Experimental infection of colostrum deprived piglets with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiates PCV2 replication

2000 ◽  
Vol 145 (11) ◽  
pp. 2421-2429 ◽  
Author(s):  
G. M. Allan ◽  
F. McNeilly ◽  
J. Ellis ◽  
S. Krakowka ◽  
B. Meehan ◽  
...  
Keyword(s):  
Experimental Infection ◽  
Porcine Circovirus ◽  
Respiratory Syndrome Virus ◽  
Porcine Circovirus 2 ◽  
Pcv2 Replication

scholarly journals Vaccination with a Porcine Reproductive and Respiratory Syndrome (PRRS) Modified Live Virus Vaccine Followed by Challenge with PRRS Virus and Porcine Circovirus Type 2 (PCV2) Protects against PRRS but Enhances PCV2 Replication and Pathogenesis Compared to Results for Nonvaccinated Cochallenged Controls

2015 ◽  
Vol 22 (12) ◽  
pp. 1244-1254 ◽  
Author(s):  
Megan C. Niederwerder ◽  
Bhupinder Bawa ◽  
Nick V. L. Serão ◽  
Benjamin R. Trible ◽  
Maureen A. Kerrigan ◽  
...  
Keyword(s):  
Average Daily Gain ◽  
Disease Model ◽  
Clinical Signs ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Porcine Circovirus ◽  
Respiratory Syndrome Virus ◽  
Live Virus ◽  
Pcv2 Replication

ABSTRACTCoinfections involving porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) contribute to a group of disease syndromes known as porcine circovirus-associated disease (PCVAD). Presumably, PRRSV infection enhances PCV2 replication as a result of modulation of host immunity. The purpose of this study was to evaluate PCV2 replication and pathogenesis in pigs vaccinated with a PRRS modified live virus (MLV) vaccine and subsequently challenged with a combination of PRRSV and PCV2. During the early postchallenge period, the number of pigs with PRRSV-associated clinical signs was decreased, and average daily gain (ADG) was increased, in the vaccinated group, demonstrating the protective effect of PRRS vaccination. However, during the later postchallenge period, more pigs in the vaccinated group showed increased PCV2 viremia, decreased ADG, increased PCVAD clinical signs, and increased mortality. In this disease model, the early benefits of PRRSV vaccination were outweighed by the later amplification of PCVAD.

scholarly journals Trends in Infection with the Porcine reproductive and respiratory syndrome virus and Porcine circovirus 2 on Three Pig Farms

2003 ◽  
Vol 56 (1) ◽  
pp. 3-6
Author(s):  
Isao SHIBATA ◽  
Yo OKUDA ◽  
Takashi SASAKI ◽  
Shigeto YAZAWA ◽  
Mitsuaki ITAGAKI ◽  
...  
Keyword(s):  
Porcine Circovirus ◽  
Respiratory Syndrome Virus ◽  
Pig Farms ◽  
Porcine Circovirus 2

scholarly journals Efficacy of Simultaneous Intradermal Vaccination of Swine against Porcine Circovirus 2, Porcine Reproductive and Respiratory Syndrome Virus, Mycoplasma hyopneumoniae and Lawsonia intracellularis

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2225
Author(s):  
Jacquelyn Horsington ◽  
Maarten Witvliet ◽  
Antonius A. C. Jacobs ◽  
Ruud P. A. M. Segers
Keyword(s):  
Clinical Signs ◽  
Mycoplasma Hyopneumoniae ◽  
Porcine Circovirus ◽  
Respiratory Syndrome Virus ◽  
Lawsonia Intracellularis ◽  
Intradermal Vaccination ◽  
Combined Application ◽  
Labour Costs ◽  
Porcine Circovirus 2 ◽  
Reduced Time

The combined application of vaccines in swine offers many benefits, including reduced time and labour costs, and improved animal welfare, due to fewer injections and manipulations. This study investigated if simultaneous intradermal vaccinations against porcine circovirus 2, porcine reproductive and respiratory syndrome virus, Mycoplasma hyopneumoniae, and Lawsonia intracellularis, using a specialised needle-free applicator would confer comparable protection against experimental infection compared to the single vaccines. In all cases, the administration of the vaccines together was as efficacious as the administration of the vaccines alone, significantly reducing clinical signs associated with each of the four pathogens.

scholarly journals Experimental Inoculation of Conventional Pigs with Porcine Reproductive and Respiratory Syndrome Virus and Porcine Circovirus 2

2002 ◽  
Vol 76 (7) ◽  
pp. 3232-3239 ◽  
Author(s):  
A. Rovira ◽  
M. Balasch ◽  
J. Segalés ◽  
L. García ◽  
J. Plana-Durán ◽  
...  
Keyword(s):  
Growth Retardation ◽  
Severe Disease ◽  
Postweaning Multisystemic Wasting Syndrome ◽  
Porcine Circovirus ◽  
Respiratory Syndrome Virus ◽  
Lymphoid Tissues ◽  
Severe Respiratory Distress ◽  
Wasting Syndrome ◽  
Porcine Circovirus 2 ◽  
Taqman Pcr

ABSTRACT Postweaning multisystemic wasting syndrome (PMWS) is a disease of nursery and fattening pigs characterized by growth retardation, paleness of the skin, dyspnea, and increased mortality rates. Porcine circovirus 2 (PCV2) has been demonstrated to be the cause of PMWS. However, other factors are needed for full development of the syndrome, and porcine reproductive and respiratory syndrome virus (PRRSV) infection has been suggested to be one of them. Twenty-four conventional 5-week-old pigs were distributed in four groups: control (n = 5), PRRSV inoculated (n = 5), PCV2 inoculated (n = 7), and PRRSV and PCV2 inoculated (n = 7). The two groups inoculated with PRRSV showed growth retardation. Pigs inoculated with both PRRSV and PCV2 had increased rectal temperature. One of these pigs developed wasting, had severe respiratory distress, and died. The most important microscopic lesion in pigs inoculated with PCV2 was lymphocyte depletion with histiocytic infiltration of the lymphoid organs, more severe and in a wider range of tissues in doubly inoculated pigs. Interstitial pneumonia was observed in the three inoculated groups. PCV2 nucleic acid was found by in situ hybridization in larger amounts and in a wider range of lymphoid tissues in PRRSV- and PCV2-inoculated than in PCV2-inoculated pigs. TaqMan PCR was performed to quantify the PCV2 loads in serum during the experiment. PCV2 loads were higher in doubly inoculated pigs than in pigs inoculated with PCV2 alone. These findings indicate that severe disease can be reproduced in conventional 5-week-old pigs by inoculation of PRRSV and PCV2. Moreover, these results support the hypothesis that PRRSV infection enhances PCV2 replication.

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