The taurine transporter gene and its role in renal development

Amino Acids ◽  
2000 ◽  
Vol 19 (3-4) ◽  
pp. 499-507 ◽  
Author(s):  
X. Han ◽  
A. M. Budreau ◽  
R. W. Chesney
2002 ◽  
Vol 277 (42) ◽  
pp. 39266-39273 ◽  
Author(s):  
Xiaobin Han ◽  
Andrea Budreau Patters ◽  
Russell W. Chesney

2010 ◽  
Vol 76 (2) ◽  
pp. 381-388 ◽  
Author(s):  
Tomoko Koito ◽  
Ikumi Nakamura-Kusakabe ◽  
Takao Yoshida ◽  
Tadashi Maruyama ◽  
Tamano Omata ◽  
...  

Amino Acids ◽  
2011 ◽  
Vol 42 (6) ◽  
pp. 2267-2274 ◽  
Author(s):  
Loria Bianchi ◽  
Riccardo Lari ◽  
Roberto Anichini ◽  
Alessandra De Bellis ◽  
Angela Berti ◽  
...  

1994 ◽  
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M. Hoff ◽  
J. Holik ◽  
D. Hadley ◽  
N. Fang ◽  
...  

1997 ◽  
Vol 52 (3) ◽  
pp. 748-754 ◽  
Author(s):  
Douglas G. Matsell ◽  
Tracey Bennett ◽  
Xiaobin Han ◽  
Andrea M. Budreau ◽  
Russell W. Chesney

2001 ◽  
Vol 281 (6) ◽  
pp. C1825-C1836 ◽  
Author(s):  
Christy C. Bridges ◽  
M. Shamsul Ola ◽  
Puttur D. Prasad ◽  
Amira El-Sherbeny ◽  
Vadivel Ganapathy ◽  
...  

Taurine is actively transported at the retinal pigment epithelial (RPE) apical membrane in an Na+- and Cl−-dependent manner. Diabetes may alter the function of the taurine transporter. Because nitric oxide (NO) is a molecule implicated in the pathogenesis of diabetes, we asked whether NO would alter the activity of the taurine transporter in cultured ARPE-19 cells. The activity of the transporter was stimulated in the presence of the NO donor 3-morpholinosydnonimine. The stimulatory effects of 3-morpholinosydnonimine were not observed during the initial 16-h treatment; however, stimulation of taurine uptake was elevated dramatically above control values with 20- and 24-h treatments. Kinetic analysis revealed that the stimulation was associated with an increase in the maximal velocity of the transporter with no significant change in the substrate affinity. The NO-induced increase in taurine uptake was inhibited by actinomycin D and cycloheximide. RT-PCR analysis and nuclear run-on assays provided evidence for upregulation of the transporter gene. This study provides the first evidence of an increase in taurine transporter gene expression in human RPE cells cultured under conditions of elevated levels of NO.


FEBS Letters ◽  
2003 ◽  
Vol 540 (1-3) ◽  
pp. 71-76 ◽  
Author(s):  
Xiaobin Han ◽  
Russell W Chesney

Genomics ◽  
1995 ◽  
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Amrat Patel ◽  
Julie M. Rochelle ◽  
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Janos Sumegi ◽  
George R. Uhl ◽  
...  

Author(s):  
Xiaobin Han ◽  
Andrea M. Budreau ◽  
Russell W. Chesney ◽  
John A. Sturman

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