Effects of a 7-day infusion of glucose on insulin secretion in vivo and in vitro in ventromedial hypothalamic-lesioned obese rats

1998 ◽  
Vol 35 (1) ◽  
pp. 26-33 ◽  
Author(s):  
M. Kuboi ◽  
M. Egawa ◽  
N. Udaka ◽  
T. Ito ◽  
S. Inoue ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Insulin Secretion In Vivo ◽  
Obese Rats

Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo

2012 ◽  
Vol 302 (4) ◽  
pp. E403-E408 ◽  
Author(s):  
Mika Bando ◽  
Hiroshi Iwakura ◽  
Hiroyuki Ariyasu ◽  
Hiroshi Hosoda ◽  
Go Yamada ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Glucose Metabolism ◽  
Medium Chain Triglyceride ◽  
Physiological Role ◽  
Standard Diet ◽  
Entry Site ◽  
Insulin Secretion In Vivo

Whereas ghrelin is produced primarily in the stomach, a small amount of it is produced in pancreatic islets. Although exogenous administration of ghrelin suppresses insulin secretion in vitro or in vivo, the role of intraislet ghrelin in the regulation of insulin secretion in vivo remains unclear. To understand the physiological role of intraislet ghrelin in insulin secretion and glucose metabolism, we developed a transgenic (Tg) mouse model, rat insulin II promoter ghrelin-internal ribosomal entry site-ghrelin O-acyl transferase (RIP-GG) Tg mice, in which mouse ghrelin cDNA and ghrelin O-acyltransferase are overexpressed under the control of the rat insulin II promoter. Although pancreatic desacyl ghrelin levels were elevated in RIP-GG Tg mice, pancreatic ghrelin levels were not altered in animals on a standard diet. However, when Tg mice were fed a medium-chain triglyceride-rich diet (MCTD), pancreatic ghrelin levels were elevated to ∼16 times that seen in control animals. It seems likely that the gastric ghrelin cells possess specific machinery to provide the octanoyl acid necessary for ghrelin acylation but that this machinery is absent from pancreatic β-cells. Despite the overexpression of ghrelin, plasma ghrelin levels in the portal veins of RIP-GG Tg mice were unchanged from control levels. Glucose tolerance, insulin secretion, and islet architecture in RIP-GG Tg mice were not significantly different even when the mice were fed a MCTD. These results indicate that intraislet ghrelin does not play a major role in the regulation of insulin secretion in vivo.

scholarly journals 91 SALICYLATE INTOXICATION AND INSULIN SECRETION: “IN VIVO” AND “IN VITRO” STUDIES

1981 ◽  
Vol 15 (2) ◽  
pp. 198-198
Author(s):  
J C Basabe ◽  
L Bruno ◽  
E Alvarez ◽  
M E Fernández ◽  
E Astolfi
Keyword(s):  
Insulin Secretion ◽  
In Vitro Studies ◽  
Insulin Secretion In Vivo ◽  
Salicylate Intoxication

Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro

2012 ◽  
Vol 428 (4) ◽  
pp. 512-517 ◽  
Author(s):  
Abu Saleh Md. Moin ◽  
Hideki Yamaguchi ◽  
Marie Rhee ◽  
Ji-Wom Kim ◽  
Koji Toshinai ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Regulatory Peptide ◽  
Insulin Secretion In Vivo

scholarly journals Effects of vitamin A deficiency and repletion on rat insulin secretion in vivo and in vitro from isolated islets.

1987 ◽  
Vol 79 (1) ◽  
pp. 163-169 ◽  
Author(s):  
B S Chertow ◽  
W S Blaner ◽  
N G Baranetsky ◽  
W I Sivitz ◽  
M B Cordle ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Isolated Islets ◽  
Insulin Secretion In Vivo

Effect of Sucrose Diet on Insulin Secretion In Vivo and In Vitro and on Triglyceride Storage and Mobilisation of the Heart of Rats

1983 ◽  
Vol 15 (02) ◽  
pp. 69-76 ◽  
Author(s):  
Y. Lombardo ◽  
A. Chicco ◽  
N. Mocchiutti ◽  
M. de Rodi ◽  
B. Nusimovich ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Insulin Secretion In Vivo ◽  
Sucrose Diet
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