Analysis of distributions of amino acids and amino acid pairs in human tumour necrosis factor precursor and its eight mutations according to a random mechanism

2001 ◽  
Vol 7 (9) ◽  
pp. 318-323 ◽  
Author(s):  
Guang Wu ◽  
Shaomin Yan
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Human Tumour ◽  
Random Mechanism ◽  
Human Tumour Necrosis Factor ◽  
Necrosis Factor

scholarly journals A comparison of the Antileukaemic Effects of Recombinant Human Tumour Necrosis Factor-α and its Muteins on Leukaemia L1210 and Leukaemia P388 in Mice

1994 ◽  
Vol 3 (6) ◽  
pp. 411-414 ◽  
Author(s):  
K. Warzocha ◽  
J. Góra-Tybor ◽  
M. Kwinkowski ◽  
B. Szymańska ◽  
T. Robak
Keyword(s):  
Amino Acids ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Treated Group ◽  
Human Tumour ◽  
Necrosis Factor Alpha ◽  
Significant Prolongation ◽  
Tnf Α ◽  
Human Tumour Necrosis Factor ◽  
Necrosis Factor

We investigated the influence of recombinant human tumour necrosis factor alpha (TNF-α) and its derivatives termed muteins III, V, VI—in which the first 3 to 7 amino acids of native TNF-α have been replaced—on the survival time of mice inoculated with leukaemia L1210 or leukaemia P338. TNF-α prolonged the survival of mice with leukaemia L1210 but did not have any therapeutic activity in leukaemia P388-bearing mice. Muteins-treated mice with leukaemia P388 lived longer than animals receiving TNF-α, while those inoculated with leukaemia L1210 did not show any significant prolongation of life compared with the TNF-α treated group. The results presented in this report indicate that the antileukaemic activity of TNF-α is governed at least in part by the nature of the N-terminal amino acids.

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

Nature ◽  
1984 ◽  
Vol 312 (5996) ◽  
pp. 724-729 ◽  
Author(s):  
Diane Pennica ◽  
Glenn E. Nedwin ◽  
Joel S. Hayflick ◽  
Peter H. Seeburg ◽  
Rik Derynck ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Human Tumour ◽  
Precursor Structure ◽  
Human Tumour Necrosis Factor ◽  
Necrosis Factor

Expression and rescuing of a cloned human tumour necrosis factor gene using an EBV-based shuttle cosmid vector.

1987 ◽  
Vol 6 (2) ◽  
pp. 355-361 ◽  
Author(s):  
D. Kioussis ◽  
F. Wilson ◽  
C. Daniels ◽  
C. Leveton ◽  
J. Taverne ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Human Tumour ◽  
Factor Gene ◽  
Human Tumour Necrosis Factor ◽  
Cosmid Vector ◽  
Necrosis Factor

Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor

Nature ◽  
1985 ◽  
Vol 313 (6005) ◽  
pp. 803-806 ◽  
Author(s):  
Takashi Shirai ◽  
Hiroshi Yamaguchi ◽  
Hirataka Ito ◽  
Chas. W. Todd ◽  
R. Bruce Wallace
Keyword(s):  
Escherichia Coli ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Cloning And Expression ◽  
Human Tumour ◽  
Expression In Escherichia Coli ◽  
Human Tumour Necrosis Factor ◽  
Necrosis Factor

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 ◽  
Vol 10 (13) ◽  
pp. 4025-4031 ◽  
Author(s):  
J. Keffer ◽  
L. Probert ◽  
H. Cazlaris ◽  
S. Georgopoulos ◽  
E. Kaslaris ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Genetic Model ◽  
Human Tumour ◽  
Human Tumour Necrosis Factor ◽  
Necrosis Factor
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