Changes in the expression of lipid-mediated signal-transducing enzymes in the rat Liver after partial hepatectomy

Surgery Today ◽  
2000 ◽  
Vol 30 (7) ◽  
pp. 622-630 ◽  
Author(s):  
Atsushi Watanabe ◽  
Shigeru Nakashima ◽  
Takahito Adachi ◽  
Shigetoyo Saji ◽  
Yoshinori Nozawa
Keyword(s):  
Partial Hepatectomy ◽  
Rat Liver

DEOXYCYTIDYLATE DEAMINASE LEVELS IN REGENERATING RAT LIVER

1961 ◽  
Vol 39 (6) ◽  
pp. 1043-1054 ◽  
Author(s):  
D. K. Myers ◽  
C. Anne Hemphill ◽  
Constance M. Townsend
Keyword(s):  
Dna Synthesis ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Deoxyribonucleic Acid ◽  
Regenerating Liver ◽  
Regenerating Rat Liver ◽  
High Level ◽  
Early Regeneration

Deoxycytidylate deaminase activity and net synthesis of deoxyribonucleic acid (DNA) in vivo were found to increase at approximately the same time during the early stages of liver regeneration. However, deaminase activity in the regenerating liver remained at a high level for 1 day after DNA synthesis had slowed down again during the later stages of regeneration. The increase in deaminase activity was restricted as a result of exposure to 600 r X radiation during early regeneration, but this effect only became evident 11–16 hours after the irradiation. Irradiation on the second day after partial hepatectomy, when deaminase levels in control regenerating livers were relatively constant, failed to affect the deaminase activity immediately but did produce a 40–50% decrease in activity 11–16 hours later. Other antimitotic agents, e.g., colchicine, had little effect on deaminase activity.

scholarly journals Changes of TGF-a, HGF, PCNA and IGFBP-1s mRNA after partial hepatectomy in rat liver

2003 ◽  
Vol 11 (4) ◽  
pp. 434-437 ◽  
Author(s):  
Ping Chen ◽  
Kun Li ◽  
Jia-Hong Dong ◽  
Ben-Li Han
Keyword(s):  
Partial Hepatectomy ◽  
Rat Liver

scholarly journals Changes of hepatocyte cell cycle after partial hepatectomy in cirrhotic rat liver

2003 ◽  
Vol 11 (8) ◽  
pp. 1152-1155
Author(s):  
Ping Chen ◽  
Kun Li ◽  
Jia-Hong Dong ◽  
Ben-Li Han
Keyword(s):  
Cell Cycle ◽  
Partial Hepatectomy ◽  
Rat Liver

scholarly journals Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy

2015 ◽  
Vol 61 (3) ◽  
pp. 381-383 ◽  
Author(s):  
I.V. Zverinsky ◽  
H.G. Zverinskaya ◽  
I.P. Sutsko ◽  
P.G. Telegin ◽  
A.G. Shlyahtun
Keyword(s):  
Cytochrome P450 ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Compensatory Growth ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Recovery Processes

We have studied the effect of berberine on the recovery processes of liver xenobiotic-metabolizing function during its compensatory growth after 70% partial hepatectomy. It was found the hepatic ability to metabolize foreign substances are not restored up to day 8. Administration of berberine (10 mg/kg intraperitoneally) for 6 days led to normalization of both cytochrome P450-dependent and flavin-containing monooxygenases. It is suggested that in the biotransformation of berberine involved not only cytochrome P450, but also flavin-containing monooxygenases.

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