scholarly journals Infrequent genetic alterations of the PTEN gene in Japanese patients with sporadic prostate cancer

1998 ◽  
Vol 43 (4) ◽  
pp. 228-230 ◽  
Author(s):  
Kazuhiko Orikasa ◽  
Shin-ichi Fukushige ◽  
Senji Hoshi ◽  
Seiichi Orikasa ◽  
Keiichi Kondo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Japanese Patients ◽  
Genetic Alterations ◽  
Pten Gene

scholarly journals Whole exome sequencing and deep sequencing of esophageal squamous cell carcinoma and adenocarcinoma in Japanese patients using the Japanese version of the Genome Atlas, JCGA

Esophagus ◽  
2021 ◽  
Author(s):  
Eisuke Booka ◽  
Yasuhiro Tsubosa ◽  
Tomoya Yokota ◽  
Shuhei Mayanagi ◽  
Kenjiro Ishii ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Somatic Mutations ◽  
Molecular Targets ◽  
Japanese Version ◽  
Japanese Patients ◽  
Genetic Alterations ◽  
Genome Atlas

Abstract Background Recent comprehensive mutation analyses have revealed a relatively small number of driver mutations in esophageal cancer, implicating a limited number of molecular targets, most of which are also implicated in squamous cell carcinoma. Methods In this study, we investigated genetic alterations in 44 esophageal squamous cell carcinomas (ESCC) and 8 adenocarcinomas (EAC) from Japanese patients as potential molecular targets, based on data from the Japanese version of The Genome Atlas (JCGA). Results Esophageal cancer was characterized by TP53 somatic mutations in ESCC (39/44, 88.6%) and EAC (5/8, 62.5%). In addition to TP53 mutations, somatic mutations in NFE2L2 (16/44, 36.4%), CDKN2A (7/44, 15.9%), and KMT2D (7/44, 15.9%) were more frequently detected in ESCC than in EAC. WRN-truncated type mutations that lead to genomic instability correlate with EAC, but not ESCC. ESCC samples were enriched in ALDH2-associated mutational signature 16 as well as the APOBEC signature. Patients with FAT2 mutations had significantly poorer overall survival compared with those with wild-type status at FAT2 (p < 0.05). Patients with EP300 or PTPRD mutations also had poor progression-free survival compared with respective wild-types (p < 0.05 or p < 0.001). Conclusions These findings may facilitate future precision medicine approaches based on genomic profiling in ESCC and EAC.

Genetic Alterations at 13q14 May Correlate with Differences in the Biological Behavior of Prostate Cancer between Japanese and Caucasian Men

2010 ◽  
Vol 84 (4) ◽  
pp. 461-466 ◽  
Author(s):  
Taku Misumi ◽  
Yoshiaki Yamamoto ◽  
Tomoyuki Murakami ◽  
Yoshihisa Kawai ◽  
Hideaki Ito ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Genetic Alterations ◽  
Biological Behavior ◽  
Caucasian Men

scholarly journals Implications of Body Mass Index in Japanese Patients with Prostate Cancer Who Had Undergone Radical Prostatectomy

2010 ◽  
Vol 40 (4) ◽  
pp. 353-359 ◽  
Author(s):  
A. Komaru ◽  
N. Kamiya ◽  
H. Suzuki ◽  
T. Endo ◽  
M. Takano ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Radical Prostatectomy ◽  
Body Mass ◽  
Japanese Patients

scholarly journals Prostate Cancer-Specific and Potent Antitumor Effect of a DD3-Controlled Oncolytic Virus Harboring the PTEN Gene

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e35153 ◽  
Author(s):  
Miao Ding ◽  
Xin Cao ◽  
Hai-neng Xu ◽  
Jun-kai Fan ◽  
Hong-ling Huang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Oncolytic Virus ◽  
Antitumor Effect ◽  
Pten Gene

scholarly journals Bone management in Japanese patients with prostate cancer: hormonal therapy leads to an increase in the FRAX score

BMC Urology ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Takashi Kawahara ◽  
Shusei Fusayasu ◽  
Koji Izumi ◽  
Yumiko Yokomizo ◽  
Hiroki Ito ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Hormonal Therapy ◽  
Japanese Patients ◽  
Frax Score

scholarly journals Viral etiology of prostate cancer: Genetic alterations and immune response. A literature review

2018 ◽  
Vol 52 ◽  
pp. 136-140 ◽  
Author(s):  
Syed Hani Abidi ◽  
Fareena Bilwani ◽  
Kulsoom Ghias ◽  
Farhat Abbas
Keyword(s):  
Prostate Cancer ◽  
Immune Response ◽  
Literature Review ◽  
Genetic Alterations ◽  
Cancer Genetic ◽  
Viral Etiology

scholarly journals eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Qi Li ◽  
Mulun Xiao ◽  
Yibo Shi ◽  
Jinhao Hu ◽  
Tianxiang Bi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Translation Initiation ◽  
Genetic Alterations ◽  
Cell Counting ◽  
Migration And Invasion ◽  
Cell Group ◽  
Prostate Cancer Cells ◽  
Normal Prostate

Abstract Background Eukaryotic translation initiation factors (eIFs) are the key factors to synthesize translation initiation complexes during the synthesis of eukaryotic proteins. Besides, eIFs are especially important in regulating the immune function of tumor cells. However, the effect mechanism of eIFs in prostate cancer remains to be studied, which is precisely the purpose of this study. Methods In this study, three groups of prostate cancer cells were investigated. One group had its eIF5B gene knocked down; another group had its Programmed death 1 (PD-L1) overexpressed; the final group had its Wild-type p53-induced gene 1 (Wig1) overexpressed. Genetic alterations of the cancer cells were performed by plasmid transfection. The expression of PD-L1 mRNA was detected by quantitative real-time PCR (qRT-PCR), and the expressions of PD-L1 and eIF5B proteins were observed by western blot assays. Cell Counting Kit-8 (CCK-8), flow cytometry, Transwell and Transwell martrigel were used to investigated cell proliferation, apoptosis, migration and invasion, respectively. The effect of peripheral blood mononuclear cells (PBMCs) on tumor cells was observed, and the interaction between eIF5B and Wig1 was revealed by co-immunoprecipitation (CoIP) assay. Finally, the effects of interference with eIF5B expression on the growth, morphology, and immunity of the tumor, as well as PD-L1 expression in the tumor, were verified by tumor xenograft assays in vivo. Results Compared with normal prostate epithelial cells, prostate cancer cells revealed higher expressions of eIF5B and PD-L1 interference with eIF-5B expression can inhibit the proliferation, migration, invasion and PD-L1 expression of prostate cancer cells. Meanwhile, the cancer cell group with interference with eIF5B expression also demonstrated greater, apoptosis and higher vulnerability to PBMCs. CoIP assays showed that Wig1 could bind to eIF5B in prostate cancer cells, and its overexpression can inhibit the proliferation, migration, invasion and PD-L1 expression of cancer cells while promoting apoptosis. Moreover, interference with eIF5B expression can inhibit tumor growth, destroy tumor morphology, and suppress the proliferation of tumor cells. Conclusion eIF5B can promote the expression of PD-L1 by interacting with Wig1. Besides, interference with eIF5B expression can inhibit the proliferation, migration, invasion and immunosuppressive response of prostate cancer cells. This study proposes a new target, eIF5B, for immunotherapy of prostate cancer.

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