Plasma total homocysteine and subarachnoid haemorrhage in a co-factor replete population

Amino Acids ◽  
2001 ◽  
Vol 21 (3) ◽  
pp. 237-241 ◽  
Author(s):  
A. W. McEvoy ◽  
C. Marras ◽  
N. D. Kitchen ◽  
A. Briddon
Keyword(s):  
Subarachnoid Haemorrhage ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine

Betaine: a key modulator of one-carbon metabolism and homocysteine status

2005 ◽  
Vol 43 (10) ◽  
Author(s):  
Per Magne Ueland ◽  
Pål I. Holm ◽  
Steinar Hustad
Keyword(s):  
Carbon Metabolism ◽  
Individual Variability ◽  
Vitamin B ◽  
Total Homocysteine ◽  
Altered Metabolism ◽  
One Carbon Metabolism ◽  
And Gender ◽  
Betaine Homocysteine Methyltransferase ◽  
Plasma Total Homocysteine ◽  
Homocysteine Methyltransferase

AbstractBetaine serves as a methyl donor in a reaction converting homocysteine to methionine, catalysed by the enzyme betaine-homocysteine methyltransferase. It has been used for years to lower the concentration of plasma total homocysteine (tHcy) in patients with homocystinuria, and has recently been shown to reduce fasting and in particular post-methionine load (PML) tHcy in healthy subjects.Betaine exists in plasma at concentrations of about 30μmol/L; it varies 10-fold (from 9 to 90μmol/L) between individuals, but the intra-individual variability is small. Major determinants are choline, dimethylglycine and folate in plasma, folic acid intake and gender.Recent studies have demonstrated that plasma betaine is a stronger determinant of PML tHcy than are vitamin BTo conclude, betaine status is a component of an individual's biochemical make-up with ramifications to one-carbon metabolism. Betaine status should be investigated in pathologies related to altered metabolism of homocysteine and folate, including cardiovascular disease, cancer and neural tube defects.

Oral and transdermal estrogens both lower plasma total homocysteine in male-to-female transsexuals

2003 ◽  
Vol 168 (1) ◽  
pp. 139-146 ◽  
Author(s):  
Erik J. Giltay ◽  
Petra Verhoef ◽  
Louis J.G. Gooren ◽  
Johanna M. Geleijnse ◽  
Evert G. Schouten ◽  
...  
Keyword(s):  
Lower Plasma ◽  
Total Homocysteine ◽  
Male To Female ◽  
Plasma Total Homocysteine

scholarly journals Acute effects of tea on fasting and non-fasting plasma total homocysteine concentrations in human subjects

2007 ◽  
Vol 97 (5) ◽  
pp. 842-846 ◽  
Author(s):  
Jonathan M. Hodgson ◽  
Ian B. Puddey ◽  
Frank M. van Bockxmeer ◽  
Valerie Burke
Keyword(s):  
Human Subjects ◽  
Random Order ◽  
Black Tea ◽  
Acute Effect ◽  
Hot Water ◽  
Fasting State ◽  
Cvd Risk ◽  
Acute Increase ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine

Plasma total homocysteine concentrations (tHcy) are a putative risk factor for CVD. Tea is a rich dietary source of polyphenols and caffeine, both of which may raise tHcy. However, it is possible that much of any effect is transitory and may be influenced by the consumption of food. Our objective was to investigate the acute effect of tea, at a dose representative of ordinary population intakes, on tHcy and to determine whether consumption of a meal influences the magnitude of any effect. Measurements of tHcy were performed in twenty participants at baseline and 3.5 h after drinking three cups of black tea or hot water (consumed at time 0, 1.5 and 3 h) with and without a meal: a total of four treatments administered in random order. Drinking tea resulted in an acute increase in tHcy (0·30 (95 % CI 0·04, 0·56) μmol/l, P = 0·022). The meal resulted in an acute decrease in tHcy ( − 0·42 (95 % CI − 0·68, − 0·16) μmol/l, P = 0·002). There was no interaction between tea and meal on tHcy (P = 0·40); that is, the effect of tea on tHcy was not different in the fasting and non-fasting state. Our results suggest that drinking black tea can cause a small acute increase in tHcy and that this effect is not enhanced in the non-fasting state. Given that results of population studies have generally shown a negative association between tea intake and tHcy, the significance of these findings to CVD risk remains uncertain.

Effects of marathon running on plasma total homocysteine concentrations

2005 ◽  
Vol 15 (2) ◽  
pp. 134-139 ◽  
Author(s):  
J.T. Real ◽  
A. Merchante ◽  
J.L. Gómez ◽  
F.J. Chaves ◽  
J.F. Ascaso ◽  
...  
Keyword(s):  
Marathon Running ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine

The effect of N-acetylcysteine on plasma total homocysteine levels in hemodialysis: A randomized, controlled study

2003 ◽  
Vol 41 (2) ◽  
pp. 442-446 ◽  
Author(s):  
Allon N. Friedman ◽  
Andrew G. Bostom ◽  
Priscilla Laliberty ◽  
Jacob Selhub ◽  
Douglas Shemin
Keyword(s):  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine
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