Synthesis, subcellular localization and VP16 interaction of the herpes simplex virus type 2 UL46 gene product

2000 ◽  
Vol 145 (10) ◽  
pp. 2149-2162 ◽  
Author(s):  
K. Kato ◽  
T. Daikoku ◽  
F. Goshima ◽  
H. Kume ◽  
K. Yamaki ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Subcellular Localization ◽  
Gene Product ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus ◽  
Ul46 Gene

The US2 gene product of herpes simplex virus type 2 interacts with cytokeratin 18

2001 ◽  
Vol 146 (11) ◽  
pp. 2201-2209 ◽  
Author(s):  
F. Goshima ◽  
D. Watanabe ◽  
H. Suzuki ◽  
H. Takakuwa ◽  
H. Yamada ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Gene Product ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cytokeratin 18 ◽  
Simplex Virus

Characterization of the UL16 gene product of herpes simplex virus type 2

1998 ◽  
Vol 143 (5) ◽  
pp. 863-880 ◽  
Author(s):  
S. Oshima ◽  
T. Daikoku ◽  
S. Shibata ◽  
H. Yamada ◽  
F. Goshima ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Gene Product ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

Characterization of the UL4 gene product of herpes simplex virus type 2

1998 ◽  
Vol 143 (6) ◽  
pp. 1199-1207 ◽  
Author(s):  
H. Yamada ◽  
Y.-M. Jiang ◽  
S. Oshima ◽  
K. Wada ◽  
F. Goshima ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Gene Product ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

scholarly journals Characterization of the UL55 gene product of herpes simplex virus type 2.

1998 ◽  
Vol 79 (8) ◽  
pp. 1989-1995 ◽  
Author(s):  
H Yamada ◽  
Y Nishiyama ◽  
Y M Jiang ◽  
S Oshima ◽  
Y Yamashita ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Gene Product ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

Subcellular localization of the US3 protein kinase of herpes simplex virus type 2

1998 ◽  
Vol 143 (3) ◽  
pp. 613-622 ◽  
Author(s):  
F. Goshima ◽  
T. Daikoku ◽  
H. Yamada ◽  
S. Oshima ◽  
T. Tsurumi ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Protein Kinase ◽  
Subcellular Localization ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

scholarly journals Characterization of the herpes simplex virus type 2 (HSV-2) US2 gene product and a US2-deficient HSV-2 mutant.

1998 ◽  
Vol 79 (11) ◽  
pp. 2777-2784 ◽  
Author(s):  
Y M Jiang ◽  
K Wada ◽  
S Oshima ◽  
T Daikoku ◽  
Y Nishiyama ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Gene Product ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

scholarly journals Identification and characterization of the UL14 gene product of herpes simplex virus type 2

1999 ◽  
Vol 80 (9) ◽  
pp. 2423-2431 ◽  
Author(s):  
K. Wada ◽  
F. Goshima ◽  
H. Takakuwa ◽  
H. Yamada ◽  
T. Daikoku ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Gene Product ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Scaffolding Protein ◽  
Synthesis Inhibitor ◽  
Simplex Virus

The UL14 gene of herpes simplex virus type 2 (HSV-2) is predicted to encode a 219 amino acid protein with a molecular mass of 23 kDa. In this study, the HSV-2 UL14 gene product has been identified by using a rabbit polyclonal antiserum raised against a recombinant 6×His–UL14 fusion protein expressed in E. coli. The antiserum reacted specifically with 34, 33 and 28 kDa proteins in HSV-2-infected cell lysates and also with a 34 kDa protein produced by in vitro transcription and translation reactions, suggesting that the 34 kDa protein is the primary translation product of the UL14 gene. The protein was synthesized at late times post-infection (p.i.) and was not detectable in the presence of the viral DNA synthesis inhibitor acycloguanosine. Indirect immunofluorescence studies localized the UL14 protein both to the nucleus and to perinuclear regions of the cytoplasm, and the nuclear UL14 protein was found to co-localize with the scaffolding protein ICP35 at 9 h p.i. However, the protein accumulated in a perinuclear region of the cytoplasm at 12 h p.i., while most of the ICP35 protein localized within assemblons in the nucleus. Although no detectable UL14 protein was associated with intracellular capsids isolated in the presence of 0·5 M NaCl, it was detected in purified virions. Furthermore, the UL14 protein expressed alone was detected both in the nucleus and in the cytoplasm at 24 h after transfection, but was mainly localized to the cytoplasm at later times.

scholarly journals Multistep transformation by defined fragments of herpes simplex virus type 2 DNA: oncogenic region and its gene product.

1985 ◽  
Vol 82 (24) ◽  
pp. 8493-8497 ◽  
Author(s):  
Y. Hayashi ◽  
T. Iwasaka ◽  
C. C. Smith ◽  
L. Aurelian ◽  
G. K. Lewis ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Gene Product ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Its Gene ◽  
Simplex Virus
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