Low dose of human PTH(1-34) improved tibial subcortical bone mass without further cortical bone loss in adult intact beagles

1998 ◽  
Vol 16 (2) ◽  
pp. 96-99 ◽  
Author(s):  
Liu Zhang ◽  
Hideaki E. Takahashi ◽  
Tatsuhiko Tanizawa ◽  
Naoto Endo ◽  
Noriaki Yamamoto ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Mass ◽  
Cortical Bone ◽  
Low Dose ◽  
Cortical Bone Loss

Relation of axial bone mass to habitual calcium intake and to cortical bone loss in healthy early postmenopausal women

Maturitas ◽  
1991 ◽  
Vol 13 (1) ◽  
pp. 85
Author(s):  
E.C.H. Van Beresteijn ◽  
M.A. Van't Hof ◽  
H. De Waard ◽  
J.A. Raymakers ◽  
S.A. Duursma
Keyword(s):  
Bone Loss ◽  
Bone Mass ◽  
Cortical Bone ◽  
Postmenopausal Women ◽  
Calcium Intake ◽  
Cortical Bone Loss ◽  
Early Postmenopausal Women

Relation of axial bone mass to habitual calcium intake and to cortical bone loss in healthy early postmenopausal women

Bone ◽  
1990 ◽  
Vol 11 (1) ◽  
pp. 7-13 ◽  
Author(s):  
E.C.H. van Beresteijn ◽  
M.A. van't Hof ◽  
H. de Waard ◽  
J.A. Raymakers ◽  
S.A. Duursma
Keyword(s):  
Bone Loss ◽  
Bone Mass ◽  
Cortical Bone ◽  
Postmenopausal Women ◽  
Calcium Intake ◽  
Cortical Bone Loss ◽  
Early Postmenopausal Women

scholarly journals Mmp-13 deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice

2021 ◽  
Author(s):  
Filipa Ponte ◽  
Ha-Neui Kim ◽  
Aaron Warren ◽  
Srividhya Iyer ◽  
Li Han ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Mass ◽  
Protective Effect ◽  
Trabecular Bone ◽  
Cortical Bone ◽  
Cortical Thickness ◽  
Mesenchymal Cell ◽  
Estrogen Deficiency ◽  
Cortical Bone Loss ◽  
Osteoclast Number

The protective effect of estrogens against cortical bone loss is mediated via direct actions on mesenchymal lineage cells, but functional evidence for the precise molecular mechanism(s) and the mediators of these effects has only recently began to emerge. We report that the matrix metalloproteinase 13 (MMP-13) is the highest up-regulated gene in calvaria or bone marrow cells from mice lacking the estrogen receptor (ER) alpha in osteoprogenitors. We, therefore, generated mice with conditional Mmp-13 deletion in Prrx1 expressing cells ( Mmp-13 ?Prrx1 ) and compared the effect of estrogen deficiency on their bone phenotype to that of control littermates ( Mmp-13 f/f ). Femur and tibia length was decreased in sham-operated Mmp-13 ?Prrx1 mice as compared to Mmp1 3 f/f . Cortical thickness and trabecular bone volume in the femur and tibia were increased and osteoclast number at the endocortical surfaces was decreased in the sham-operated female Mmp13 ?Prrx1 mice; whereas bone formation rate was unaffected. Ovariectomy (OVX) caused a decrease of cortical thickness in the femur and tibia of Mmp-13 f/f control mice. This effect was attenuated in the Mmp-13 ? Prrx1 mice; but the decrease of trabecular bone caused by OVX was not affected. These results reveal that mesenchymal cell–derived MMP-13 regulates osteoclast number, bone resorption, and bone mass. We have recently reported that the loss of cortical, but not trabecular bone, caused by OVX is also attenuated in Cxcl12 ?Prrx1 mice. Together with the present report, this functional genetic evidence provides proof of principle that increased production of mesenchymal cell-derived factors, such as CXCL12 and MMP-13, are important mediators of the adverse effect of estrogen deficiency on cortical, but not trabecular, bone. Therefore, the mechanisms responsible for the protective effect of estrogens on these two major bone compartments are different.

