Levels of Rheumatoid Factor Isotypes, Metalloproteinase-3 and Tissue Inhibitor of Metalloproteinase-1 in Synovial Fluid from Various Arthritides

2000 ◽  
Vol 19 (1) ◽  
pp. 14-20 ◽  
Author(s):  
Y. Kageyama ◽  
S. Miyamoto ◽  
T. Ozeki ◽  
M. Hiyoshi ◽  
M. Suzuki ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Rheumatoid Factor ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Tissue Inhibitor ◽  
Rheumatoid Factor Isotypes

Matrix metalloproteinase and tissue inhibitor of metalloproteinase in serum and synovial fluid of osteoarthritic dogs

2006 ◽  
Vol 19 (01) ◽  
pp. 49-55 ◽  
Author(s):  
J. K. Roush ◽  
T. Schermerhorn ◽  
K. E. Mitchell ◽  
B. J. Salinardi
Keyword(s):  
Mass Spectrometry ◽  
Synovial Fluid ◽  
Matrix Metalloproteinase ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Tissue Inhibitor ◽  
Matrix Metalloproteinase 1 ◽  
Early Oa

SummaryTo better understand the mechanisms responsible for the pathological processes of osteoarthritis (OA) and to potentially identify a profile of changes that could be predictive of early OA, matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in the synovial fluid and serum of normal and osteoarthritic dogs were examined. The concentration of MMP-1 in the synovial fluid of osteoarthritic dogs (0.62 ± 0.16), as measured by densitometry, was significantly higher than that found in control dogs (0.42 ± 0.19) (P = 0.03). The concentration of MMP-1 in the serum of osteoarthritic dogs (0.74 ± 0.16) was significantly less than that found in control dogs (0.87 ± 0.08) (P = 0.05). The concentration of TIMP-2 in the synovial fluid of osteoarthritic dogs (46.2 ± 21.9 ng/ml) was significantly less than that of control dogs (122.0 ± 66.5 ng/ml) (P = 0.009). The concentration of TIMP-2 in the serum of osteoarthritic dogs (116.2 ± 43.1 ng/ml) was not significantly different than that of control dogs (95.1 ± 94.4 ng/ml) (P = 0.554). In addition, a phospho-tyrosine immunoprecipitation and mass spectrometry were used to isolate and identify interferonalpha in canine synovial fluid.

Rheumatoid Factor in Serum and Synovial Fluid

1972 ◽  
Vol 1 (4) ◽  
pp. 177-180 ◽  
Author(s):  
R. N. M. Macsween ◽  
T. K. Dalakos ◽  
M. K. Jasani ◽  
W. W. Buchanan ◽  
T. K. Dalakos
Keyword(s):  
Synovial Fluid ◽  
Rheumatoid Factor
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