Quantitative determination of memantine in human plasma by GC using negative ion chemical ionization MS detection after derivatization with a new reagent, o-(pentafluorobenzyloxycarbonyl)-2,3,4,5-tetrafluorobenzoyl chloride

2012 ◽  
Vol 179 (3-4) ◽  
pp. 249-255 ◽  
Author(s):  
Hans J. Leis ◽  
Werner Windischhofer
Keyword(s):  
Quantitative Determination ◽  
Human Plasma ◽  
Chemical Ionization ◽  
Negative Ion ◽  
Ms Detection ◽  
Negative Ion Chemical Ionization

Determination of 3,3'-Dichlorobenzidine in Industrial Wastewaters

2004 ◽  
Vol 39 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Hing-Biu Lee ◽  
Thomas E. Peart ◽  
Ken Terry ◽  
James Maguire
Keyword(s):  
Electron Impact ◽  
Chemical Ionization ◽  
Solid Phase ◽  
Negative Ion ◽  
Gas Chromatography Mass Spectrometry ◽  
Ms Detection ◽  
Negative Ion Chemical Ionization ◽  
Ionization Mode ◽  
Wastewater Samples

Abstract A solid-phase extraction, chemical derivatization, and gas chromatography/mass spectrometry (GC/MS) method has been developed for the determination of trace 3,3'-dichlorobenzidine (DCB) in industrial wastewater samples. Instead of an octadecylsilane (ODS) cartridge, a Porapak RDX cartridge was used since the latter could be optimized for the extraction of DCB. After the pre-concentration, interfering coextractives in the sample were selectively removed from the cartridge by elution with a 1:1 mixture of acetonitrile and water. DCB was then eluted with acetonitrile and derivatized with pentafluoropropionic acid anhydride. The product was subsequently analyzed by GC/MS in either the electron impact or negative ion chemical ionization mode. Recoveries of DCB and the surrogate, DCB-d6, were better than 90% at spiking levels of 10, 1, and 0.1 µg/L. Based on a concentration factor of 100, the detection limits for DCB in wastewater samples were determined to be 0.1 µg/L by electron impact GC/MS detection, and 0.01 µg/L by negative ion chemical ionization GC/MS detection, respectively. This method has been successfully applied to wastewater samples collected in the Toronto area.

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