Proliferative Potential of Recurrent Intracranial Meningiomas as Evaluated by Labelling Indices of BUdR and Ki-67, and Tumour Doubling Time

1998 ◽  
Vol 140 (1) ◽  
pp. 26-32 ◽  
Author(s):  
K. Kakinuma ◽  
R. Tanaka ◽  
K. Onda ◽  
H. Takahashi
Keyword(s):  
Doubling Time ◽  
Proliferative Potential ◽  
Ki 67 ◽  
Intracranial Meningiomas ◽  
Tumour Doubling Time

Evaluation of the Proliferative Potential of Gliomas by KI 67 Immunolabelling of Stereotactic Biopsy Samples

1991 ◽  
pp. 109-111
Author(s):  
M. Parent ◽  
S. Blond ◽  
P. Gosset ◽  
F. Dubois ◽  
R. Assaker ◽  
...  
Keyword(s):  
Stereotactic Biopsy ◽  
Proliferative Potential ◽  
Ki 67

Evaluation of epithelial proliferation in paediatric and adult cholesteatomas using the Ki-67 proliferation marker

2011 ◽  
Vol 126 (5) ◽  
pp. 460-463 ◽  
Author(s):  
K Sikka ◽  
S C Sharma ◽  
A Thakar ◽  
S Dattagupta
Keyword(s):  
Bone Erosion ◽  
Disease Spread ◽  
Histological Evaluation ◽  
Proliferation Index ◽  
Control Group ◽  
Proliferative Potential ◽  
Proliferation Marker ◽  
Epithelial Proliferation ◽  
Ki 67 ◽  
Surgical Specimen

AbstractIntroduction:The aggressiveness of cholesteatoma in children compared with adults is well known. However, the factors influencing the poorer prognosis of paediatric cholesteatoma are not well understood. This study compared the proliferative potential of paediatric cholesteatoma with that of adult cholesteatoma, using Ki-67 as a proliferation marker.Methods:A prospective study of 67 patients with aural cholesteatoma was performed. Thirty-eight adult and 29 paediatric cases were evaluated using clinical parameters including bone erosion, complications and extent of disease. A surgical specimen underwent histological evaluation and measurement of the proliferation index using Ki-67 labelling. Normal epithelium from a control group was also examined.Results:Cholesteatoma epithelium has a greater rate of proliferation than normal skin. There were however no statistical differences between the paediatric and adult cholesteatoma groups in terms of clinical behaviour or proliferation potential. Paediatric cholesteatoma was similar to adult cholesteatoma in terms of complications, bone erosion and disease spread.Conclusion:Cholesteatoma is a disorder of epithelial proliferation. Although postulated to be more aggressive in children than adults, this study found no clinicopathological differences between paediatric and adult cases.

Potential doubling time and tumour doubling time in meningiomas and neurinomas

1996 ◽  
Vol 138 (6) ◽  
pp. 763-770 ◽  
Author(s):  
S. Nakasu ◽  
Y. Nakasu ◽  
M. Nakajima ◽  
M. Yokoyama ◽  
M. Matsuda ◽  
...  
Keyword(s):  
Doubling Time ◽  
Potential Doubling Time ◽  
Tumour Doubling Time ◽  
Potential Doubling

Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: relationships and prognostic value

1997 ◽  
Vol 86 (1) ◽  
pp. 121-130 ◽  
Author(s):  
Julie M. Cunningham ◽  
David W. Kimmel ◽  
Bernd W. Scheithauer ◽  
Judith R. O'Fallon ◽  
Paul J. Novotny
Keyword(s):  
Univariate Analysis ◽  
Tumor Grade ◽  
Nuclear Antigen ◽  
Clinicopathological Parameters ◽  
Proliferative Potential ◽  
Ki 67 ◽  
Proliferation Markers ◽  
P53 Expression ◽  
Content Type ◽  
Mib 1

✓ Consecutive paraffin sections of 105 astrocytomas and 15 oligoastrocytomas were examined for expression of p53, MIB-1 (Ki-67), and proliferating cell nuclear antigen (PCNA). The tumors had been examined previously for genetic abnormalities and by flow cytometry. Regardless of the tumor's stage and grade and the patient's age and gender, p53 expression was found in 40% of tumors. Although p53 expression was associated with a loss on chromosome 17p and was more frequent in aneuploid tumors, it had no association with survival time. The MIB-1 and PCNA labeling indices increased with increasing tumor grade but showed no association with other clinicopathological parameters. In individual tumors, there was poor concordance between any of the variables (MIB-1, PCNA, and p53). Results for p53 and MIB-1 were similar for both astrocytomas and oligoastrocytomas. The MIB-1 and PCNA values appeared to have prognostic utility in univariate analysis but not after adjusting for patient age and tumor grade. The poor concordance between MIB-1 and PCNA in individual tumors indicates that any one means of assessing proliferative potential in gliomas may not be reliable.

scholarly journals Immunohistochemical expression of ki-67 in odontogenic keratocyst: Evidence of aggressive behavior.

