Interphase cytogenetics of bladder cancer progression: relationship between aneusomy, DNA ploidy pattern, histopathology, and clinical outcome

2000 ◽  
Vol 30 (1) ◽  
pp. 5-11 ◽  
Author(s):  
A. M. Cianciulli ◽  
R. Bovani ◽  
F. Leonardo ◽  
A. Antenucci ◽  
G. M. Gandolfo ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Clinical Outcome ◽  
Cancer Progression ◽  
Dna Ploidy ◽  
Dna Ploidy Pattern ◽  
Interphase Cytogenetics ◽  
Ploidy Pattern

Cytokinesis regulators as potential diagnostic and therapeutic biomarkers for human hepatocellular carcinoma

2021 ◽  
pp. 153537022110083
Author(s):  
Yiting Qiao ◽  
Yunxin Pei ◽  
Miao Luo ◽  
Muthukumar Rajasekaran ◽  
Kam M Hui ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
High Frequency ◽  
Genetic Instability ◽  
Dna Ploidy ◽  
Human Hepatocellular Carcinoma ◽  
Signaling Networks ◽  
Preclinical Studies ◽  
Dna Ploidy Pattern ◽  
Ploidy Pattern ◽  
Patient Prognosis

Cytokinesis, the final step of mitosis, is critical for maintaining the ploidy level of cells. Cytokinesis is a complex, highly regulated process and its failure can lead to genetic instability and apoptosis, contributing to the development of cancer. Human hepatocellular carcinoma is often accompanied by a high frequency of aneuploidy and the DNA ploidy pattern observed in human hepatocellular carcinoma results mostly from impairments in cytokinesis. Many key regulators of cytokinesis are abnormally expressed in human hepatocellular carcinoma, and their expression levels are often correlated with patient prognosis. Moreover, preclinical studies have demonstrated that the inhibition of key cytokinesis regulators can suppress the growth of human hepatocellular carcinoma. Here, we provide an overview of the current understanding of the signaling networks regulating cytokinesis, the key cytokinesis regulators involved in the initiation and development of human hepatocellular carcinoma, and their applications as potential diagnostic and therapeutic biomarkers.

DNA ploidy pattern and tumour spread in gastric cancer

1988 ◽  
Vol 75 (8) ◽  
pp. 770-773 ◽  
Author(s):  
X. de Aretxabala ◽  
Y. Yonemura ◽  
K. Sugiyama ◽  
T. Kamata ◽  
K. Konishi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Ploidy ◽  
Dna Ploidy Pattern ◽  
Tumour Spread ◽  
Ploidy Pattern

scholarly journals Two cases of anorectal malignant melanoma-with special reference to tumor nulcear DNA ploidy pattern.

1989 ◽  
Vol 42 (1) ◽  
pp. 118-122
Author(s):  
T. Nishimori ◽  
M. Okuno ◽  
M. Nagayama ◽  
T. Ikehara ◽  
K. Togo ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Special Reference ◽  
Dna Ploidy ◽  
Dna Ploidy Pattern ◽  
Anorectal Malignant Melanoma ◽  
Ploidy Pattern

scholarly journals p53 Expression in Colorectal Cancer:Relation to Tumor Type, DNA Ploidy Pattern, and Short-Term Survival

1996 ◽  
Vol 105 (5) ◽  
pp. 604-612 ◽  
Author(s):  
Giovanni Lanza ◽  
Iva Maestri ◽  
Alessandra Dubini ◽  
Roberta Gafa′ ◽  
Alessandra Santini ◽  
...  
Keyword(s):  
Dna Ploidy ◽  
Tumor Type ◽  
Short Term ◽  
Dna Ploidy Pattern ◽  
Term Survival ◽  
P53 Expression ◽  
Ploidy Pattern ◽  
Short Term Survival

scholarly journals Heterogeneity of DNA Ploidy Pattern in Carcinoma of the Gallbladder: Primary and Metastatic Sites

1997 ◽  
Vol 88 (9) ◽  
pp. 886-894 ◽  
Author(s):  
Noriaki Futakawa ◽  
Wataru Kimura ◽  
Hidehiko Ando ◽  
Tetsuichiro Muto ◽  
Yoshiyuki Esaki
Keyword(s):  
Dna Ploidy ◽  
Dna Ploidy Pattern ◽  
Carcinoma Of The Gallbladder ◽  
Ploidy Pattern ◽  
Metastatic Sites

DNA ploidy pattern of flat adenomas of the large bowel

1991 ◽  
Vol 34 (8) ◽  
pp. 696-698 ◽  
Author(s):  
T. Muto ◽  
T. Masaki ◽  
K. Suzuki
Keyword(s):  
Large Bowel ◽  
Dna Ploidy ◽  
Dna Ploidy Pattern ◽  
Ploidy Pattern ◽  
Flat Adenomas

Prognostic significance of DNA ploidy pattern in osteosarcomas in association with chemotherapy

1999 ◽  
Vol 137 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Katsuyuki Kusuzaki ◽  
Hideyuki Takeshita ◽  
Hiroaki Murata ◽  
Masazumi Hirata ◽  
Shin Hashiguchi ◽  
...  
Keyword(s):  
Dna Ploidy ◽  
Prognostic Significance ◽  
Dna Ploidy Pattern ◽  
Ploidy Pattern
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