospinal Fluid Examination ◽  
Parvovirus B19 Infection

A case of isolated velopalatine paralysis in an 8-year-old boy is presented. The symptoms were sudden-onset of nasal speech, regurgitation of liquids into the nose and dysphagia. Brain MRI and cerebrospinal fluid examination were normal. Infectious serologies disclosed an antibody arrangement towards parvovirus B19 that was typical of recent infection. In the absence of other positive data, the possibility of a correlation between the tenth nerve palsy and parvovirus infection is discussed.

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