Granule cell proliferation and axon terminal degradation in the dentate gyrus of gerbils (Meriones unguiculatus) during maturation, adulthood and aging

2000 ◽  
Vol 107 (6) ◽  
pp. 639-647 ◽  
Author(s):  
R. R. Dawirs ◽  
G. Teuchert-Noodt ◽  
K. Hildebrandt ◽  
F. Fei
Keyword(s):  
Cell Proliferation ◽  
Dentate Gyrus ◽  
Granule Cell ◽  
Axon Terminal ◽  
Meriones Unguiculatus

Increased cell proliferation and granule cell number in the dentate gyrus of protein repair-deficient mice

2005 ◽  
Vol 493 (4) ◽  
pp. 524-537 ◽  
Author(s):  
Christine E. Farrar ◽  
Christine S. Huang ◽  
Steven G. Clarke ◽  
Carolyn R. Houser
Keyword(s):  
Cell Proliferation ◽  
Dentate Gyrus ◽  
Granule Cell ◽  
Cell Number ◽  
Protein Repair ◽  
Deficient Mice

scholarly journals Post-Stroke Social Isolation Reduces Cell Proliferation in the Dentate Gyrus and Alters miRNA Profiles in the Aged Female Mice Brain

2020 ◽  
Vol 22 (1) ◽  
pp. 99
Author(s):  
Aleah Holmes ◽  
Yan Xu ◽  
Juneyoung Lee ◽  
Michael E. Maniskas ◽  
Liang Zhu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Dentate Gyrus ◽  
Social Isolation ◽  
Census Data ◽  
Elderly Women ◽  
Stroke Recovery ◽  
Tissue Loss ◽  
Female Mice ◽  
Post Stroke ◽  
The Brain

Social isolation and loneliness are risk factors for stroke. Elderly women are more likely to be isolated. Census data shows that in homeowners over the age of 65, women are much more likely to live alone. However, the underlying mechanisms of the detrimental effects of isolation have not been well studied in older females. In this study, we hypothesized that isolation impairs post-stroke recovery in aged female mice, leading to dysregulated microRNAs (miRNAs) in the brain, including those previously shown to be involved in response to social isolation (SI). Aged C57BL/6 female mice were subjected to a 60-min middle cerebral artery occlusion and were randomly assigned to either single housing (SI) or continued pair housing (PH) immediately after stroke for 15 days. SI immediately after stroke led to significantly more brain tissue loss after stroke and higher mortality. Furthermore, SI significantly delayed motor and sensory recovery and worsened cognitive function, compared to PH. A decrease in cell proliferation was seen in the dentate gyrus of SI mice assessed by bromodeoxyuridine (BrdU) labeling. miRNAome data analysis revealed changes in several miRNAs in the brain, such as miR-297a-3p and miR-200c-3p, which are known to regulate pathways involved in cell proliferation. In conclusion, our data suggest that SI can lead to a poor post-stroke recovery in aged females and dysregulation of miRNAs and reduced hippocampal cell proliferation.

Age-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats

2004 ◽  
Vol 355 (1-2) ◽  
pp. 152-154 ◽  
Author(s):  
Young-Pyo Kim ◽  
Hong Kim ◽  
Mal-Soon Shin ◽  
Hyun-Kyung Chang ◽  
Mi-Hyeon Jang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Dentate Gyrus ◽  
Treadmill Exercise ◽  
Age Dependence

scholarly journals Cell Proliferation and Granule Cell Dispersion in Human Hippocampal Sclerosis

2005 ◽  
Vol 64 (3) ◽  
pp. 194-201 ◽  
Author(s):  
Maria Thom ◽  
Lillian Martinian ◽  
Gareth Williams ◽  
Kai Stoeber ◽  
Sanjay M. Sisodiya
Keyword(s):  
Cell Proliferation ◽  
Granule Cell ◽  
Hippocampal Sclerosis ◽  
Cell Dispersion

The Effect of Swimming on Cell Proliferation in the Hippocampal Dentate Gyrus of Rats

2004 ◽  
Vol 21 ◽  
pp. 621-630
Author(s):  
Baek Vin Lim ◽  
Jin Kook Park ◽  
Myoung Jei Chang ◽  
Mal Soon Shin ◽  
Chang Ju Kim
Keyword(s):  
Cell Proliferation ◽  
Dentate Gyrus ◽  
Hippocampal Dentate Gyrus

Role of Pax6 in development of the cerebellar system

Development ◽  
1999 ◽  
Vol 126 (16) ◽  
pp. 3585-3596 ◽  
Author(s):  
D. Engelkamp ◽  
P. Rashbass ◽  
A. Seawright ◽  
V. van Heyningen
Keyword(s):  
Cell Proliferation ◽  
Cell Migration ◽  
Granule Cell ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Long Distance ◽  
Cerebellar Granule ◽  
Precerebellar Nuclei ◽  
Rhombic Lip

Post-mitotic neurons generated at the rhombic lip undertake long distance migration to widely dispersed destinations, giving rise to cerebellar granule cells and the precerebellar nuclei. Here we show that Pax6, a key regulator in CNS and eye development, is strongly expressed in rhombic lip and in cells migrating away from it. Development of some structures derived from these cells is severely affected in Pax6-null Small eye (Pax6(Sey)/Pax6(Sey)) embryos. Cell proliferation and initial differentiation seem unaffected, but cell migration and neurite extension are disrupted in mutant embryos. Three of the five precerebellar nuclei fail to form correctly. In the cerebellum the pre-migratory granule cell sub-layer and fissures are absent. Some granule cells are found in ectopic positions in the inferior colliculus which may result from the complete absence of Unc5h3 expression in Pax6(Sey)/Pax6(Sey) granule cells. Our results suggest that Pax6 plays a strong role during hindbrain migration processes and at least part of its activity is mediated through regulation of the netrin receptor Unc5h3.

scholarly journals LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance

Neuron ◽  
2017 ◽  
Vol 95 (4) ◽  
pp. 928-943.e3 ◽  
Author(s):  
Yuki Hashimotodani ◽  
Kaoutsar Nasrallah ◽  
Kyle R. Jensen ◽  
Andrés E. Chávez ◽  
Daniel Carrera ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Granule Cell ◽  
Dentate Granule Cell ◽  
Mossy Cell
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