Synthesis of conformationally constrained hydroxy-α-amino acids by intramolecular conjugate addition

Amino Acids ◽  
2000 ◽  
Vol 18 (2) ◽  
pp. 117-127 ◽  
Author(s):  
A. Avenoza ◽  
J. H. Busto ◽  
C. Cativiela ◽  
J. M. Peregrina
Keyword(s):  
Amino Acids ◽  
Conjugate Addition ◽  
Conformationally Constrained

scholarly journals Michael Addition of Imidazole to α, β -Unsaturated Carbonyl/Cyano Compound

2018 ◽  
Vol 5 (1) ◽  
pp. 18-31
Author(s):  
Seetaram Mohapatra ◽  
Nilofar Baral ◽  
Nilima Priyadarsini Mishra ◽  
Pravati Panda ◽  
Sabita Nayak
Keyword(s):  
Organic Chemistry ◽  
Amino Acids ◽  
Anticancer Agents ◽  
Michael Addition ◽  
Addition Reaction ◽  
Bond Formation ◽  
Conjugate Addition ◽  
Michael Addition Reaction ◽  
Cyano Compounds ◽  
Nitrogen Bond

Introduction: Aza-Michael addition is an important reaction for carbon-nitrogen bond formation in synthetic organic chemistry. Expalantion: Conjugate addition of imidazole to α,β-unsaturated carbonyl/cyano compounds provides significant numbers of the biologically and synthetically interesting products, such as β-amino acids and β-lactams, which have attracted great attention for their use as key intermediates of anticancer agents, antibiotics and other drugs. Conclusion: This review addresses most significant method for the synthesis of N-substituted imidazole derivatives following Michael addition reaction of imidazole to α,β-unsaturated carbonyl/cyano compounds using ionic liquid/base/acid/enzyme as catalysts from year 2007-2017.

Asymmetric synthesis of cyclic β-amino acids and cyclic amines via sequential diastereoselective conjugate addition and ring closing metathesis

Tetrahedron ◽  
2003 ◽  
Vol 59 (18) ◽  
pp. 3253-3265 ◽  
Author(s):  
Ann M Chippindale ◽  
Stephen G Davies ◽  
Keiji Iwamoto ◽  
Richard M Parkin ◽  
Christian A.P Smethurst ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Conjugate Addition ◽  
Ring Closing Metathesis ◽  
Cyclic Amines

Amino Acid Catalyzed Conjugate Addition of Thiol to Dienone

2013 ◽  
Vol 834-836 ◽  
pp. 450-453
Author(s):  
Han Feng Cui ◽  
Yan Lin ◽  
Hao Fan ◽  
Li De Yu ◽  
Ping Nan Wan
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Room Temperature ◽  
Addition Product ◽  
Conjugate Addition ◽  
Acid Catalyzed

Double conjugate addition of thiols with dienones was catalyzed by amino acids at room temperature in methanol, to afford the corresponding addition product in good to excellent yields.

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