Mitochondria in muscle cell death

1999 ◽  
Vol 20 (6) ◽  
pp. 395-400 ◽  
Author(s):  
P. Bernardi
Keyword(s):  
Cell Death ◽  
Muscle Cell

scholarly journals A link between smooth muscle cell death and extracellular matrix degradation during vascular atrophy

2011 ◽  
Vol 54 (1) ◽  
pp. 182-191.e24 ◽  
Author(s):  
Richard D. Kenagy ◽  
Seung-Kee Min ◽  
Eileen Mulvihill ◽  
Alexander W. Clowes
Keyword(s):  
Extracellular Matrix ◽  
Cell Death ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Matrix Degradation ◽  
Extracellular Matrix Degradation

scholarly journals Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Mari Kamiya ◽  
Fumitaka Mizoguchi ◽  
Kimito Kawahata ◽  
Dengli Wang ◽  
Masahiro Nishibori ◽  
...  
Keyword(s):  
Cell Death ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Muscle Cell ◽  
Muscle Injury ◽  
Fas Ligand ◽  
Muscle Fibers ◽  
Inflammatory Molecules

AbstractMuscle cell death in polymyositis is induced by CD8+ cytotoxic T lymphocytes. We hypothesized that the injured muscle fibers release pro-inflammatory molecules, which would further accelerate CD8+ cytotoxic T lymphocytes-induced muscle injury, and inhibition of the cell death of muscle fibers could be a novel therapeutic strategy to suppress both muscle injury and inflammation in polymyositis. Here, we show that the pattern of cell death of muscle fibers in polymyositis is FAS ligand-dependent necroptosis, while that of satellite cells and myoblasts is perforin 1/granzyme B-dependent apoptosis, using human muscle biopsy specimens of polymyositis patients and models of polymyositis in vitro and in vivo. Inhibition of necroptosis suppresses not only CD8+ cytotoxic T lymphocytes-induced cell death of myotubes but also the release of inflammatory molecules including HMGB1. Treatment with a necroptosis inhibitor or anti-HMGB1 antibodies ameliorates myositis-induced muscle weakness as well as muscle cell death and inflammation in the muscles. Thus, targeting necroptosis in muscle cells is a promising strategy for treating polymyositis providing an alternative to current therapies directed at leukocytes.

scholarly journals Maduramicin induces cardiac muscle cell death by the ROS‐dependent PTEN/Akt–Erk1/2 signaling pathway

2018 ◽  
Vol 234 (7) ◽  
pp. 10964-10976 ◽  
Author(s):  
Xin Chen ◽  
Yue Li ◽  
Meng Feng ◽  
Xiaoyu Hu ◽  
Hai Zhang ◽  
...  
Keyword(s):  
Cell Death ◽  
Cardiac Muscle ◽  
Signaling Pathway ◽  
Muscle Cell ◽  
Cardiac Muscle Cell

scholarly journals Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis

2018 ◽  
Vol 114 (4) ◽  
pp. 622-634 ◽  
Author(s):  
Mandy O J Grootaert ◽  
Manon Moulis ◽  
Lynn Roth ◽  
Wim Martinet ◽  
Cécile Vindis ◽  
...  
Keyword(s):  
Cell Death ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell

scholarly journals Muscle cell death during the development of head and neck muscles in the chick embryo

1995 ◽  
Vol 202 (4) ◽  
pp. 365-377 ◽  
Author(s):  
Deedra McClearn ◽  
Richard Medville ◽  
Drew Noden
Keyword(s):  
Cell Death ◽  
Chick Embryo ◽  
Head And Neck ◽  
Muscle Cell ◽  
Neck Muscles

PET Imaging of Denervation-Induced Muscle Cell Death with 18F-ML-10, a Novel Apoptosis Tracer (P07.198)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P07.198-P07.198
Author(s):  
A. Reshef ◽  
M. Ben-Ami ◽  
N. Freedman ◽  
T. Davidson ◽  
E. Mishani ◽  
...  
Keyword(s):  
Cell Death ◽  
Muscle Cell ◽  
Pet Imaging
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