2020 ◽  
Vol 27 (01) ◽  
pp. 74-79
Author(s):  
Rabiya Saif ◽  
Hafiz Majid Jehangir ◽  
Abdul Hannan Nagi ◽  
Nadia Naseem ◽  
Zainab Rizvi ◽  
...  
Keyword(s):  
Aggressive Behavior ◽  
Descriptive Study ◽  
World Health ◽  
Odontogenic Keratocyst ◽  
High Recurrence Rate ◽  
Odontogenic Cysts ◽  
P Value ◽  
Proliferative Potential ◽  
Nuclear Staining ◽  
Ki 67

The odontogenic keratocyst (OKC) well-known for its aggressiveness and high recurrence rate, comprises approximately 11% of all jaw cysts. Due to its aggressive behavior it was placed into category of tumour in 2005 by the World Health Organization (WHO). Objectives: The purpose of this study was to determine the Ki-67 expression in Odontogenic Keratocysts to predict its proliferative potential. Study Design: Descriptive study. Setting: Department of Morbid Anatomy and Histopathology, UHS. Periods: June 2014- June 2018. Material & Methods: This is a descriptive study comprising of 39 cases of odontogenic cysts. These surgically removed samples were processed at University of Health Sciences (UHS) laboratory. Routine staining with Hematoxylin & Eosin stain along with immunohistochemistry (IHC) with Ki-67 antibody was performed. Immunohisto chemical scoring was done on the basis of percentage of the nuclear staining of Ki-67. Data was entered into SPSS 22 and descriptive statistics were measured in the form of percentage and frequency. Quantitative variables such as age of patient, size of the cyst, and Ki-67 score were also measured. P value <0.05 was taken as significant. Results: The mean age of the patients was 25.08 ±14.5 years. Significant association was observed between histological variables with odontogenic keratocyst such as parakeratinized epithelial lining (p = 0.00), epithelial hyperplasia both typical and atypical (p = 0.02) and focal spongiosis (p = 0.04). Foci having epithelial atypia demonstrated stronger staining intensity compared to adjacent normal epithelium. However, no significant association was observed between the histological variables and Ki-67 expression. Conclusion: OKC expressed low Ki-67 expression in most of the cases, however, foci of strong expression were also observed in few cases.

scholarly journals Expression of p16 (INK4a), cytokeratin 19, and Ki-67 in canine laryngeal squamous cell carcinoma

2013 ◽  
Vol 57 (3) ◽  
pp. 399-405 ◽  
Author(s):  
Małgorzata Kandefer-Gola ◽  
Rafał Ciaputa ◽  
Marcin Nowak ◽  
Janusz A. Madej
Keyword(s):  
Squamous Cell ◽  
Primary Tumour ◽  
Cytokeratin 19 ◽  
Proliferative Potential ◽  
Ki 67 ◽  
Tissue Sections ◽  
Classical Technique ◽  
Laryngeal Tumours ◽  
P16 Ink4a ◽  
Immunohistochemical Studies

Abstract The study aimed at morphological and immunohistochemical characteristics of laryngeal squamous cell carcinomas and their metastases in canine lymph nodes and lungs. Tissue sections were stained using classical technique with haematoxylin and eosin. In addition, immunohistochemical studies were performed with p16, cytokeratin, and Ki-67 antibodies. An expression of all examined antigens was detected in laryngeal tumours, while in tumour metastases only expression of p16 protein and cytokeratin was demonstrated. The results pointed to higher proliferative potential of the primary tumour than of their metastases.

Pulmonary metastases

2020 ◽  
pp. 4360-4361
Author(s):  
S.G. Spiro
Keyword(s):  
Doubling Time ◽  
Pulmonary Metastases ◽  
Lung Metastases ◽  
Primary Tumour ◽  
Performance Status ◽  
Ct Guided ◽  
Ct Guided Biopsy ◽  
Male Sex ◽  
Tumour Doubling Time ◽  
Suspicious Lesions

Malignant metastasis to the lung is common. It may present as a solitary enlarging nodule, as multiple nodules ranging enormously in size and number, and/or with diffuse lymphatic involvement. Diagnosis can usually be secured by percutaneous CT-guided biopsy and most suspicious lesions will be PET positive. Resection remains the treatment of choice, and good prognostic factors include the time from treatment of the primary tumour to the development of lung metastases, the fewer the number, the absence of extrapulmonary metastases, and the longer the tumour doubling time. The most favourable group are younger patients with a good performance status, with sarcomas who present with lesions a year or more after successful treatment of the primary disease. Factors including older age, male sex, and more lung metastases predict poorer survival after resection of any initial pulmonary metastases.

Proliferative Potential of Sporadic and Neurofibromatosis 2-Associated Schwannomas as Studied by MIB-1 (Ki-67) and PCNA Labeling

1995 ◽  
Vol 54 (6) ◽  
pp. 776-782 ◽  
Author(s):  
Jussi Antinheimo ◽  
Hannu Haapasalo ◽  
Matti Seppälä ◽  
Markku Sainio ◽  
Olli Carpen ◽  
...  
Keyword(s):  
Proliferative Potential ◽  
Neurofibromatosis 2 ◽  
Ki 67 ◽  
Mib 1
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