Age-dependent neurologic manifestations of HIV infection in childhood

2000 ◽  
Vol 21 (3) ◽  
pp. 135-142 ◽  
Author(s):  
L. Angelini ◽  
F. Zibordi ◽  
F. Triulzi ◽  
P. Cinque ◽  
B. Giudici ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Neurologic Manifestations ◽  
Age Dependent

Neurologic manifestations of HIV infection

1998 ◽  
Vol 103 (3) ◽  
pp. 147-161 ◽  
Author(s):  
Anita R. Rachlis
Keyword(s):  
Hiv Infection ◽  
Neurologic Manifestations

NEUROLOGIC MANIFESTATIONS OF HIV INFECTION

1996 ◽  
Vol 80 (6) ◽  
pp. 1363-1394 ◽  
Author(s):  
David M. Simpson ◽  
Joseph R. Berger
Keyword(s):  
Hiv Infection ◽  
Neurologic Manifestations

Neurologic Manifestations of Human Immunodeficiency Virus Infection in Children

PEDIATRICS ◽  
1986 ◽  
Vol 78 (4) ◽  
pp. 678-687
Author(s):  
Leon G. Epstein ◽  
Leroy R. Sharer ◽  
James M. Oleske ◽  
Edward M. Connor ◽  
Jaap Goudsmit ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
Neutralizing Antibodies ◽  
Fatal Outcome ◽  
Perinatal Period ◽  
Neurologic Manifestations ◽  
Progressive Encephalopathy ◽  
Immunodeficiency Virus ◽  
Aids Related Complex ◽  
Related Complex

This report describes the neurologic manifestations of 36 children with human immunodeficiency virus (HIV) infection. In this cohort, in 16 of 21 children with acquired immunodeficiency syndrome (AIDS), three of 12 children with AIDS-related complex, and one of three asymptomatic seropositive children, a progressive encephalopathy developed. Neurologic signs were often detected early but tended to worsen coincident with progression of the immunodeficiency. The presence of progressive encephalopathy correlated with the absence of serum neutralizing antibodies to HIV and with a poor, usually fatal, outcome. The incubation period from initial HIV infection in the perinatal period to the onset of progressive encephalopathy varied from 2 months to 5 years. Intrablood-brain barrier synthesis of HIV-specific antibodies was demonstrated in eight of 14 children with AIDS and AIDS-related complex, indicating active brain infection with HIV. In three cases this was unassociated with progressive neurologic signs. Unique neuropathologic findings in children who died with HIV infection further suggest that the progressive encephalopathy is the result of primary and persistent infection of the brain with this retrovirus. These findings broaden the spectrum of HIV infection in children and have important implications for the development of antiviral therapy.

Neurologic Manifestations of HIV Infection Without AIDS:

1996 ◽  
Vol 1 (2) ◽  
pp. 41-65
Author(s):  
Christina M. Marra ◽  
W. T. Longstreth ◽  
H. Hunter Handsfield ◽  
Brenda D. Townes ◽  
Robert W. Coombs ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Neurologic Manifestations

scholarly journals ESTIMATING BURDEN OF DISEASE DUE TO CONTINUOUS PROPAGATION OF HIV INFECTION AMONG INJECTING DRUG USERS

2020 ◽  
Vol 12 (1) ◽  
pp. 97-104
Author(s):  
A. N. Barinova ◽  
A. A. Lebedeva ◽  
N. N. Ladnaya ◽  
E. E. Zaytseva ◽  
S. L. Plavinskii
Keyword(s):  
Hiv Infection ◽  
Russian Federation ◽  
Drug Users ◽  
Injecting Drug Users ◽  
Disability Adjusted Life Years ◽  
Long Period ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Age Dependent ◽  
Average Loss

Despite long period of propagation of HIV infection among injecting drug users (IDU) in Russian Federation there is still capacity for appearance of new cases. Based on results of integrated bio-behavioral study conducted in six cities of Russian Federation burden of HIV infection was estimated. Several approaches to calculate disability-adjusted life years (DALY) were used. Estimates of DALY depend mostly on mortality associated with HIV infection. It was shown, that estimates also change depending on changing age-dependent productivity and discount rate. Average loss was estimated at 15,1 DALY per one case of infection. Extrapolating these results on Russian Federation as a whole show that due to continuation of HIV spread among IDU every year 595 thousand DALYs are lost. Summary measures of public health should be used to prioritize investment in prevention.

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