Responses of the skin microcirculation to acetylcholine and to sodium nitroprusside in chronic uremic patients

2000 ◽  
Vol 30 (3) ◽  
pp. 157-162 ◽  
Author(s):  
A. Cupisti ◽  
M. Rossi ◽  
S. Placidi ◽  
R. Caprioli ◽  
E. Morelli ◽  
...  
Keyword(s):  
Sodium Nitroprusside ◽  
Skin Microcirculation ◽  
Uremic Patients

Human Skin Microcirculation after Brachial Plexus Block Evaluated by Wavelet Transform of the Laser Doppler Flowmetry Signal

2006 ◽  
Vol 105 (3) ◽  
pp. 478-484 ◽  
Author(s):  
Svein A. Landsverk ◽  
Per Kvandal ◽  
Trygve Kjelstrup ◽  
Uros Benko ◽  
Alan Bernjak ◽  
...  
Keyword(s):  
Wavelet Transform ◽  
Brachial Plexus ◽  
Sodium Nitroprusside ◽  
Laser Doppler Flowmetry ◽  
Brachial Plexus Block ◽  
Laser Doppler ◽  
Skin Microcirculation ◽  
Periodic Oscillations ◽  
Doppler Flowmetry ◽  
Plexus Block

Background The skin microcirculation may be evaluated noninvasively by laser Doppler flowmetry and iontophoresis with acetylcholine and sodium nitroprusside. Wavelet transform of the perfusion signal shows periodic oscillations of five characteristic frequencies in the interval 0.0095-1.6 Hz. The aim of the current study was to investigate alterations in skin microcirculation induced by brachial plexus block, with emphasis on the periodic oscillations. Methods Healthy nonsmokers undergoing hand surgery (n = 13) were anesthetized with brachial plexus block, using bupivacaine, lidocaine, and epinephrine. Skin microcirculation was evaluated by laser Doppler flowmetry and iontophoresis with acetylcholine and sodium nitroprusside before and after brachial plexus block. Wavelet transform of the perfusion signal was performed. As a control group, 10 healthy nonsmokers were included. Results In the anesthetized arm, skin perfusion after brachial plexus block increased from 19 (12-30) to 24 (14-39) arbitrary units (P < 0.01). A significant increase was also seen in the contralateral arm from 17 (14-32) to 20 (14-42) arbitrary units (P < 0.01). After brachial plexus block, spectral analysis revealed a significant reduction in relative amplitude of the oscillatory components within the 0.0095- to 0.021- (P < 0.001) and 0.021- to 0.052-Hz (P < 0.001) intervals in the anesthetized arm. Conclusion Alterations in skin microcirculation induced by brachial plexus block can be evaluated by wavelet transform of the laser Doppler flowmetry signal. Brachial plexus block reduces the oscillatory components within the 0.0095- to 0.021- and 0.021- to 0.052-Hz intervals of the perfusion signal. These alterations are related to inhibition of sympathetic activity and a possible impairment of endothelial function.

scholarly journals Responses of the skin microcirculation to acetylcholine and sodium nitroprusside in patients with NIDDM

Diabetologia ◽  
1995 ◽  
Vol 38 (11) ◽  
pp. 1337-1344 ◽  
Author(s):  
S. J. Morris ◽  
A. C. Shore ◽  
J. E. Tooke
Keyword(s):  
Sodium Nitroprusside ◽  
Skin Microcirculation

scholarly journals Responses of the skin microcirculation to acetylcholine and sodium nitroprusside in patients with NIDDM

Diabetologia ◽  
1995 ◽  
Vol 38 (11) ◽  
pp. 1337-1344 ◽  
Author(s):  
S. J. Morris ◽  
A. C. Shore ◽  
J. E. Tooke
Keyword(s):  
Sodium Nitroprusside ◽  
Skin Microcirculation

Penicillin-induced encephalopathy in uremic patients

JAMA ◽  
1967 ◽  
Vol 200 (2) ◽  
pp. 121-123 ◽  
Author(s):  
H. A. Bloomer
Keyword(s):  
Uremic Patients

Subunit Composition of Plasma von Willebrand Factor (vWF) in Two Uremic Patients with Acquired vWF Abnormalities

1992 ◽  
Vol 67 (01) ◽  
pp. 183-183 ◽  
Author(s):  
Giancarlo Castaman ◽  
Francesco Rodeghiero ◽  
Antonella Lattuada ◽  
Pier Mannuccio Mannucci ◽  
A Bianchi Bonomi
Keyword(s):  
Von Willebrand Factor ◽  
Subunit Composition ◽  
Uremic Patients ◽  
Von Willebrand ◽  
Willebrand Factor

An in vivo Model for the Assessment of Acute Fibrinolytic Capacity of the Endothelium

1997 ◽  
Vol 78 (04) ◽  
pp. 1242-1248 ◽  
Author(s):  
David E Newby ◽  
Robert A Wright ◽  
Christopher A Ludlam ◽  
Keith A A Fox ◽  
Nicholas A Boon ◽  
...  
Keyword(s):  
Blood Flow ◽  
Substance P ◽  
Sodium Nitroprusside ◽  
Plasma Concentrations ◽  
In Vivo Model ◽  
Forearm Circulation ◽  
Von Willebrand ◽  
Local Release ◽  
Willebrand Factor

SummaryThe effects on blood flow and plasma fibrinolytic and coagulation parameters of intraarterial substance P, an endothelium dependent vasodilator, and sodium nitroprusside, a control endothelium independent vasodilator, were studied in the human forearm circulation. At subsystemic locally active doses, both substance P (2-8 pmol/min) and sodium nitroprusside (2-8 μg/min) caused dose-dependent vasodilatation (p <0.001 for both) without affecting plasma concentrations of PAI-1, von Willebrand factor antigen or factor VIII:C activity. Substance P caused local increases in t-PA antigen and activity (p <0.001) in the infused arm while sodium nitroprusside did not. At higher doses, substance P increased blood flow and t-PA concentrations in the noninfused arm. We conclude that brief, locally active and subsystemic infusions of intraarterial substance P cause a rapid and substantial local release of t-PA which appear to act via a flow and nitric oxide independent mechanism. This model should provide a useful and selective method of assessing the in vivo capacity of the forearm endothelium to release t-PA acutely.

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