The Significance of Perineural Invasion as a Prognostic Factor in Patients with Gastric Carcinoma

Surgery Today ◽  
2003 ◽  
Vol 33 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Nüvit Duraker ◽  
Servet ŞiŞman ◽  
Günay Can
Keyword(s):  
Prognostic Factor ◽  
Gastric Carcinoma ◽  
Perineural Invasion

scholarly journals Meta-analysis – perineural invasion as prognostic factor in rectal cancer

2019 ◽  
Vol 39 (1) ◽  
pp. 74-80
Author(s):  
Jothi Rajasekaran Murugesan ◽  
Shenthil Prabhu Murugesan ◽  
Jim Yip ◽  
Kerry Hitos ◽  
Stephen Fulham ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Prognostic Factor ◽  
Perineural Invasion ◽  
Meta Analysis

Perineural invasion is a prognostic factor for biochemical failure after radical prostatectomy

2009 ◽  
Vol 16 (8) ◽  
pp. 682-686 ◽  
Author(s):  
Hwang Gyun Jeon ◽  
Jungbum Bae ◽  
Jun-Seok Yi ◽  
In Sik Hwang ◽  
Sang Eun Lee ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Radical Prostatectomy ◽  
Perineural Invasion ◽  
Biochemical Failure

The prognostic value of P53 in the nodal metastization of gastric cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14673-e14673
Author(s):  
Luisa Quaresma ◽  
Antonio CALDEIRA Fradique ◽  
Fernanda Cabrita ◽  
Alexandra Pupo ◽  
Guedes DA Silva ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Gastric Carcinoma ◽  
Lymph Node Metastases ◽  
P53 Protein ◽  
Mutant P53 ◽  
P53 Expression ◽  
Major Interest ◽  
Node Metastases

e14673 Background: Lymph node Metastases play a major role as an independent prognostic factor in gastric cancer. Presence of distal lymph node metastases assumes a pejorative prognostic significance, and represents a problem in terms of therapeutic approach. For this reason it’s of major interest to find predictive markers of distal lymph node chain involvement. The P53 tumor suppressor gene, a product of the TP53 gene works normally as a brake on DNA replication, as suppressor of angiogenesis and triggering of apoptosis. The gene most frequently mutated in gastric cancer is the TP53, that is responsible for the production of P53 mutant protein, which forms inactive complex with the native protein, and manifest by the overexpression of p53 in immunocytochemistry. The overexpression of P53 gene has been considered a bad prognostic factor associated mainly with lymph node metastases. Methods: This study seeks to determine the relation between the expression of P53 and the presence of distal lymph node metastases as an indicator for an extended lymphadenectomy. A total of 50 patients undergoing surgery with D2 lymphadenectomy for gastric carcinoma with curative intent were enrolled in this work. Therefore it was evaluated in 1,786 lymph nodes the correlation between the P53 expression with tumor location, size, histological type, depth , number of nodes involved, number of distal lymph node metastases and the TNM stage. Results: In all parameters, mutant P53 protein related with indicators of poor prognosis. In particular has demonstrated a statistical significant correlation (p=0.019) with the presence of distal lymph node metastases. The main objective of this study which was finding a prognostic predictor of distal nodal metastases has been reached. Conclusions: Mutant P53 protein is a good prognostic indicator, for the presence of distal lymph node involvement in gastric carcinoma.

scholarly journals Pattern of Perineural Invasion Is an Important Prognostic Factor for Oral Cavity Cancer

2016 ◽  
Vol 96 (2) ◽  
pp. S84-S85
Author(s):  
J.P. Harris ◽  
J.L. Shah ◽  
K.B. Schaberg ◽  
J.J. Chen ◽  
T.T. Bui ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Oral Cavity ◽  
Perineural Invasion ◽  
Oral Cavity Cancer ◽  
Important Prognostic Factor

Interaction Between Gastric Carcinoma Cells and Neural Cells Promotes Perineural Invasion by a Pathway Involving VCAM1

2015 ◽  
Vol 60 (11) ◽  
pp. 3283-3292 ◽  
Author(s):  
Qijun Xia ◽  
Qing-Ran Bai ◽  
Maosheng Dong ◽  
Xicai Sun ◽  
Haihong Zhang ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Perineural Invasion ◽  
Carcinoma Cells ◽  
Neural Cells
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