Initial serotonin transport into viable platelets and imipramine binding to platelet membranes

2002 ◽  
Vol 109 (5-6) ◽  
pp. 547-556 ◽  
Author(s):  
M. L. Rao ◽  
C. Frahnert ◽  
O. Zagorski
Keyword(s):  
Platelet Membranes ◽  
Imipramine Binding ◽  
Serotonin Transport

Chemical heterogeneity of [3H]imipramine binding sites on human platelet membranes

1990 ◽  
Vol 189 (2-3) ◽  
pp. 175-183
Author(s):  
Andrey M. Fomenko ◽  
Yury G. Plyashkevich ◽  
Oleg S. Brusov ◽  
Vladimir P. Demushkin
Keyword(s):  
Binding Sites ◽  
Human Platelet ◽  
Chemical Heterogeneity ◽  
Platelet Membranes ◽  
Imipramine Binding

3H-imipramine binding to freshly prepared platelet membranes in depression

1989 ◽  
Vol 29 (1) ◽  
pp. 87-103 ◽  
Author(s):  
Andreas E. Theodorou ◽  
Cornelius L.E. Katona ◽  
Sharon L. Davies ◽  
Anthony S. Hale ◽  
Sally M. Kerry ◽  
...  
Keyword(s):  
Platelet Membranes ◽  
Imipramine Binding

Is decreased imipramine binding by platelet membranes in major depression associated with plasma autoantibodies to imipramine binding sites?

1990 ◽  
Vol 28 (4) ◽  
pp. 365-368 ◽  
Author(s):  
Iyad Alosachie ◽  
James B. Peter ◽  
Hiroshi Tsuchihashi ◽  
David L. Knight ◽  
Charles B. Nemeroff
Keyword(s):  
Major Depression ◽  
Binding Sites ◽  
Platelet Membranes ◽  
Imipramine Binding

The Uptake of Adenine by Isolated Human Platelet Membranes

1974 ◽  
Vol 32 (02/03) ◽  
pp. 457-464
Author(s):  
Paul C. French ◽  
Jan J. Sixma ◽  
Holm Holmsen
Keyword(s):  
Human Platelet ◽  
Facilitated Diffusion ◽  
Adenine Phosphoribosyltransferase ◽  
Ph Optimum ◽  
Intact Cells ◽  
Platelet Membranes ◽  
Group Translocation ◽  
Triton X

SummaryAdenine uptake into isolated platelet membranes had about the same Km (151 ± 21 • 9 nM) as uptake into intact cells (159 ± 21 nM) and was also competitively inhibited by papaverine and hypoxanthine. No uptake occurred at 0° and accumulated adenine was converted to AMP. AMP was not firmly bound to protein as judged by chromatography of triton X-100 solubilized membranes on Sephadex G25. The pH optimum for adenine uptake was at pH 5-5. Exogenous 5-phosphoribosyl-l-pyrophos- phate strongly stimulated uptake. These data may be explained by uptake of adenine by facilitated diffusion followed by conversion to AMP by adenine phosphoribosyltransferase but group translocation cannot be entirely excluded.

“Active Sites” on Platelet Membranes

1975 ◽  
Vol 34 (03) ◽  
pp. 859-860
Author(s):  
M. G Davey
Keyword(s):  
Active Sites ◽  
Platelet Membranes
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