The nucleotide sequence of the high-leukemogenic murine retrovirus SL3-3 reveals a patch of mink cell focus forming-like sequences upstream of the ecotropic envelope gene

1999 ◽  
Vol 144 (11) ◽  
pp. 2207-2212 ◽  
Author(s):  
A. H. Lund ◽  
F. S. Pedersen
Keyword(s):  
Nucleotide Sequence ◽  
Envelope Gene ◽  
Mink Cell

Generation of AKR mink cell focus-forming virus: Nucleotide sequence of the 3′ end of a somatically acquired AKR-MCF

Virology ◽  
1984 ◽  
Vol 136 (2) ◽  
pp. 425-434 ◽  
Author(s):  
Wim Quint ◽  
Wilbert Boelens ◽  
Peter van Wezenbeek ◽  
Els Robanus Maandag ◽  
Anton Berns
Keyword(s):  
Nucleotide Sequence ◽  
Mink Cell

Nucleotide sequence of the tick-borne, orthomyxo-like Dhori/Indian/1313/61 virus envelope gene

Virology ◽  
1990 ◽  
Vol 175 (1) ◽  
pp. 10-18 ◽  
Author(s):  
Elizabeth Z. Freedman-Faulstich ◽  
Frederick J. Fuller
Keyword(s):  
Nucleotide Sequence ◽  
Envelope Gene ◽  
Virus Envelope

scholarly journals Friend murine leukemia virus-induced leukemia is associated with the formation of mink cell focus-inducing viruses and is blocked in mice expressing endogenous mink cell focus-inducing xenotropic viral envelope genes.

1981 ◽  
Vol 154 (3) ◽  
pp. 907-920 ◽  
Author(s):  
S Ruscetti ◽  
L Davis ◽  
J Feild ◽  
A Oliff
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Viral Envelope ◽  
Envelope Gene ◽  
Related Protein ◽  
Newborn Mice ◽  
Endogenous Expression ◽  
Mink Cell ◽  
Resistant Strains ◽  
Murine Leukemia

In these studies, we have shown data that are consistent with the hypothesis that mink cell focus-inducing viruses (MCF) play an important role in the generation of an erythroproliferative disease developing after injection of certain strains of newborn mice with ecotropic Friend murine leukemia virus (F-MuLV). Resistance to this disease is correlated with the endogenous expression of an MCF/xenotropic virus-gp70-related protein that may interfere with the replication or spread of MCF viruses. These ideas are supported by the following observations: (a) after infection with F-MuLV, only 6/13 strains of mice-developed disease, and studies with crosses between susceptible and resistant strains indicated that resistance was dominant. Although F-MuLV was shown to replicate equally well in all strains tested, viruses coding for MCF-specific viral envelope proteins could be detected only in the spleens of mice from strains that were resistant to F-MuLV-induced disease and not in the spleens of mice from strains that were resistant to F-MuLV-induced disease; (b) a Friend MCF (Fr-MCF) virus isolated from the spleen of an F-MuLV-infected mouse from a susceptible strain induced the same erythroproliferative disease when injected as an appropriate pseudotype into mice from susceptible but not resistant strains of mice; and (c) resistant but not susceptible strains of mice endogenously express MCF/xenotropic virus-related envelope glycoproteins that may be responsible for resistance by blocking receptors for MCF viruses. These results not only indicate that Fr-MCF virus is a crucial intermediate in the induction of disease by F-MuLV, but also suggest that a novel gene, either an MCF/xenotropic virus-related envelope gene or a gene controlling its expression, is responsible for resistance to erythroleukemia induced by F-MuLV.

scholarly journals Type-specific radioimmunoassays for the gp70s of mink cell focus-inducing murine leukemia viruses: expression of a cross-reacting antigen in cells infected with the friend strain of the spleen focus-forming virus

1978 ◽  
Vol 148 (3) ◽  
pp. 654-663 ◽  
Author(s):  
S Ruscetti ◽  
D Linemeyer ◽  
J Feild ◽  
D Troxler ◽  
E Scolnick
Keyword(s):  
Genetic Information ◽  
Recombinant Virus ◽  
Leukemia Virus ◽  
Envelope Gene ◽  
Mink Cell ◽  
Rat Fibroblasts ◽  
Type C ◽  
Leukemia Viruses ◽  
Gene Recombinant ◽  
Murine Leukemia

We have isolated the gp70 of a helper-independent strain of a Friend mink cell focus-inducing (MCF) virus, Fr-MCF-1. This recombinant virus, like the previously described AKR-MCF viruses, has been shown by both biological and biochemical means to be an envelope gene recombinant between Friend murine leukemia virus (F-MuLV) and a mouse xenotropic virus. Utilizing (125)I- labeled Fr-MCF-1 gp70 and antiserum prepared against an MCF strain of Moloney type-C virus (Mol-MCF(83)), we have developed a radioimmunoassay which detects immunological determinant (s)contained in the gp70s of MCF viruses derived from F-MuLV, Mol-MuLV, and AKR-MuLV. This MCF determinant(s) is not detected in the ecotropic parents of each of these MCF viruses, nor in helper-independent murine xenotropic viruses derived from Swiss or BALB/c mice. A protein partially cross-reactive with the MCF gp70 determinant(s) is detected in a replicating xenotropic virus derived from NZB mice. Utilizing this MCF gp70 specific immunoassay, we can detect a cross-reacting gene product coded for by the Friend strain of the spleen focus-forming virus (SFFV) in rat fibroblasts nonproductively infected with SFFV. The results support earlier molecular hybridization studies which indicated that the genome of SFFV contains genetic information derived from both F-MuLV and xenotropic virus, and that the xenotropic-related sequences in SFFV are highly related to those found in MCF murine type-C viruses.

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