Effect of Prostaglandin E1 on Ischemia–Reperfusion Injury During Abdominal Aortic Aneurysm Surgery

Surgery Today ◽  
2006 ◽  
Vol 36 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Hidenori Sako ◽  
Tetsuo Hadama ◽  
Shinji Miyamoto ◽  
Hirofumi Anai ◽  
Tomoyuki Wada ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Reperfusion Injury ◽  
Prostaglandin E1 ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Aneurysm Surgery ◽  
Abdominal Aortic ◽  
Aortic Aneurysm Surgery

Coronary Artery Revascularization Before Abdominal Aortic Aneurysm Surgery

1994 ◽  
Vol 79 (4) ◽  
pp. 661???669 ◽  
Author(s):  
Lee A. Fleisher ◽  
Eric D. Skolnick ◽  
Kenneth J. Holroyd ◽  
Harold P. Lehmann
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Coronary Artery ◽  
Aortic Aneurysm ◽  
Aneurysm Surgery ◽  
Coronary Artery Revascularization ◽  
Abdominal Aortic ◽  
Aortic Aneurysm Surgery

Exosome miR-23a-3p From Osteoblast Alleviates Spinal Cord Ischemia/Reperfusion Injury by Down-regulating KLF3-activated CCNL2 Transcription

2021 ◽  
Author(s):  
Cheng Wu ◽  
Qinghua Zhu ◽  
Yi Yao ◽  
Zhaoyang Shi ◽  
Chaojie Jin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Regulatory Mechanism ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia ◽  
Neurological Dysfunction ◽  
Aneurysm Surgery ◽  
Aortic Aneurysm Surgery ◽  
Geo Database

Background: Spinal cord ischemia/reperfusion injury (SCIRI) is usually caused by spinal surgery or aortic aneurysm surgery and can eventually lead to paralysis or paraplegia and neurological dysfunction. Exosomes are considered as one of the most promising therapeutic strategies for SCIRI as they can pass the blood-spinal barrier. Previous studies have proved that exosomes secreted by osteocytes have a certain slowing effect on SCIRI. Aim: We aimed to explore the effect of osteoblast secreted exosomes on SCIRI. Methods: Firstly, neurons and osteoblasts were co-cultured under different conditions. GEO database was utilized to detect the expression of miR-23a-3p in osteoblast exosomes. SCIRI cells were treated with exosomes, and the detection was taken to prove whether miR-23a-3p could slow the progression of SCIRI. Downstream gene and the potential regulatory mechanism were explored through database and functional experiments. Results: MiR-23a-3p was highly expressed in exosomes and it slowed down the process of SCIRI. Downstream mRNA KLF3 could bind to miR-23a-3p and was highly expressed in IRI. Moreover, CCNL2 was regulated by KLF3 and was highly expressed in IRI. Rescue experiments verified that miR-23a-3p suppressed the transcription of CCNL2 by targeting KLF3. Conclusion: Exosome miR-23a-3p from osteoblast alleviates SCIRI by down-regulating KLF3-activated CCNL2 transcription.

scholarly journals Adjusted Hospital Outcomes of Abdominal Aortic Aneurysm Surgery Reported in the Dutch Surgical Aneurysm Audit

2017 ◽  
Vol 65 (5) ◽  
pp. 1543
Author(s):  
N. Lijftogt ◽  
A.C. Vahl ◽  
E.D. Wilschut ◽  
B.H.P. Elsman ◽  
S. Amodio ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Aneurysm Surgery ◽  
Hospital Outcomes ◽  
Abdominal Aortic ◽  
Aortic Aneurysm Surgery
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