Unloading-Induced Cortical Bone Loss is Exacerbated by Low-Dose Irradiation During a Simulated Deep Space Exploration Mission

2020 ◽  
Vol 107 (2) ◽  
pp. 170-179 ◽  
Author(s):  
Antoine Farley ◽  
Vasily Gnyubkin ◽  
Arnaud Vanden-Bossche ◽  
Norbert Laroche ◽  
Mieke Neefs ◽  
...  
Keyword(s):  
Bone Loss ◽  
Cortical Bone ◽  
Low Dose ◽  
Space Exploration ◽  
Deep Space ◽  
Cortical Bone Loss ◽  
Deep Space Exploration ◽  
Dose Irradiation ◽  
Exploration Mission

Supportive Role of Probiotic Strains in Protecting Rats from Ovariectomy-Induced Cortical Bone Loss

2018 ◽  
Vol 11 (4) ◽  
pp. 1145-1154 ◽  
Author(s):  
Nima Montazeri-Najafabady ◽  
Younes Ghasemi ◽  
Mohammad Hossein Dabbaghmanesh ◽  
Pedram Talezadeh ◽  
Farhad Koohpeyma ◽  
...  
Keyword(s):  
Bone Loss ◽  
Cortical Bone ◽  
Cortical Bone Loss ◽  
Supportive Role ◽  
Probiotic Strains

scholarly journals Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence

JCI Insight ◽  
2020 ◽  
Vol 5 (19) ◽  
Author(s):  
Ha-Neui Kim ◽  
Jinhu Xiong ◽  
Ryan S. MacLeod ◽  
Srividhya Iyer ◽  
Yuko Fujiwara ◽  
...  
Keyword(s):  
Bone Loss ◽  
Cortical Bone ◽  
Cortical Bone Loss

Biomechanical Effects of the Nail Entry Zone and Anterior Cortical Bone Loss on the Proximal Tibia

2013 ◽  
Vol 27 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Hassan R. Mir ◽  
Ruxi C. Marinescu ◽  
Haden Janda ◽  
Thomas A. Russell
Keyword(s):  
Bone Loss ◽  
Cortical Bone ◽  
Proximal Tibia ◽  
Entry Zone ◽  
Cortical Bone Loss

scholarly journals Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice

2018 ◽  
Vol 238 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Thomas Funck-Brentano ◽  
Karin H Nilsson ◽  
Robert Brommage ◽  
Petra Henning ◽  
Ulf H Lerner ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Bone Formation ◽  
Bone Mass ◽  
Trabecular Bone ◽  
Cortical Bone ◽  
Bone Strength ◽  
Bending Test ◽  
Bone Homeostasis ◽  
Mineral Density

WNT signaling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation of WNTs by Porcupine is required for WNT activity. Porcupine inhibitors are under development for cancer therapy. As the possible side effects of Porcupine inhibitors on bone health are unknown, we determined their effects on bone mass and strength. Twelve-week-old C57BL/6N female mice were treated by the Porcupine inhibitors LGK974 (low dose = 3 mg/kg/day; high dose = 6 mg/kg/day) or Wnt-C59 (10 mg/kg/day) or vehicle for 3 weeks. Bone parameters were assessed by serum biomarkers, dual-energy X-ray absorptiometry, µCT and histomorphometry. Bone strength was measured by the 3-point bending test. The Porcupine inhibitors were well tolerated demonstrated by normal body weight. Both doses of LGK974 and Wnt-C59 reduced total body bone mineral density compared with vehicle treatment (P < 0.001). Cortical thickness of the femur shaft (P < 0.001) and trabecular bone volume fraction in the vertebral body (P < 0.001) were reduced by treatment with LGK974 or Wnt-C59. Porcupine inhibition reduced bone strength in the tibia (P < 0.05). The cortical bone loss was the result of impaired periosteal bone formation and increased endocortical bone resorption and the trabecular bone loss was caused by reduced trabecular bone formation and increased bone resorption. Porcupine inhibitors exert deleterious effects on bone mass and strength caused by a combination of reduced bone formation and increased bone resorption. We suggest that cancer targeted therapies using Porcupine inhibitors may increase the risk of fractures.

scholarly journals Metacarpal cortical bone loss and osteoporotic fractures in theCoimbraIdentifiedSkeletalCollection

2018 ◽  
Vol 29 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Francisco Curate ◽  
Andreia Perinha ◽  
Ana Maria Silva ◽  
Eugénia Cunha ◽  
Cláudia Umbelino ◽  
...  
Keyword(s):  
Bone Loss ◽  
Cortical Bone ◽  
Osteoporotic Fractures ◽  
Cortical Bone Loss
Sign in / Sign up

Export Citation Format

Share Document