Characterization of a bovine herpesvirus 4(BHV-4) 1.1-kb RNA and its transactivation by BHV-4 immediate-early 2 gene product

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Experimental infection with the γ-herpesvirus bovine herpesvirus 4 (BoHV-4) rarely establishes disease, yet BoHV-4 is commonly associated with uterine disease in cattle. Uterine disease involves co-infection with bacteria such asEscherichia coli, which stimulate the production of prostaglandin E2(PGE2) by endometrial cells. BoHV-4 replication depends on immediate early 2 (IE2) gene transactivation and, in the present study, PGE2,E. colior its lipopolysaccharide upregulated theIE2gene promoter in uterine cells. Bacterial co-infection is important for BoHV-4 uterine disease.


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Julieta Manrique ◽  
Pedro Morán ◽  
Florencia Romeo ◽  
Hernán Angelini ◽  
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