scholarly journals Clinical applications of bone graft substitutes in spine surgery: consideration of mineralized and demineralized preparations and growth factor supplementation

2001 ◽  
Vol 10 (0) ◽  
pp. S169-S177 ◽  
Author(s):  
Bobby Tay ◽  
Frank Kleinstueck ◽  
David Bradford ◽  
Sigurd Berven
Keyword(s):  
Growth Factor ◽  
Bone Graft ◽  
Spine Surgery ◽  
Clinical Applications ◽  
Bone Graft Substitutes

Bone graft substitutes for the promotion of spinal arthrodesis

2001 ◽  
Vol 10 (4) ◽  
pp. 1-5 ◽  
Author(s):  
Gregory A. Helm ◽  
Hayan Dayoub ◽  
John A. Jane
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Bone Graft ◽  
Bone Repair ◽  
Bone Growth ◽  
Transforming Growth Factor ◽  
Local Bone ◽  
Bone Graft Substitutes ◽  
Autologous Bone

In the prototypical method for inducing spinal fusion, autologous bone graft is harvested from the iliac crest or local bone removed during the spinal decompression. Although autologous bone remains the “gold standard” for stimulating bone repair and regeneration, modern molecular biology and bioengineering techniques have produced unique materials that have potent osteogenic activities. Recombinant human osteogenic growth factors, such as bone morphogenetic proteins, transforming growth factor–β, and platelet-derived growth factor are now produced in highly concentrated and pure forms and have been shown to be extremely potent bone-inducing agents when delivered in vivo in rats, dogs, primates, and humans. The delivery of pluripotent mesenchymal stem cells (MSCs) to regions requiring bone formation is also compelling, and it has been shown to be successful in inducing osteogenesis in numerous pre-clinical studies in rats and dogs. Finally, the identification of biological and nonbiological scaffolding materials is a crucial component of future bone graft substitutes, not only as a delivery vehicle for bone growth factors and MSCs but also as an osteoconductive matrix to stimulate bone deposition directly. In this paper, the currently available bone graft substitutes will be reviewed and the authors will discuss the novel therapeutic approaches that are currently being developed for use in the clinical setting.

Bone graft substitutes in spine surgery

2001 ◽  
Vol 12 (3) ◽  
pp. 216-222 ◽  
Author(s):  
Safdar N. Khan ◽  
Andrew Sama ◽  
Harvinder S. Sandhu
Keyword(s):  
Bone Graft ◽  
Spine Surgery ◽  
Bone Graft Substitutes

CLINICAL APPLICATIONS OF BONE GRAFT SUBSTITUTES

2000 ◽  
Vol 31 (3) ◽  
pp. 389-398 ◽  
Author(s):  
Safdar N. Khan ◽  
Emre Tomin ◽  
Joseph M. Lane
Keyword(s):  
Bone Graft ◽  
Clinical Applications ◽  
Bone Graft Substitutes

scholarly journals Improving the Clinical Evidence of Bone Graft Substitute Technology in Lumbar Spine Surgery

2012 ◽  
Vol 2 (4) ◽  
pp. 239-248 ◽  
Author(s):  
Wellington K. Hsu ◽  
M. S. Nickoli ◽  
J. C. Wang ◽  
J. R. Lieberman ◽  
H. S. An ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Bone Graft ◽  
Spine Surgery ◽  
Clinical Evidence ◽  
Bone Graft Substitute ◽  
Spine Fusion ◽  
Lumbar Spine Surgery ◽  
Lumbar Spine Fusion ◽  
Clinical Literature ◽  
Bone Graft Substitutes

Bone graft substitutes have been used routinely for spine fusion for decades, yet clinical evidence establishing comparative data remains sparse. With recent scrutiny paid to the outcomes, complications, and costs associated with osteobiologics, a need to improve available data guiding efficacious use exists. We review the currently available clinical literature, studying the outcomes of various biologics in posterolateral lumbar spine fusion, and establish the need for a multicenter, independent osteobiologics registry.

Chapter 10—Review of State of the Art: Growth Factor-Based Systems for Use as Bone Graft Substitutes

2009 ◽  
pp. 174-174-20
Author(s):  
CT Laurencin ◽  
M Attawia ◽  
R Rosier ◽  
EV Cheung ◽  
DS Katti ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Graft ◽  
State Of The Art ◽  
Bone Graft Substitutes

scholarly journals Individualized plasticity autograft mimic with efficient bioactivity inducing osteogenesis

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Yan Wei ◽  
Guixin Zhu ◽  
Zifan Zhao ◽  
Chengcheng Yin ◽  
Qin Zhao ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Graft ◽  
Secondary Trauma ◽  
Bone Grafts ◽  
Bone Scaffold ◽  
Fiber Network ◽  
Marrow Mesenchymal Stem Cells ◽  
Limited Application ◽  
Osteogenic Induction ◽  
Scaffold Materials

AbstractMineralized tissue regeneration is an important and challenging part of the field of tissue engineering and regeneration. At present, autograft harvest procedures may cause secondary trauma to patients, while bone scaffold materials lack osteogenic activity, resulting in a limited application. Loaded with osteogenic induction growth factor can improve the osteoinductive performance of bone graft, but the explosive release of growth factor may also cause side effects. In this study, we innovatively used platelet-rich fibrin (PRF)-modified bone scaffolds (Bio-Oss®) to replace autograft, and used cytokine (BMP-2) to enhance osteogenesis. Encouragingly, this mixture, which we named “Autograft Mimic (AGM)”, has multiple functions and advantages. (1) The fiber network provided by PRF binds the entire bone scaffold together, thereby shaping the bone grafts and maintaining the space of the defect area. (2) The sustained release of BMP-2 from bone graft promoted bone regeneration continuously. (3) AGM recruited bone marrow mesenchymal stem cells (BMSCs) and promote their proliferation, migration, and osteogenic differentiation. Thus, AGM developed in this study can improve osteogenesis, and provide new guidance for the development of clinical bone grafts.

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