Level and avidity of antineutrophil cytoplasmic antibodies specific to lactoferrin are useful biomarkers in systemic lupus erythematosus

2021 ◽  
Author(s):  
Mirjana Gajic-Veljic ◽  
Branislav Lekic ◽  
Milos Nikolic ◽  
Jovan Lalosevic ◽  
Biljana Stojimirovic ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Systemic Lupus

scholarly journals ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS

Rheumatology ◽  
1996 ◽  
Vol 35 (7) ◽  
pp. 625-631 ◽  
Author(s):  
P. E. SPRONK ◽  
H. BOOTSMA ◽  
G. HORST ◽  
M. G. HUITEMA ◽  
P. C. LIMBURG ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Systemic Lupus

Antineutrophil cytoplasmic antibodies in patients with systemic lupus erythematosus

2002 ◽  
Vol 27 (1) ◽  
pp. 59-61 ◽  
Author(s):  
K. Molnár ◽  
L. Kovács ◽  
M. Kiss ◽  
S. Husz ◽  
A. Dobozy ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Systemic Lupus

scholarly journals Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus

1995 ◽  
Vol 38 (5) ◽  
pp. 633-637 ◽  
Author(s):  
Armin Schnabel ◽  
Elena Csernok ◽  
David A. Isenberg ◽  
Christian Mrowka ◽  
Wolfgang L. Gross
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Systemic Lupus

scholarly journals A Case of Systemic Lupus Erythematosus and Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis Overlap Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Hiroyuki Hounoki ◽  
Koichiro Shinoda ◽  
Atsushi Matsui ◽  
Maiko Okumura ◽  
Satoshi Yamaguchi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Renal Biopsy ◽  
Lupus Erythematosus ◽  
Leukocytoclastic Vasculitis ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Systemic Lupus ◽  
Crescent Formation ◽  
Mesangial Area ◽  
Necrotizing Glomerulonephritis ◽  
Cyclophosphamide Pulse

An overlap of systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic antibodies- (ANCA-) associated vasculitis (AAV) is extremely rare: approximately 40 cases have been reported to date. A literature review indicates that they are more common in women in their forties, and simultaneous onset has been reported in 69% of cases. In addition, both lupus nephritis and ANCA-associated glomerulonephritis were observed on renal biopsy. This report presents the case of a 35-year-old woman with an 8-month history of polyarthralgia who was admitted to our hospital. She was diagnosed with SLE due to typical clinical presentation of the disease: polyarthritis, lymphocytopenia, hypocomplementemia, presence of antinuclear and anti-dsDNA antibodies, and proteinuria. However, purpura were scattered, and the titer of antimyeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCA) was high. A skin biopsy revealed leukocytoclastic vasculitis that involved poor immune complex deposition. A renal biopsy showed necrotizing glomerulonephritis with cellular and fibrocellular crescent formation that involved deposition of IgM and C3c only in the mesangial area and the peripheral capillaries. Additionally, no electron-dense deposits were observed under electron microscopy. These pathological findings were consistent with AAV rather than with SLE. Therefore, we finally diagnosed the patient with both SLE and microscopic polyangiitis. After treatment with methylprednisolone and intravenous cyclophosphamide pulse therapies, renal function improved and MPO-ANCA levels decreased. In cases of suspected overlap between SLE and AAV, appropriate diagnosis and treatment are important.

Antineutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus

1998 ◽  
Vol 17 (3) ◽  
pp. 265-267 ◽  
Author(s):  
A. Bakkaloğlu ◽  
R. Topaloğlu ◽  
U. Saatçi ◽  
S. Özdemir ◽  
S. Özen ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Systemic Lupus

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

“Subcortical” cognitive impairment in patients with systemic lupus erythematosus

2000 ◽  
Vol 6 (7) ◽  
pp. 821-825 ◽  
Author(s):  
ELIZABETH LERITZ ◽  
JASON BRANDT ◽  
MELISSA MINOR ◽  
FRANCES REIS-JENSEN ◽  
MICHELLE PETRI
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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