Cerebrospinal fluid levels of alpha-tocopherol in amyotrophic lateral sclerosis

1998 ◽  
Vol 105 (6-7) ◽  
pp. 703-708 ◽  
Author(s):  
F. de Bustos ◽  
F. J. Jiménez-Jiménez ◽  
J. A. Molina ◽  
J. Esteban ◽  
A. Guerrero-Sola ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cerebrospinal Fluid ◽  
Alpha Tocopherol ◽  
Cerebrospinal Fluid Levels ◽  
Fluid Levels ◽  
Lateral Sclerosis

Cerebrospinal fluid levels of chromogranin A and phosphorylated neurofilament heavy chain are elevated in amyotrophic lateral sclerosis

2017 ◽  
Vol 136 (4) ◽  
pp. 360-364 ◽  
Author(s):  
M. Kaiserova ◽  
Z. Grambalova ◽  
P. Otruba ◽  
D. Stejskal ◽  
H. Prikrylova Vranova ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cerebrospinal Fluid ◽  
Heavy Chain ◽  
Chromogranin A ◽  
Cerebrospinal Fluid Levels ◽  
Fluid Levels ◽  
Lateral Sclerosis

Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis

1999 ◽  
Vol 106 (9-10) ◽  
pp. 943-948 ◽  
Author(s):  
T. Matsuishi ◽  
S. Nagamitsu ◽  
H. Shoji ◽  
M. Itoh ◽  
S. Takashima ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cerebrospinal Fluid ◽  
Substance P ◽  
Cerebrospinal Fluid Levels ◽  
Fluid Levels ◽  
Lateral Sclerosis

scholarly journals YKL40 in sporadic amyotrophic lateral sclerosis: cerebrospinal fluid levels as a prognosis marker of disease progression

Aging ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 2367-2382 ◽  
Author(s):  
Pol Andrés-Benito ◽  
Raúl Domínguez ◽  
Maria J. Colomina ◽  
Franc Llorens ◽  
Mònica Povedano ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cerebrospinal Fluid ◽  
Disease Progression ◽  
Sporadic Amyotrophic Lateral Sclerosis ◽  
Cerebrospinal Fluid Levels ◽  
Prognosis Marker ◽  
Fluid Levels ◽  
Lateral Sclerosis

Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Alzheimer's disease

1997 ◽  
Vol 104 (6-7) ◽  
pp. 703-710 ◽  
Author(s):  
F. J. Jiménez-Jiménez ◽  
F. de Bustos ◽  
J. A. Molina ◽  
J. Benito-León ◽  
A. Tallón-Barranco ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Vitamin E ◽  
Alpha Tocopherol ◽  
Cerebrospinal Fluid Levels ◽  
Fluid Levels

Cerebrospinal fluid levels of alpha-tocopherol in patients with multiple sclerosis

1998 ◽  
Vol 249 (1) ◽  
pp. 65-67 ◽  
Author(s):  
Felix Javier Jiménez-Jiménez ◽  
Fernando de Bustos ◽  
José Antonio Molina ◽  
Clara de Andrés ◽  
Teresa Gasalla ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Alpha Tocopherol ◽  
Cerebrospinal Fluid Levels ◽  
Fluid Levels

Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Parkinson's disease

1997 ◽  
Vol 104 (11-12) ◽  
pp. 1287-1293 ◽  
Author(s):  
J. A. Molina ◽  
F. de Bustos ◽  
F. J. Jiménez-Jiménez ◽  
J. Benito-León ◽  
M. Ortí-Pareja ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Vitamin E ◽  
Alpha Tocopherol ◽  
Cerebrospinal Fluid Levels ◽  
Fluid Levels

scholarly journals Increased cerebrospinal fluid adenosine 5'-triphosphate in patients with amyotrophic lateral sclerosis

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Takamasa Nukui ◽  
Atsushi Matsui ◽  
Hideki Niimi ◽  
Tomoyuki Sugimoto ◽  
Tomohiro Hayashi ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cerebrospinal Fluid ◽  
Serum Creatinine ◽  
Disease Severity ◽  
Assay System ◽  
Atp Levels ◽  
Sum Score ◽  
Highly Sensitive ◽  
Severe Group ◽  
Lateral Sclerosis

Abstract Background Extracellular adenosine 5'-triphosphate (ATP) has been suggested to cause neuroinflammation and motor neuron degeneration by activating microglia and astrocytes in amyotrophic lateral sclerosis (ALS). Since we have developed a highly sensitive ATP assay system, we examined cerebrospinal fluid (CSF) ATP levels in patients with ALS whether it can be a useful biomarker in ALS. Methods Forty-eight CSF samples from 44 patients with ALS were assayed for ATP with a newly established, highly sensitive assay system using luciferase luminous reaction. CSF samples from patients with idiopathic normal pressure hydrocephalus (iNPH) were assayed as a control. Patients were divided into two groups depending on their disease severity, as evaluated using the Medical Research Council (MRC) sum score. Correlations between the CSF ATP levels and other factors, including clinical data and serum creatinine levels, were evaluated. Results CSF ATP levels were significantly higher in patients with ALS than in the iNPH (716 ± 411 vs. 3635 ± 5465 pmol/L, p < 0.01). CSF ATP levels were significantly higher in the more severe group than in the iNPH group (6860 ± 8312 vs. 716 ± 411 pmol/L, p < 0.05) and mild group (6860 ± 8312 vs. 2676 ± 3959 pmol/L, p < 0.05) respectively. ALS functional rating scale-revised (ALSFRS-R) (37.9 ± 5.7 vs. 42.4 ± 2.8, p < 0.01) and serum creatinine levels (0.51 ± 0.13 vs. 0.68 ± 0.23 mg/dL, p < 0.05) were significantly lower in the severe group than in the mild group respectively. A negative correlation of CSF ATP levels with MRC sum score was demonstrated in the correlation analysis adjusted for age and sex (r = -0.3, p = 0.08). Conclusions Extracellular ATP is particularly increased in the CSF of patients with advanced ALS. CSF ATP levels may be a useful biomarker for evaluating disease severity in patients with ALS.

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