Animal Model for Cerebral Arteriovenous Malformation

2000 ◽  
Vol 142 (11) ◽  
pp. 1231-1240 ◽  
Author(s):  
T. A. Pietilä ◽  
J. M. Zabramski ◽  
A. Thèllier-Janko ◽  
K. Duveneck ◽  
W. D. Bichard ◽  
...  
Keyword(s):  
Animal Model ◽  
Arteriovenous Malformation ◽  
Cerebral Arteriovenous Malformation

Surgery for Cerebral Arteriovenous Malformation

2015 ◽  
Vol 76 (S 02) ◽  
Author(s):  
Yoko Kato ◽  
Yasuhiro Yamada ◽  
Kei Yamashiro ◽  
Tsukasa Kawase
Keyword(s):  
Arteriovenous Malformation ◽  
Cerebral Arteriovenous Malformation

Thrombospondin-1 Modulates the Angiogenic Phenotype of Human Cerebral Arteriovenous Malformation Endothelial Cells

Neurosurgery ◽  
2011 ◽  
Vol 68 (5) ◽  
pp. 1342-1353 ◽  
Author(s):  
Christopher J. Stapleton ◽  
Don L. Armstrong ◽  
Raphael Zidovetzki ◽  
Charles Y. Liu ◽  
Steven L. Giannotta ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Arteriovenous Malformation ◽  
Immunosorbent Assay ◽  
Cerebral Arteriovenous Malformation ◽  
Enzyme Linked Immunosorbent Assay ◽  
Boyden Chamber ◽  
Mrna Levels ◽  
Tubule Formation ◽  
Thrombospondin 1 ◽  
And Migration

Abstract BACKGROUND: The management of cerebral arteriovenous malformation (AVM) is challenging, and invasive therapies place vital intracranial structures at risk of injury. The development of noninvasive, pharmacologic approaches relies on identifying factors that mediate key angiogenic processes. Previous studies indicate that endothelial cells (ECs) derived from cerebral AVM (AVM-ECs) are distinct from control brain ECs with regard to important angiogenic characteristics. OBJECTIVE: To determine whether thrombospondin-1 (TSP-1), a potent angiostatic factor, regulates critical angiogenic features of AVM-ECs and to identify factors that modulate TSP-1 production in AVM-ECs. METHODS: EC proliferation, migration, and tubule formation were evaluated with bromodeoxyuridine incorporation, Boyden chamber, and Matrigel studies, respectively. TSP-1 and inhibitor of DNA binding/differentiation 1 (Id1) mRNA levels were quantified with microarray and quantitative real-time polymerase chain reaction analyses. TSP-1 protein expression was measured using Western blotting, immunohistochemical, and enzyme-linked immunosorbent assay techniques. The mechanistic link between Id1 and TSP-1 was established through small interfering RNA-mediated knockdown of Id1 in AVM-ECs followed by Western blot and enzyme-linked immunosorbent assay experiments assessing TSP-1 production. RESULTS: AVM-ECs proliferate faster, migrate more quickly, and form disorganized tubules compared with brain ECs. TSP-1 is significantly down-regulated in AVM-ECs. The addition of TSP-1 to AVM-EC cultures normalizes the rate of proliferation and migration and the efficiency of tubule formation, whereas brain ECs are unaffected. Id1 negatively regulates TSP-1 expression in AVM-ECs. CONCLUSION: These data highlight a novel role for TSP-1 in the pathobiology of AVM angiogenesis and provide a context for its use in the clinical management of brain AVMs.

scholarly journals Elevated end-diastolic ratio of the common carotid artery due to cerebral arteriovenous malformation: Two case reports

2018 ◽  
Vol 13 (4) ◽  
pp. 917-920
Author(s):  
Koji Tanaka ◽  
Shoji Matsumoto ◽  
Takeshi Yamada ◽  
Daisuke Kondo ◽  
Hideo Chihara ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Arteriovenous Malformation ◽  
Common Carotid Artery ◽  
Case Reports ◽  
Cerebral Arteriovenous Malformation ◽  
The Common

scholarly journals Anomalous Internal Carotid Artery Associated With Ipsilateral Cerebral Arteriovenous Malformation. Case Report.

2001 ◽  
Vol 41 (12) ◽  
pp. 607-610 ◽  
Author(s):  
Shinji FUKUI ◽  
Hiroshi KATOH ◽  
Hiroshi NAWASHIRO ◽  
Hidetoshi OOIGAWA ◽  
Tatsumi KAJI ◽  
...  
Keyword(s):  
Case Report ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Arteriovenous Malformation ◽  
Internal Carotid ◽  
Cerebral Arteriovenous Malformation
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