Vitamin D receptor gene Bsm I-polymorphism in Finnish premenopausal and postmenopausal women: its association with bone mineral density, markers of bone turnover, and intestinal calcium absorption, with adjustment for lifestyle factors

2002 ◽  
Vol 20 (6) ◽  
pp. 383-390 ◽  
Author(s):  
Marika Laaksonen ◽  
Merja Kärkkäinen ◽  
Terhi Outila ◽  
Tarja Vanninen ◽  
Carola Ray ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Vitamin D Receptor ◽  
Calcium Absorption ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Mineral Density ◽  
Markers Of Bone Turnover

scholarly journals Vitamin D Receptor Gene Fok1 Polymorphism Predicts Calcium Absorption and Bone Mineral Density in Children

1999 ◽  
Vol 14 (5) ◽  
pp. 740-746 ◽  
Author(s):  
Sharla K. Ames ◽  
Kenneth J. Ellis ◽  
Sheila K. Gunn ◽  
Kenneth C. Copeland ◽  
Steven A. Abrams
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Vitamin D Receptor ◽  
Calcium Absorption ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Mineral Density

scholarly journals The Relationship between Polymorphisms in the Vitamin D Receptor Gene and Bone Mineral Density in Postmenopausal Women

ISRN Genetics ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Jose M. Moran ◽  
Francisco J. Rodriguez-Velasco ◽  
Raul Roncero-Martin ◽  
Purificación Rey-Sanchez ◽  
Mariana Martinez ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Mineral Density ◽  
Gene Environment

The objective of this study was to identify, through a systematic review of the literature, Vitamin D receptor gene (VDR) polymorphisms related to osteoporosis and their effects on bone mineral density (BMD). The articles dated between January 2000 and December 2011 in the Scielo and PubMed databases were reviewed. A total of 23 articles that studied the association between the BsmI, ApaI, FokI, and TaqI polymorphisms and bone mineral density in postmenopausal women were selected. We found systematic studies/meta-analysis (level E-I) and case-control/cohort (level E-IV) studies. No definite conclusions can be made regarding the association of BsmI, ApaI, FokI, and TaqI polymorphisms with BMD among postmenopausal women. Larger and more rigorous analytical studies with consideration of gene-gene/environment interactions are needed to further dissect the mechanisms by which VDR alleles influence BMD.

scholarly journals Association of vitamin D receptor gene polymorphism with a bone mineral density level in postmenopausal women

2019 ◽  
Vol 16 (2) ◽  
pp. 192-201 ◽  
Author(s):  
A. V. Rudenka ◽  
E. V. Rudenka ◽  
V. Yu. Samokhovec ◽  
K. V. Kobets ◽  
P. M. Marozik
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Gene Polymorphism ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Gene Variant ◽  
Mineral Density

The analysis of association of polymorphic variants of the vitamin D receptor gene (VDR) with bone mineral density (BMD) values in menopausal women was performed. The study included 66 patients with postmenopausal osteoporosis (PMO group) and 170 postmenopausal women with normal BMD values (CON group). The statistically significant difference between the analyzed groups in the genotypes and the alleles frequency distribution for the VDR ApaI gene variant was revealed: for the carriers of C/C genotype, the risk of osteoporosis was higher compared to individuals with A/A genotype (OR = 2.7 [95 % CI: 1.5–4.7], p = 0.002). Allele A was overrepresented in the CON group and associated with the reduced risk of disease (OR = 0.6 [95 % CI: 0.4–0.8], p = 0.001). Statistically significant differences were found between the studied groups when analyzing VDR BsmI gene variant distribution. For the individuals with the unfavorable VDR BsmI G/G-genotype, the risk of PMO was significantly higher when compared to the carriers of the A/A-genotype (OR = 2.1 [95 % CI: 1.0–4.4], p = 0.02). For the bearers of A-allele, the risk of osteoporosis was significantly lower (OR = 0.6 [95 % CI: 0.4–0.9], p = 0.007). Among the carriers of the VDR ApaI C/C-genotype, the average BMD level was by 13.7 % lower compared to the carriers of the VDR ApaI A/A-genotype (0.767 and 0.872 g/cm2, respectively, p = 0.04); among individuals with the TaqI C/C-genotype, the BMD level was by 13.8 % lower compared to TaqI T/T-genotype bearers (0.803 and 0.914 g/cm2, respectively, p = 0.03). VDR gene polymorphism may play an important role in the susceptibility to osteoporosis and is significantly associated with the BMD level in postmenopausal women.

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