Protective Effects of Memantine Against Ischemia-Reperfusion Injury in Spontaneously Hypertensive Rats

1999 ◽  
Vol 141 (10) ◽  
pp. 1107-1113 ◽  
Author(s):  
A. Dogan ◽  
M. A. Eras ◽  
V. L. Raghavendra Rao ◽  
R. J. Dempsey
Keyword(s):  
Reperfusion Injury ◽  
Spontaneously Hypertensive Rats ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Protective Effects ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury

2020 ◽  
pp. 21-30
Author(s):  
Milan Ivanov ◽  
◽  
Predrag Brkic ◽  
Una-Jovana Vajic ◽  
Nevena Mihailovic-Stanojevic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reperfusion Injury ◽  
Kidney Function ◽  
Spontaneously Hypertensive Rats ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Hemodynamics ◽  
Pure Oxygen ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Background: Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event that can lead to unacceptably high morbidity and mortality. Hyperbaric oxygen (HBO2) preconditioning has been shown to prevent ischemia-reperfusion injury (IRI) in different tissues. Objectives: The aim of our study was to compare the effects of HBO2 preconditioning on renal hemodynamics, kidney function and oxidative stress in normotensive and spontaneously hypertensive rats that suffered kidney IRI. Methods: An experiment was performed on Wistar (normotensive) and spontaneously hypertensive rats (SHR). The animals were divided into the following experimental groups: sham-operated rats and rats with or without HBO2 preconditioning 24 hours before post-ischemic AKI induction. Treated rats were placed into experimental HBO2 chambers and exposed to pure oxygen twice a day for two consecutive days (2.026 bar of oxygen) for 60 minutes. AKI was performed the next morning. The right kidney was removed and the renal ischemia was performed by clamping the left renal artery for 45 minutes. Results: In this study, HBO2 preconditioning significantly improved disturbed renal hemodynamics, major markers of kidney function in plasma (creatinine, urea and phosphate) as well as antioxidant enzymes (superoxide dismutase and catalase) activities in erythrocytes after AKI induction. Also, HBO2 preconditioning decreased lipid peroxidation in plasma after ischemic AKI. Positive effects were observed in both strains of rats. Conclusions: Our results suggest that HBO2 treatment improves renal hemodynamic and kidney function and decreases oxidative stress of Wistar and SHR rats with an AKI episode. Furthermore, it also implies that pre-existing hypertension does not affect the beneficial effects of HBO2 preconditioning.

scholarly journals Tolerance to acute ischemia in adult male and female spontaneously hypertensive rats

2007 ◽  
pp. 267-274 ◽  
Author(s):  
J Bešík ◽  
O Szarszoi ◽  
J Kuneš ◽  
I Netuka ◽  
J Malý ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Reperfusion Injury ◽  
Spontaneously Hypertensive Rats ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Left Ventricular ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Wky Rats ◽  
Developed Pressure

Clinical and experimental studies have repeatedly indicated that overloaded hearts have a higher vulnerability to ischemia/reperfusion injury. The aim of the present study was to answer the question whether the degree of tolerance to oxygen deprivation in hearts of spontaneously hypertensive rats (SHR) may be sex-dependent. For this purpose, adult SHR and their normotensive control Wistar Kyoto (WKY) rats were used. The isolated hearts were perfused according to Langendorff at constant pressure (proportionally adjusted to the blood pressure in vivo). Recovery of contractile parameters (left ventricular systolic, diastolic and developed pressure as well as the peak rate of developed pressure) was measured during reperfusion after 20 min of global no-flow ischemia in 5 min intervals. Mean arterial blood pressure was measured by direct puncture of carotid artery under light ether anesthesia in a separate group of animals. The degree of hypertension was comparable in both sexes of SHR. The recovery of contractile functions in SHR males and females was significantly lower than in WKY rats during the whole investigated period. There was no sex difference in the recovery of WKY animals; on the other hand, the recovery was significantly better in SHR females than in SHR males. It may be concluded that the hearts of female SHR are more resistant to ischemia/reperfusion injury as compared with male SHR. This fact could have important clinical implications for the treatment of cardiovascular disease in women.

Possible Protective Effects of Stem Cells Treatment on Ischemic/Reperfused Hearts in Hypertensive Rats Model

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Gehane M Hamed ◽  
Manal S Abd-El Hamid ◽  
Einas M Nagib ◽  
Hanaa Ahmed Amer ◽  
Nahla Mohamed Hussien
Keyword(s):  
Stem Cells ◽  
Body Weight ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Treated Group ◽  
Atherogenic Index ◽  
Protective Effects ◽  
Hypertensive Rats ◽  
Cardiac Tissues

Abstract Back Ground Hypertension and its cardiovascular complications as myocardial infarction are the leading causes of morbidity and mortality worldwide. Reperfusion strategies are the current standard therapy but they result in cardiac ischemia reperfusion injury. Stem cell transplantation has emerged as a promising therapeutic strategy and showed many beneficial effects in different medical disorders as reno-vascular hypertension. Aim of Work To assess the possible protective effects of bone marrow derived mesemchymal stem cells treatment on ischemic/reperfused hearts in hypertensive rats. Materials & Methods 49 adult female Wistar albino rats, were allocated into three main groups: control group, hypertensive untreated (Ht-u) group and hypertensive stem cells (Ht-SCs) treated group. Body weight, arterial blood pressure, ECG recording, isolated heart study with exposure to ischemia reperfusion injury and fluorescence imaging of labeled MSCs in the heart, aorta and liver were performed. Plasma lipid profile, nitric oxide, MDA and SOD levels and cardiac MDA and SOD levels were estimated. Cardiac tissues were weighed. Heart, aorta and liver were histopathologically assessed. Results Ht-SCs treated group demonstrated significant increase in body weight gain %, significant decrease in R voltage, SBP, DBP and MAP sixth week values compared to HT-u group, with DBP and MAP showing non-significance from the control. Significant increase in heart rate basal and all reperfusion values and non-significant increase in basal PT/LVW were detected compared to HT-u group. Basal TPT and HRT were significantly shortened and MFR/LVW was significantly increased than HT-u group, being non-significantly changed from the control denoting systolic and diastolic function improvement.TPT and HRT prolongation and MFR/LVW decrease after IR injury was significantly lower in HT-SC group than HT-u group. This was accompanied by significant decrease in atherogenic index, plasma and cardiac MDA and significant increase in plasma nitrites, SOD and cardiac SOD. BM-MScs were detected in cardiac and aortic tissues. Conclusion Single injection of BM-MScs exerted anti-hypertensive and anti-hypertrophic effects, reduced systolic and diastolic dysfunction after ischemia reperfusion injury and improved coronary flow in hypertensive rats, through homing into aortic tissues mitigating endothelial dysfunction and exerting angiogenic effects and homing into cardiac tissues exerting anti-oxidant, anti-inflammatory and anti-apoptotic effects.

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