Effect of a live attenuated intranasal vaccine on latency and shedding of feline herpesvirus 1 in domestic cats

1997 ◽  
Vol 142 (12) ◽  
pp. 2389-2400 ◽  
Author(s):  
B. J. Weigler ◽  
J. S. Guy ◽  
M. P. Nasisse ◽  
S. I. Hancock ◽  
B. Sherry
Keyword(s):  
Domestic Cats ◽  
Feline Herpesvirus ◽  
Intranasal Vaccine ◽  
Herpesvirus 1

scholarly journals Experimental Infection of Domestic Cats with Feline Herpesvirus-1 Strain CH-B Isolated from British Shorthair Cat

2020 ◽  
Author(s):  
Jiangting Niu ◽  
Han Zhao ◽  
Shuang Zhang ◽  
Yanbing Guo ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Experimental Infection ◽  
Neuronal Cells ◽  
Natural Host ◽  
Upper Respiratory Tract ◽  
Domestic Cats ◽  
Ocular Symptoms ◽  
Feline Herpesvirus ◽  
Upper Respiratory ◽  
Herpesvirus 1

Abstract Background: Feline herpesvirus-1 (FHV-1) is a most common virus that cause viral rhinotracheitis and ocular diseases in domestic cats and wild felids. As other alpha-herpesviruses, acute FHV-1 infection is responsible for severe upper respiratory tract and ocular disease, followed by lifelong latency that persist the limited virus in sensory neuronal cells. While latency reactivation can result in recrudescence, leading sever ocular lesions. Hence, FHV-1 infection in cats can be considered as a good natural host model to study alpha-herpesvirus pathogenesis. Results: In this study, the FHV-1 CH-B was isolated from nasal discharge collected from a British shorthair cat in China, and was further identified via transmission electron microscopy (TEM) observation, indirect immunofluorescence assay (IFA) and genome analysis. Experimental infection of domestic cats with different dose of isolate CH-B, ranging from 104 to 107 TCID50, showed that cats inoculated with 105 TCID50 not only showed typical upper respiratory track and ocular symptoms, but also could copy the progress of disease development. Therefore, the FHV-1 infection model was established by intranasally inoculated with 105 TCID50 of FHV-1 isolate CH-B. Infected cats began to show clinical signs at days 5 post inoculated (dpi), developed severe upper respiratory tract and ocular symptoms at 10-15 dpi, began to recover at 20 dpi, and recovered almost completely by 25 dpi. During acute infection period, virus mainly replicates in turbinate, conjunctiva, cornea and sensory neuronal cells, while virus only persists in trigeminal ganglia (TG) at lifelong latency. Viremia and viral infections in lungs do not appear in FHV-1 CH-B infected cats, with only one exception. We also demonstrate that FHV-1 CH-B infection can induce severe inflammatory responses and lung, trachea, and tonsils tissues damage in cats. In addition, we found that FHV-1 infected cats can shed virus via nasal and ocular discharge, resulting FHV-1 infection in in-contact cats. Conclusions: This natural host model of FHV-1 infection will be valuable for the screen and assessment of antiviral drugs and vaccines, as well as the studies of the pathogenesis of alpha-herpesvirus infection in animals and humans.

Evidence of feline herpesvirus-1 DNA in the vestibular ganglion of domestic cats

2010 ◽  
Vol 184 (3) ◽  
pp. 371-372 ◽  
Author(s):  
Birgit Parzefall ◽  
Wolfgang Schmahl ◽  
Andrea Fischer ◽  
Andreas Blutke ◽  
Uwe Truyen ◽  
...  
Keyword(s):  
Domestic Cats ◽  
Vestibular Ganglion ◽  
Feline Herpesvirus ◽  
Herpesvirus 1

scholarly journals Variable accuracy, precision, and consistency of compounded famciclovir formulated for management of feline herpesvirus‐1 in cats

2021 ◽  
Author(s):  
Louise M. O'Leary ◽  
Rachel A. Allbaugh ◽  
Dwayne E. Schrunk ◽  
Thomas E. Olsen ◽  
Lionel Sebbag
Keyword(s):  
Feline Herpesvirus ◽  
Herpesvirus 1

scholarly journals Ocular and neural distribution of feline herpesvirus-1 during active and latent experimental infection in cats

2013 ◽  
Vol 9 (1) ◽  
pp. 185 ◽  
Author(s):  
Wendy M Townsend ◽  
Susan Jacobi ◽  
Shih-Han Tai ◽  
Matti Kiupel ◽  
Annabel G Wise ◽  
...  
Keyword(s):  
Experimental Infection ◽  
Feline Herpesvirus ◽  
Herpesvirus 1

Feline Herpesvirus-1

2011 ◽  
Vol 13 (5) ◽  
pp. 333-346 ◽  
Author(s):  
David Gould
Keyword(s):  
Feline Herpesvirus ◽  
Herpesvirus 1

Inoculation with Bartonella Henselae Followed by Feline Herpesvirus 1 Fails to Activate Ocular Toxoplasmosis in Chronically Infected Cats

2002 ◽  
Vol 4 (2) ◽  
pp. 107-110 ◽  
Author(s):  
CC Powell ◽  
DL Kordick ◽  
MR Lappin
Keyword(s):  
Experimental Design ◽  
Toxoplasma Gondii ◽  
Anterior Uveitis ◽  
Bartonella Henselae ◽  
Ocular Toxoplasmosis ◽  
Multiple Infections ◽  
Immune Stimulation ◽  
Feline Herpesvirus ◽  
Herpesvirus 1 ◽  
Disease Free

Infection by Toxoplasma gondii is very common in cats although most remain disease free. The factors that trigger development of uveitis in some cats infected with T gondii have not been elucidated, but infection by more than one organism may be contributory. In this study, cats chronically infected with T gondii were inoculated with Bartonella henselae followed by FHV-1 to test the hypothesis that immune stimulation by multiple infections will reactivate ocular toxoplasmosis. Anterior uveitis and chorioretinitis were not detected in the cats with chronic T gondii infection thus allowing rejection of the hypothesis using this experimental design.

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