Transition State Thermodynamics of Lipid Bilayers Characterized by Differential Scanning Calorimetry

1997 ◽  
Vol 2 (6) ◽  
pp. 1-17 ◽  
Author(s):  
TONI L. CECKLER ◽  
BETH A. CUNNINGHAM
Keyword(s):  
Differential Scanning Calorimetry ◽  
Transition State ◽  
Lipid Bilayers ◽  
Scanning Calorimetry

scholarly journals The interaction of new oxicam derivatives with lipid bilayers as measured by calorimetry and fluorescence spectroscopy

2018 ◽  
Vol 65 (2) ◽  
pp. 185-191 ◽  
Author(s):  
Jadwiga Maniewska ◽  
Justyna Gąsiorowska ◽  
Berenika Marta Szczęśniak-Sięga ◽  
Krystyna Michalak
Keyword(s):  
Differential Scanning Calorimetry ◽  
Fluorescence Spectroscopy ◽  
Lipid Bilayers ◽  
Carbonyl Group ◽  
Lipid Membrane ◽  
Spectroscopic Studies ◽  
Scanning Calorimetry ◽  
Experimental Approaches ◽  
Inflammatory Drugs ◽  
Thermotropic Properties

The purpose of the present work was to assess the ability of five new oxicam analogues to interact with the lipid bilayers. To characterize the interaction of newly synthesized NSAIDs (non-steroidal anti-inflammatory drugs) analogues with DPPC lipid bilayers the two following techniques were applied – differential scanning calorimetry (DSC) and fluorescence spectroscopy. The results obtained by these experimental approaches show that new oxicams analogues interact with the lipid model membranes under consideration. As demonstrated both in calorimetric and spectroscopic studies, the greatest influence on the thermotropic properties of the lipid membrane and on the quenching of fluorescence of Laurdan and Prodan was exerted by a derivative named PR47 containing in its structure a two–carbon aliphatic linker with a carbonyl group, as well as bromine and trifluoromethyl substituents.

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